YRC Public Data Repository - Protein Structure Prediction

Protein:	STP22
Organism:	Saccharomyces cerevisiae
Length:	296 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STP22.

Description	E-value	Query Range	Subject Range
STP22 - Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into ... gi\|190406431 - gi\|190406431\|gb\|EDV09698.1\| hypothetical protein SCRG_05394 [Saccharomyces cerevisiae RM11-1a] gi\|207347351 - gi\|207347351\|gb\|EDZ73550.1\| YCL008Cp-like protein [Saccharomyces cerevisiae AWRI1631] STP22_YEAST - Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease OS=Sac...	1.0E-80	[1..293]	[1..293]
TSG101-PA - The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, F...	9.0E-69	[12..295]	[3..279]
gi\|1870128 - gi\|1870128\|emb\|CAB06793.1\| unknown [Saccharomyces pastorianus]	3.0E-68	[1..293]	[1..286]
gi\|114636476 - gi\|114636476\|ref\|XP_001173373.1\| PREDICTED: tumor susceptibility gene 101 isoform 1 [Pan troglodytes... TSG101 - tumor susceptibility gene 101 gi\|60813968, gi\|... - gi\|61355217\|gb\|AAX41115.1\| tumor susceptibility gene 101 [synthetic construct], gi\|60813968\|gb\|AAX36...	3.0E-67	[12..288]	[2..255]
TS101_MOUSE - Tumor susceptibility gene 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2	4.0E-66	[12..288]	[2..256]
gi\|9454364 - gi\|9454364\|gb\|AAF87776.1\| tumor susceptibility protein 101 [Chelonia mydas]	4.0E-66	[12..288]	[2..257]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-41	[67..251]	[1481..1669]
ELC_ARATH - Protein ELC OS=Arabidopsis thaliana GN=ELC PE=1 SV=1	4.0E-38	[1..207]	[19..203]

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Predicted Domain #1

Region A:
Residues: [1-205]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANGKISVP EAVVNWLFKV IQPIYNDGRT TFHDSLALLD NFHSLRPRTR VFTHSDGTPQ  60
   61 LLLSIYGTIS TGEDGSSPHS IPVIMWVPSM YPVKPPFISI NLENFDMNTI SSSLPIQEYI 120
  121 DSNGWIALPI LHCWDPAAMN LIMVVQELMS LLHEPPQDQA PSLPPKPNTQ LQQEQNTPPL 180
  181 PPKPKSPHLK PPLPPPPPPQ PASNA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	114.9794
Match:	1kppA_
Description:	Tumor susceptibility gene 101 (TSG101) UEV domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [206-296]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLMDMDNTD ISPTNHHEML QNLQTVVNEL YREDVDYVAD KILTRQTVMQ ESIARFHEII  60
   61 AIDKNHLRAV EQAIEQTMHS LNAQIDVLNR K

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.955	0.045	protein targeting to vacuole	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits