Protein Overview: UACA_MOUSE

General Information:
Name(s) found:	UACA_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|91207951\|sp\|Q8CGB3.2\|UACA_MOUSE RecName: Full=Uveal autoantigen with coiled-coil domains and ankyrin repeats; AltName: Full=Nuclear membrane-binding protein; Short=Nucling [NCBI NR] Uveal autoantigen with coiled-coil domains and ankyrin repeats OS=Mus musculus GN=Uaca PE=1 SV=2 [Swiss-Prot] Tax_Id=10090 Splice Isoform 1 of Uveal autoantigen with coiled-coil domains and ankyrin repeats protein [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] Uveal autoantigen with coiled-coil domains and ankyrin repeats (Nuclear membrane-binding protein) (Nucling) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Uaca Isoform 1 of Uveal autoantigen with coiled-coil domains and ankyrin repeats [mouse-ipi-250309-contam.fasta] Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein) [nr-271106-contam.fasta] IPI:IPI00742359.1\|SWISS-PROT:Q8CGB3-1 Tax_Id=10090 Gene_Symbol=Uaca Isoform 1 of Uveal autoantigen with coiled-coil domains and ankyrin repeats [ipi.MOUSE.fasta.20090209] Isoform 1 of Uveal autoantigen with coiled-coil domains and ankyrin repeats OS=Mus musculus GN=Uaca [011711_HMR.fasta] sp\|Q8CGB3\|UACA_MOUSE Uveal autoantigen with coiled-coil domains and ankyrin repeats OS=Mus musculus GN=Uaca PE=1 SV=2 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1411 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] nuclear envelope [IDA] nucleus [IDA] apoptosome [IDA] cytoskeleton [IEA] soluble fraction [IDA] perinuclear region of cytoplasm [IDA] cytoplasm [IDA] cytosol [IDA]
Biological Process:	positive regulation of caspase activity [IDA][IMP] positive regulation of protein import into nucleus [IMP] negative regulation of inflammatory response [IMP] positive regulation of apoptosis [IDA][IMP] induction of apoptosis by oxidative stress [IMP] response to UV [IMP] DNA damage response, signal transduction resulting in induction of apoptosis [IMP] negative regulation of NF-kappaB import into nucleus [IMP]
Molecular Function:	protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSLKSRLWK QDAPGPTSPS SPTAVASTQS AEWNKYDDRL MKAAERGDVE KVSSILAKKG  60
   61 VHPGKLDVEG RSAFHVVASK GNLECLNAIL THGIDVATRD SAGRNALHLA AKYGHALCLQ 120
  121 KLLQYNCPTE HVDLQGRTAL HDAVMADCPS SIQLLCDHGA SVNAKDIDGR TPLVLATQMC 180
  181 RPTICQLLID RGADVNSRDK QNRTALMLGC EYGCRDAVEV LVKNGADLTL LDALGHDSSY 240
  241 YARIGDNLDI LNLLKTASEN TNKGRELWRK GPPLQQRNLS HTQDEGSVKS TQREQREPHS 300
  301 FQDLEIENED LREKLRKIQQ EQRILLDKVN GLQLQLNEEV MVADDLESER EKPKSLLAAK 360
  361 EKQHEESLRT IEALKNRFKY FESDHPGPGS YPSNRKEDML HKQGQMYTTE PQCASPGIPP 420
  421 HMHSRSMLRP LELSLPSQTS YSENEILKKE LETLRTYYDS AKQDRLKFQN ELAHKVAECK 480
  481 ALALECERVK EDSDEQIKQL EDALKDVQKR MYESEGKVKQ MQTHFLALKE HLTNEAATGS 540
  541 HRIIEELREQ LKDLKGKYEG ASAEVGKLRS QIKQSEMLVG EFKRDEGRLV EENKRLQKEC 600
  601 GTCEVELERR GRRVVELEGQ LKELGAKLAL SVPTEKFESM KSSLSNDINE KVKRLAEVGR 660
  661 DYESAQGEIR QLKRDLESVR AQHIRPEEHE QLRSRLEQKS GELGKKVSEL TLKNQTLQKD 720
  721 VEKLHADNKL LNQQVHSLTV EMKTRYVPLR VSEEMKRSHD VNVEDLNKKL SEATQRYAEK 780
  781 KQEAERLLAE NDKLTKNVSR LEAVFVAPEK HEKELMGLKS NIAELKKQLS ELNKKCGEGQ 840
  841 EKIRALMSEN SSLKKTLSSQ YVPAKTHEEV KASLNSTVEK TNRALLEAKK RFDDTSQEVS 900
  901 KLRDENEVLR RNLENVQNQM KADYVSLEEH SRRMSTVSQS LKEAQEANAA ILADHRQGQE 960
  961 EIVSLHAEIK AQKKELDTIQ ECIKLKYAPL ARLEECERKF KATEKGLKEQ LSEQTHKCRQ1020
 1021 RDEEVKKGKQ ENERLRADLA ALQKELQDRN ALAEEAREAE RALSGKADEL SKQLKDLSQK1080
 1081 YSDVKSEREK LVEEKAKQAS EILAAQNLLQ KQPVPLEQVE ALKKSLNGTI EQLKEELRSK1140
 1141 QRCLEREQQT VSQLQQLLEN QKNSSVTLAE HLKLKEALEK EVGIMKASLR EKEEESQKKT1200
 1201 KEVSKLQTEV QTTKQALKNL ETREVVDMSK YKATKNDLET QISNLNDKLA SLNRKYDQAC1260
 1261 EEKVSAKDEK ELLHLSIEQE IRDQKERCDK SLTTIMELQQ RIQESAKQIE AKDNKITELL1320
 1321 NDVERLKQAL NGLSQLTYSS GSPTKRQSQL VDTLQQRVRD LQQQLADADR QHQEVIAIYR1380
 1381 THLLSAAQGH MDEDVQAALL QIIQMRQGLV C

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.57

Protein Overview: UACA_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: