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Protein Overview: KTR4

General Information:
Name(s) found: KTR4 / YBR199W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 464 amino acids

    Gene Ontology:
    Cellular Component: Golgi apparatus [ISSLink to PubMed article]
    Biological Process: protein amino acid N-linked glycosylation [ISSLink to PubMed article]
    Molecular Function: mannosyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLSKRILK PVLSVIILIS IAVTVVLYFL TANENYLQAV KDSAKSQYAS LRESYKSITG  60
   61 KTESADELPD HDAEVLDSIM DRLHEPLYEK DTFDPNEVLA ENKQLYEEFL LQEISEPKVD 120
  121 NLVRSGDPLA GKAKGTILSL VRNSDLEDII SSIQQLEEEY NKNFGYPYTF LNDEEFTDEF 180
  181 KDGIKSILPK DRVVEFGTIG PDNWNMPDSI DRERYDQEMD KMSKENIQYA EVESYHNMCR 240
  241 FYSKEFYHHP LLSKYKYVWR LEPNVNFYCK INYDVFQFMN KNDKIYGFVL NLYDSPQTIE 300
  301 TLWTSTMDFV EEHPNYLNVN GAFAWLKDNS QNPKNYDYTQ GYSTCHFWTN FEIVDLDFLR 360
  361 SEPYEKYMQY LEEKGGFYYE RWGDAPVRSL ALALFADKSS IHWFRDIGYH HTPYTNCPTC 420
  421 PADSDRCNGN CVPGKFTPWS DLDNQNCQAT WIRHSMSEEE LEMY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GNT1 KRE2 KTR4 MNN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data KTR4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..464] Pfam 222.142668 Glycolipid 2-alpha-mannosyltransferase Confident ab initio structure predictions are available.
    2 View Details [116..464] PSI-BLAST 148.0 Crystal structure of yeast alpha1,2-mannosyltransferase Kre2p/Mnt1p

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mannosyltransferase activity
    		•  5.57855076532185 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  4.49413422196176 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  4.08451171179562 bayes_pls_golite062009
  • alpha-1,2-mannosyltransferase activity
    		•  3.80392076707564 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  3.4614674054855 bayes_pls_golite062009
  • transferase activity
    		•  3.32517438937547 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  3.19923094610567 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.60650378115696 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.51696952719873 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.86990263440735 bayes_pls_golite062009
  • uridylyltransferase activity
    		•  1.27888067902271 bayes_pls_golite062009
  • binding
    		•  0.948692623641759 bayes_pls_golite062009
  • glucuronosyltransferase activity
    		•  0.36353543999278 bayes_pls_golite062009
  • protein binding
    		•  0.124656890356575 bayes_pls_golite062009
  • UDP-galactosyltransferase activity
    		•  0.10185872015123 bayes_pls_golite062009
  • galactosyltransferase activity
    		•  0.0931461042017721 bayes_pls_golite062009
  • alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
    		•  0.0339369954475406 bayes_pls_golite062009
  • acetylglucosaminyltransferase activity
    		•  0.0278258721775009 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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