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Protein Overview: HIS7

General Information:
Name(s) found: HIS7 / YBR248C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 552 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: purine nucleoside monophosphate biosynthetic process [TASLink to PubMed article]
    histidine biosynthetic process [TASLink to PubMed article]
    Molecular Function: imidazoleglycerol-phosphate synthase activity [IDALink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVVHVIDVE SGNLQSLTNA IEHLGYEVQL VKSPKDFNIS GTSRLILPGV GNYGHFVDNL  60
   61 FNRGFEKPIR EYIESGKPIM GICVGLQALF AGSVESPKST GLNYIDFKLS RFDDSEKPVP 120
  121 EIGWNSCIPS ENLFFGLDPY KRYYFVHSFA AILNSEKKKN LENDGWKIAK AKYGSEEFIA 180
  181 AVNKNNIFAT QFHPEKSGKA GLNVIENFLK QQSPPIPNYS AEEKELLMND YSNYGLTRRI 240
  241 IACLDVRTND QGDLVVTKGD QYDVREKSDG KGVRNLGKPV QLAQKYYQQG ADEVTFLNIT 300
  301 SFRDCPLKDT PMLEVLKQAA KTVFVPLTVG GGIKDIVDVD GTKIPALEVA SLYFRSGADK 360
  361 VSIGTDAVYA AEKYYELGNR GDGTSPIETI SKAYGAQAVV ISVDPKRVYV NSQADTKNKV 420
  421 FETEYPGPNG EKYCWYQCTI KGGRESRDLG VWELTRACEA LGAGEILLNC IDKDGSNSGY 480
  481 DLELIEHVKD AVKIPVIASS GAGVPEHFEE AFLKTRADAC LGAGMFHRGE FTVNDVKEYL 540
  541 LEHGLKVRMD EE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DUS3 HIS7 YIR035C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HIS7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] PSI-BLAST 10161.0 Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF; GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF
    2 View Details [238..552] PSI-BLAST 10161.0 Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF; GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • imidazoleglycerol-phosphate synthase activity
    		•  8.34101262147614 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.59881271808929 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  2.2869987398931 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine synthase activity
    		•  1.78446504815207 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.7339517212315 bayes_pls_golite062009
  • ligase activity
    		•  1.70348758031146 bayes_pls_golite062009
  • isomerase activity
    		•  1.51213365216354 bayes_pls_golite062009
  • catalytic activity
    		•  1.30391542469987 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  1.28138987648581 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  1.25854815869201 bayes_pls_golite062009
  • binding
    		•  1.22860407524238 bayes_pls_golite062009
  • ribulose-phosphate 3-epimerase activity
    		•  0.982517927791965 bayes_pls_golite062009
  • orotidine-5'-phosphate decarboxylase activity
    		•  0.758594564254247 bayes_pls_golite062009
  • indole-3-glycerol-phosphate synthase activity
    		•  0.549444136526559 bayes_pls_golite062009
  • transferase activity
    		•  0.540671801549001 bayes_pls_golite062009
  • tryptophan synthase activity
    		•  0.426391242491024 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0592570704569402 bayes_pls_golite062009
  • kinase activity
    		•  0.0299457182627273 bayes_pls_golite062009
  • protein binding
    		•  0.0152024556625711 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle