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Protein Overview: NAT1-PC

General Information:
Name(s) found: NAT1-PC / FBpp0100139 [FlyBase]
Description(s) found:
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  • gi|85725014|ref|NP_001033943.1| NAT1, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|84795757|gb|ABC66062.1| NAT1, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|57157225|dbj|BAD83642.1| hypothetical protein [Drosophila melanogaster] [NCBI NR]
  • The gene NAT1 is referred to in FlyBase by the symbol Dmel\NAT1 (CG3845, FBgn0010488). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8803502..8810745. It has the cytological map location 49E1. Based on sequence similarity, it is predicted to have molecular function</span>: translation initiation factor activity. There is experimental evidence that it is involved in the biological process</span>: autophagic cell death; salivary gland cell autophagic cell death. 8 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • type=protein; loc=2R:join(8805789..8808364,8808490..8810315,8810384..8810562); ID=FBpp0100139; name=NAT1-PC; parent=FBgn0010488,FBtr0100672; dbxref=FlyBase_Annotation_IDs:CG3845-PC,FlyBase:FBpp0100139,GB_protein:ABC66062.1,REFSEQ:NP_001033943,GB_protein:A [fly-100309-contam.fasta]
  • CG3845-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • hypothetical protein [Drosophila melanogaster] [nr-271106-contam.fasta]
  • lethal (2) 01424 CG3845-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(8805789..8808364,8808490..8810315,8810384..8810562); ID=FBpp0100139; name=NAT1-PC; parent=FBgn0010488,FBtr0100672; dbxref=FlyBase_Annotation_IDs:CG3845-PC,FlyBase:FBpp0100139,GB_protein:ABC66062.1,REFSEQ:NP_001033943,GB_protein:ABC66062; MD5=4f62a79ab0edecbb786995262666ece4; length=1526; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(8805789..8808364,8808490..8810315,8810384..8810562); ID=FBpp0100139; name=NAT1-PC; parent=FBgn0010488,FBtr0100672; dbxref=FlyBase_Annotation_IDs:CG3845-PC,FlyBase:FBpp0100139,GB_protein:ABC66062.1,REFSEQ:NP_001033943,GB_protein:ABC66062; MD5=4f62a79ab0edecbb786995262666ece4; length=1526; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • NAT1, isoform C (Fragment) OS=Drosophila melanogaster GN=NAT1 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(8805789..8808364,8808490..8810315,8810384..8810562); ID=FBpp0100139; name=NAT1-PC; parent=FBgn0010488,FBtr0100672; dbxref=FlyBase_Annotation_IDs:CG3845-PC,FlyBase:FBpp0100139,GB_protein:ABC66062.1,REFSEQ:NP_001033943,GB_protein:ABC66062,FlyMine:FBpp0100139,modMine:FBpp0100139; MD5=4f62a79ab0edecbb786995262666ece4; length=1526; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • NAT1, isoform C (Fragment) OS=Drosophila melanogaster GN=NAT1 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 1526 amino acids

    Gene Ontology:
    Cellular Component: mRNA cap binding complex [ISS]
    Biological Process: RNA metabolic process [IEA]
    autophagic cell death [IEP]
    salivary gland cell autophagic cell death [IEP]
    Molecular Function: translation initiation factor activity [ISS]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPDPQKTGKP TKTPRVAHSV PPKHAPISPP SRSRKASTIP LSTYDAAPLL HSYDDSPQRW  60
   61 SGVTNGHQAG VIIDQFRGGK AIIIEGGTST GDTKSIGGGS DLRLVITANP SEIERNYEQP 120
  121 TNRGGGGGGG VIGVSCGGQT PPTPSVGKTL LNTSPNLLPI TTATDTFNNL KNLVKIDKGS 180
  181 SPSSGSNSLG GNYRKGGSNG SGYKSAGGNG GSPAISGNSE GGRNGSRSSG GPTGHFSTGY 240
  241 SKNSVKIRQH DSEVSPRPRR SYQGDSSSSR YYPKNSDILG QGLGGNSDSY NGSSSSGRYQ 300
  301 QQDQQGGSHR GSRSNYHSNS DGSYNRSINS NSVGGGGSGA VGSGSGGSNY RSARNYENGN 360
  361 GSNGTQPRYG SGNGNGNSSN SNSSSGYNGS AASSTNSKSS YGASRGGNDG GVSSGYSSNY 420
  421 RDNYEDSPSH QRYNNTNSLE RNGGGGSGAG ASGGPRSYGR SDADRYGGTP SSRTPNLRNG 480
  481 SASAQISGST SNSSNISLNS GSASAAGGGT PHSQQQQERS QAGKASTPPP ITGRWIPPSL 540
  541 RPQHGLTQSE KNDAVFRRVR GILNKLTPEK FQELSDELLK LDLNSIAILK GVILLIFDKA 600
  601 LDEPKYSSMY AQLCKRLSEE APSFDKEPSN SSTFLRLLIA VCRDKFNNRL KRDENDNRPP 660
  661 PENEADEEER RHLAKQRMLG NVKFIGELNK LDMLSKNVLH QCIMELFDKK KKRTAGTQEM 720
  721 CEDMECLAQL LKTCGKNLDS EQGKELMNQY FEKLERRSKS SEYPPRIRFM LKDVIELRQN 780
  781 NWVPRKLGTT EGPVPIKQIR SDDDSIIRTP FPNRNRDMRN NDRDSDSWMN RFHLNIQPGG 840
  841 YNDMFSGLSV TGASPIVSPF ATSNRDRDRD NRQYNNRGDR NRDRDQGGSG GANYGNRYNK 900
  901 HNQNGGGSGG GSSNNRDRDD SRRNNDRDRD RNDGQYGGNQ LLGSKELAPR FKRNLITTNQ 960
  961 DAVENLQMRP AANSLLFRAA SQNQKFPATL PMSTPPNSSG SNNQGSSQGQ LSNSHYPMLG1020
 1021 TPTSHLINPT RPSSTPSAEY ADNRTLLGVQ QERGLKATSS SPNFSSGAEK LDLDGQAGRK1080
 1081 GSHDGKDQGK NGSVERPSTP AGGIGSAKQQ KKDKGPNKEE LSKKASQYFK DRFYYDEEED1140
 1141 AEVTEIEIKD IDETKTEEAD AAPVEVSEVK EDAAIPVTTP DRFTKLVDGF LELKLPEKAL1200
 1201 KDVCINLLME VLDRVNDVFL ERAVRLLQTL RKQSNIKPNI VVEIFKQVVN KMNEREALNP1260
 1261 RIVSLVASLL AKTICEPALL KLSDIANFTD NGQHYPLFLL VLQQLVKVIG KDALEEKFRA1320
 1321 SKVDLMNSLP EADRNKERLA GILEDRKLSF LYPLLKVQAE MLKQLQSDPN PNNFYKWIKA1380
 1381 NVDNKYYKDP GFIQALMTVV VKYVTKETTL ADNLDPKEHP EKSVTQKEQQ LLENYSQMLQ1440
 1441 TFLGQNELQL MALYALQTFC YNENFPKGML CRWFKYLYES EIIEEEAFVL WKEEISDKYP1500
 1501 GKGSALFQVN AWLTWLQEAE SEDDED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..548] PSI-BLAST 23.39794 No description for 1y0fA was found.
    2 View Details [549..882] PSI-BLAST 102.0 Eukaryotic initiation factor eIF4G
    3 View Details [883..969] deduced N/A No confident structure predictions are available.
    4 View Details [970..1163] deduced N/A No confident structure predictions are available.
    5 View Details [1164..1526] PSI-BLAST 124.0 C-terminal portion of human eIF4GI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • RNA cap binding
    		•  3.2160251815809 bayes_pls_golite062009
  • binding
    		•  1.99013774955562 bayes_pls_golite062009
  • protein binding
    		•  1.75981610748679 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle