YRC Public Data Repository - Protein Structure Prediction

Protein:	FRM2
Organism:	Saccharomyces cerevisiae
Length:	193 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRM2.

Description	E-value	Query Range	Subject Range
gi\|151943803 - gi\|151943803\|gb\|EDN62103.1\| conserved protein [Saccharomyces cerevisiae YJM789] FRM2_YEAST - Fatty acid repression mutant protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=F... FRM2 - Protein of unknown function, involved in the integration of lipid signaling pathways with cellular h...	9.0E-52	[1..193]	[1..193]
gi\|25335016 - pir\|\|C97307 nitroreductase family protein [imported] - Clostridium acetobutylicum gi\|15896557, gi\|... - gi\|15896557\|ref\|NP_349906.1\| nitroreductase family protein [Clostridium acetobutylicum ATCC 824], gi...	8.0E-51	[1..186]	[1..190]
gi\|161337373, gi... - gi\|161620562\|ref\|YP_001594448.1\| hypothetical protein BCAN_B0498 [Brucella canis ATCC 23365], gi\|161... gi\|163844659, gi... - gi\|163844659\|ref\|YP_001622314.1\| hypothetical protein BSUIS_B0496 [Brucella suis ATCC 23445], gi\|163... gi\|189021463, gi... - gi\|189022889\|ref\|YP_001932630.1\| hypothetical protein BAbS19_II06890 [Brucella abortus S19], gi\|1890... gi\|225686295, gi... - gi\|225686295\|ref\|YP_002734267.1\| hypothetical protein BMEA_B0473 [Brucella melitensis ATCC 23457], g... gi\|254691134 - gi\|254691134\|ref\|ZP_05154388.1\| hypothetical protein Babob68_13478 [Brucella abortus bv. 6 str. 870] gi\|17989117, gi\|... - gi\|17989117\|ref\|NP_541750.1\| putative cytoplasmic protein [Brucella melitensis 16M], gi\|17984965\|gb\|... gi\|254699748 - gi\|254699748\|ref\|ZP_05161576.1\| hypothetical protein Bsuib55_02636 [Brucella suis bv. 5 str. 513] gi\|25335024 - pir\|\|AC3606 hypothetical cytosolic protein BMEII0772 [imported] - Brucella melitensis (strain 16M) gi\|254705996 - gi\|254705996\|ref\|ZP_05167824.1\| hypothetical protein BpinM_03073 [Brucella pinnipedialis M163/99/10] gi\|254695560 - gi\|254695560\|ref\|ZP_05157388.1\| hypothetical protein Babob3T_13162 [Brucella abortus bv. 3 str. Tuly... gi\|23500244, gi\|... - gi\|23500244\|ref\|NP_699684.1\| hypothetical protein BRA0497 [Brucella suis 1330], gi\|23463849\|gb\|AAN33... gi\|254698918 - gi\|254698918\|ref\|ZP_05160746.1\| hypothetical protein Babob28_14784 [Brucella abortus bv. 2 str. 86/8... gi\|254715390 - gi\|254715390\|ref\|ZP_05177201.1\| hypothetical protein BcetM_02874 [Brucella ceti M13/05/1] gi\|254732365 - gi\|254732365\|ref\|ZP_05190943.1\| hypothetical protein Babob42_14574 [Brucella abortus bv. 4 str. 292] gi\|254711704 - gi\|254711704\|ref\|ZP_05173515.1\| hypothetical protein BpinB_15929 [Brucella pinnipedialis B2/94] gi\|254712319 - gi\|254712319\|ref\|ZP_05174130.1\| hypothetical protein BcetM6_02859 [Brucella ceti M644/93/1] gi\|83269621 - gi\|83269621\|ref\|YP_418912.1\| hypothetical protein BAB2_0740 [Brucella melitensis biovar Abortus 2308... gi\|62197832, gi\|... - gi\|62317639\|ref\|YP_223492.1\| hypothetical protein BruAb2_0725 [Brucella abortus bv. 1 str. 9-941], g... gi\|82939895 - gi\|82939895\|emb\|CAJ12906.1\| conserved hypothetical protein [Brucella melitensis biovar Abortus 2308]	8.0E-47	[3..187]	[1..191]
gi\|254235561, gi... - gi\|84320543\|ref\|ZP_00968916.1\| COG3560: Predicted oxidoreductase related to nitroreductase [Pseudomo... gi\|107102023 - gi\|107102023\|ref\|ZP_01365941.1\| hypothetical protein PaerPA_01003071 [Pseudomonas aeruginosa PACS2] gi\|254241007, gi... - gi\|84326902\|ref\|ZP_00974926.1\| COG3560: Predicted oxidoreductase related to nitroreductase [Pseudomo... gi\|11349608 - pir\|\|A83323 hypothetical protein PA2575 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|9948637, gi\|1... - gi\|9948637\|gb\|AAG05963.1\|AE004686_1 hypothetical protein PA2575 [Pseudomonas aeruginosa PAO1], gi\|15... gi\|218891446, gi... - gi\|218891446\|ref\|YP_002440313.1\| putative nitroreductase [Pseudomonas aeruginosa LESB58], gi\|2187716...	2.0E-46	[3..187]	[1..191]
gi\|85103226 - gi\|85103226\|ref\|XP_961472.1\| hypothetical protein NCU03696 [Neurospora crassa OR74A] gi\|28923018, gi\|... - gi\|32404770\|ref\|XP_322998.1\| hypothetical protein ( (AL451014) conserved hypothetical protein [Neuro...	2.0E-45	[1..184]	[1..195]
gi\|15673895, gi\|... - gi\|15673895\|ref\|NP_268070.1\| hypothetical protein L174788 [Lactococcus lactis subsp. lactis Il1403],... gi\|25335011 - pir\|\|A86864 conserved hypothetical protein ytjD [imported] - Lactococcus lactis subsp. lactis (strai...	9.0E-45	[7..187]	[3..194]
gi\|25521688 - pir\|\|AB3185 conserved hypothetical protein Atu5207 [imported] - Agrobacterium tumefaciens (strain C5... gi\|15161965, gi\|... - gi\|17938792\|ref\|NP_535580.1\| hypothetical protein Atu5207 [Agrobacterium tumefaciens str. C58], gi\|1...	2.0E-43	[7..187]	[82..268]
gi\|148268486, gi... - gi\|90586915\|ref\|ZP_01242600.1\| Nitroreductase [Staphylococcus aureus subsp. aureus JH9], gi\|90429492... gi\|15927608, gi\|... - gi\|15927608\|ref\|NP_375141.1\| hypothetical protein SA1840 [Staphylococcus aureus subsp. aureus N315],... gi\|156722484, gi... - gi\|156980349\|ref\|YP_001442608.1\| hypothetical protein SAHV_2018 [Staphylococcus aureus subsp. aureus... gi\|25335018 - pir\|\|G89994 conserved hypothetical protein SA1840 [imported] - Staphylococcus aureus (strain N315) gi\|15925023, gi\|... - gi\|15925023\|ref\|NP_372557.1\| hypothetical protein SAV2033 [Staphylococcus aureus subsp. aureus Mu50]... gi\|150394549, gi... - gi\|90584497\|ref\|ZP_01240221.1\| Nitroreductase [Staphylococcus aureus subsp. aureus JH1], gi\|90426448... gi\|253315015 - gi\|253315015\|ref\|ZP_04838228.1\| hypothetical protein SauraC_02342 [Staphylococcus aureus subsp. aure... gi\|255006822 - gi\|255006822\|ref\|ZP_05145423.2\| hypothetical protein SauraM_10150 [Staphylococcus aureus subsp. aure...	1.0E-42	[6..184]	[12..197]

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Predicted Domain #1

Region A:
Residues: [1-193]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPTGNYLNA ITNRRTIYNL KPELPQGVGL DDVKRTVHVI LKNTPTAFNS QVNRAVIIVG  60
   61 DTHKRIWDAV ASAMPTAEAK KRPESCRDEA YGSVIFFTDE GPTEKLQRDF PALAAAFPTC 120
  121 AAHTTGAVQI QSWTALELLG LGANLQHYND YVKSALPQDV PIAWTVQSQL VFGVPTALPE 180
  181 EKTFINNVIN VYH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.69897
Match:	1bkjA_
Description:	Flavin reductase P (NADPH:FMN oxidoreductase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.88351700678	bayes_pls_golite062009
NAD(P)H nitroreductase activity	1.73743442947569	bayes_pls_golite062009
catalytic activity	1.11149969304282	bayes_pls_golite062009
protein binding	0.385179389448981	bayes_pls_golite062009
oxidoreductase activity	0.27929339949687	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: