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Protein Overview: STP22

General Information:
Name(s) found: STP22 / YCL008C [SGD]
Description(s) found:
Found 7 descriptions.
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  • Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 296 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article][IPILink to PubMed article]
    ESCRT I complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ICLink to PubMed article]
    telomere maintenance [IMPLink to PubMed articleLink to PubMed article]
    protein targeting to membrane [IMPLink to PubMed article][IPILink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANGKISVP EAVVNWLFKV IQPIYNDGRT TFHDSLALLD NFHSLRPRTR VFTHSDGTPQ  60
   61 LLLSIYGTIS TGEDGSSPHS IPVIMWVPSM YPVKPPFISI NLENFDMNTI SSSLPIQEYI 120
  121 DSNGWIALPI LHCWDPAAMN LIMVVQELMS LLHEPPQDQA PSLPPKPNTQ LQQEQNTPPL 180
  181 PPKPKSPHLK PPLPPPPPPQ PASNALDLMD MDNTDISPTN HHEMLQNLQT VVNELYREDV 240
  241 DYVADKILTR QTVMQESIAR FHEIIAIDKN HLRAVEQAIE QTMHSLNAQI DVLNRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..205] PSI-BLAST 114.9794 Tumor susceptibility gene 101 (TSG101) UEV domain
    2 View Details [206..296] MSA 1.057981 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle