Protein Overview: unc-13-PC

General Information:
Name(s) found:	unc-13-PC / FBpp0088306 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|62484411\|ref\|NP_726614.2\| unc-13, isoform C [Drosophila melanogaster] [NCBI NR] gi\|61677942\|gb\|AAF59405.4\| unc-13, isoform C [Drosophila melanogaster] [NCBI NR] The gene unc-13 is referred to in FlyBase by the symbol Dmel\unc-13 (CG2999, FBgn0025726). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:891551..925419. It has the cytological map location 102E5-102F1. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; synaptic vesicle exocytosis. 7 alleles are reported. The phenotype of these alleles is annotated with: synaptic vesicle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] type=protein; loc=4:complement(892119..892280,892346..892472,892538..892700,892753..892851,893840..894197,894261..894552,894620..894786,894872..895093,895829..896110,896169..896336,896740..896865,896922..897080,897143..897415,897496..897820,899477..899618 [fly-100309-contam.fasta] unc-13 CG2999-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] CG2999-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=4:complement(892119..892280,892346..892472,892538..892700,892753..892851,893840..894197,894261..894552,894620..894786,894872..895093,895829..896110,896169..896336,896740..896865,896922..897080,897143..897415,897496..897820,899477..899618,903243..903349,903587..903707,903769..903988,904193..904267,906080..906088,906386..906517,919019..923908,923963..923968); ID=FBpp0088306; name=unc-13-PC; parent=FBgn0025726,FBtr0089246; dbxref=GB_protein:AAF59405.3,FlyBase_Annotation_IDs:CG2999-PC,FlyBase:FBpp0088306,GB_protein:AAF59405.4,REFSEQ:NP_726614,GB_protein:AAF59405; MD5=f09bd5df286db5ee6155be820128e6bb; length=2874; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=4:complement(892119..892280,892346..892472,892538..892700,892753..892851,893840..894197,894261..894552,894620..894786,894872..895093,895829..896110,896169..896336,896740..896865,896922..897080,897143..897415,897496..897820,899477..899618,903243..903349,903587..903707,903769..903988,904193..904267,906080..906088,906386..906517,919019..923908,923963..923968); ID=FBpp0088306; name=unc-13-PC; parent=FBgn0025726,FBtr0089246; dbxref=GB_protein:AAF59405.3,FlyBase_Annotation_IDs:CG2999-PC,FlyBase:FBpp0088306,GB_protein:AAF59405.4,REFSEQ:NP_726614,GB_protein:AAF59405; MD5=f09bd5df286db5ee6155be820128e6bb; length=2874; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Unc-13, isoform C OS=Drosophila melanogaster GN=unc-13 PE=2 SV=4 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=4:complement(892119..892280,892346..892472,892538..892700,892753..892851,893840..894197,894261..894552,894620..894786,894872..895093,895829..896110,896169..896336,896740..896865,896922..897080,897143..897415,897496..897820,899477..899618,903243..903349,903587..903707,903769..903988,904193..904267,906080..906088,906386..906517,919019..923908,923963..923968); ID=FBpp0088306; name=unc-13-PC; parent=FBgn0025726,FBtr0089246; dbxref=GB_protein:AAF59405.3,FlyBase_Annotation_IDs:CG2999-PC,FlyBase:FBpp0088306,GB_protein:AAF59405.4,REFSEQ:NP_726614,GB_protein:AAF59405,FlyMine:FBpp0088306,modMine:FBpp0088306; MD5=f09bd5df286db5ee6155be820128e6bb; length=2874; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=4:complement(join(903337..903342,898393..903282,885760..885891,885454..885462,883567..883641,883143..883362,882961..883081,882617..882723,878851..878992,876870..877194,876517..876789,876296..876454,876114..876239,875543..875710,875203..875484,874246..874467,873994..874160,873635..873926,873214..873571,872127..872225,871912..872074,871720..871846,871493..871654)); ID=FBpp0088306; name=unc-13-PC; parent=FBgn0025726,FBtr0089246; dbxref=GB_protein:AAF59405.3,FlyBase_Annotation_IDs:CG2999-PC,FlyBase:FBpp0088306,GB_protein:AAF59405.4,REFSEQ:NP_726614,GB_protein:AAF59405,FlyMine:FBpp0088306,modMine:FBpp0088306; MD5=f09bd5df286db5ee6155be820128e6bb; length=2874; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=4:complement(join(903337..903342,898393..903282,885760..885891,885454..885462,883567..883641,883143..883362,882961..883081,882617..882723,878851..878992,876870..877194,876517..876789,876296..876454,876114..876239,875543..875710,875203..875484,874246..874467,873994..874160,873635..873926,873214..873571,872127..872225,871912..872074,871720..871846,871493..871654)); ID=FBpp0088306; name=unc-13-PC; parent=FBgn0025726,FBtr0089246; dbxref=GB_protein:AAF59405.3,FlyBase_Annotation_IDs:CG2999-PC,FlyBase:FBpp0088306,GB_protein:AAF59405.4,REFSEQ:NP_726614,GB_protein:AAF59405,FlyMine:FBpp0088306,modMine:FBpp0088306; MD5=f09bd5df286db5ee6155be820128e6bb; length=2874; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of H9XVP2, Unc-13, isoform C OS=Drosophila melanogaster GN=unc-13 PE=4 SV=4 [DROME.fasta.20160308] FBpp0088306 type=protein; loc=4:complement(join(903337..903342,898393..903282,885760..885891,885454..885462,883567..883641,883143..883362,882961..883081,882617..882723,878851..878992,876870..877194,876517..876789,876296..876454,876114..876239,875543..875710,875203..875484,874246..874467,873994..874160,873635..873926,873214..873571,872127..872225,871912..872074,871720..871846,871493..871654)); ID=FBpp0088306; name=unc-13-PC; parent=FBgn0025726,FBtr0089246; dbxref=GB_protein:AAF59405.3,FlyBase_Annotation_IDs:CG2999-PC,FlyBase:FBpp0088306,GB_protein:AAF59405.4,REFSEQ:NP_726614,GB_protein:AAF59405,FlyMine:FBpp0088306,modMine:FBpp0088306; MD5=f09bd5df286db5ee6155be820128e6bb; length=2874; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=4:complement(join(903337..903342,898393..903282,885760..885891,885454..885462,883567..883641,883143..883362,882961..883081,882617..882723,878851..878992,876870..877194,876517..876789,876296..876454,876114..876239,875543..875710,875203..875484,874246..874467,873994..874160,873635..873926,873214..873571,872127..872225,871912..872074,871720..871846,871493..871654)); ID=FBpp0088306; name=unc-13-PC; parent=FBgn0025726,FBtr0089246; dbxref=GB_protein:AAF59405.3,FlyBase_Annotation_IDs:CG2999-PC,FlyBase:FBpp0088306,GB_protein:AAF59405.4,REFSEQ:NP_726614,GB_protein:AAF59405,UniProt/TrEMBL:Q9V483,FlyMine:FBpp0088306,modMine:FBpp0088306; MD5=f09bd5df286db5ee6155be820128e6bb; length=2874; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2874 amino acids
Gene Ontology:
Cellular Component:	terminal button [IDA] postsynaptic membrane [IDA] synaptic vesicle [ISS][NAS]
Biological Process:	synaptic vesicle priming [NAS] intracellular signaling pathway [IEA] synaptic transmission [IMP][NAS] synaptic vesicle exocytosis [IMP][ISS] neurotransmitter secretion [NAS]
Molecular Function:	calmodulin binding [TAS] diacylglycerol binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTHYVRHDYF HNTQNGALSS DTSRISYSQI SYETQPSREY FSESYALSNQ GPEECSRVSH  60
   61 LNSDTVLTTV DNSNNSYGYD YLECYGANIQ CDPEEDSVDN WNENTSVVAD QYGLGHNNLN 120
  121 CTSSKLLPKL PNIENGRGSS NACAPQMDVK FNTKGMCIKI DHSYGVCMAK AHDFVGRLSP 180
  181 SDYQNILGNN LNGYAGCAYS STFLDNAMSS APLRVLPQSP RCSSYLGRNI IGFNADAAQR 240
  241 DGRGFDTDQT DAMGSESSTY EVYEKMQRPY TSMLPLDYSD YQEGCYNTDN LSTYSDTPPS 300
  301 NNTQLKRQMQ RKISLMMAMT TASVIASGEI RVPVHSKQSK KSTEIQTDSI IGNTISTNAA 360
  361 ARDLDRCLAT ESCEVIVDTR DSGSVTSFPS SAVTAITKTR KLPKVLPTPL CKSSRHPITI 420
  421 ATDALSSSYT SDPLPEKSHR PKQLPKLPIS LPQSNDRASL NSNWATPPAP DALPFNSFDH 480
  481 KSASSPTPTT TITKDTETTS YLVETDFIGA RHNALYQYDS KEPNIVFSDK SVEAEHSPTW 540
  541 TPLSPIQSKQ SPCPPVALPS NIMQNVSLTC HLPEIEATRS DIEREPESSS IEPILEIEKL 600
  601 ADPYSGPGSA LFNISEYLKP YTLNKPILSE EKKNHIANAA STSTTTPLNI TSDDEFSSYS 660
  661 NKWTSTCVNF QPLDVESSLN ISLKVNAGTN QAELLMTPLK SSTPLFISSN GTSDNFNLRK 720
  721 SSPPDSAFTT TVNVNSFETV LVSGSQTASP SPSNLKSPPS IAPLLSYSDY MKQFELPELP 780
  781 QPIMDLSEND TATQSDSFNV INNTLTNADN LNSYNQMDVE SKSSLQLPSY SSESFDPCSV 840
  841 PSFSIKNKEY KIVEKLDSLS NVESVESPKT LVSPVNPLNC SKLLPGTESI VSNDVAFDDT 900
  901 FYDSFNVDIK ELTAFVDHVA PEDGLYNFPN DKTSVEFSFD KTEDTIDMNQ NLSSGECGYY 960
  961 KPSQAQQKAS VVASAASSVL DGISKGLKGG LDGVFSGVSS TVDVTQSNPS SKRGFSFNLA1020
 1021 SKIVPSVGGL LTSTSSTSIK QTGSETNPTL ILISPENVSS RNSNYIPTTS PSCTQKNGEE1080
 1081 NLYSATVHNK STKSNSYYNE VGEISSTLVR NVCDSYDNSY DEMILTNEMV NIGMLDSESE1140
 1141 FGLIENSYSY QVPDNEQIDS VNSYNNKTQN VTNNGIEKAN TKNKPVPLHD PPTKKASTVG1200
 1201 MFGSILGKAA AAVQSATQAV NQSASSVASV VAQKPTIVPR TNNVLLLSSV CSPNEIKRNS1260
 1261 SSVEFDSEYG YQMPDVESLS SHYANTGGDY DNSNMKIHEF GTYADDRPYA DYHTNGNQSQ1320
 1321 FKEEAVIPGE PEVINTNILP IGPQATGKKL PTVNGKSALL IKQMPTEVYD DESDTDELDV1380
 1381 SPSTGKVPSY SIYSEQEDYY MDLQQTTPSI QPNGFYEQVN NGYDYREDYF NEEDEYKYLE1440
 1441 QQREQEEHNQ PKNKKYLKQA KISKIQPPSL DFIDVGQDDD FIYDNYHSED DSGNYLEGSS1500
 1501 SGSVGPIEGS IIKVDSNIEA SFASLNKKSD SFTPTNDSLQ KHDTVIGEST TKLTRLRTEK1560
 1561 MCPDVDEEDE NLSDHVSDLT DLSKLISQKK KTLLRGETEE VVGGHMQVLR QTEITARQRW1620
 1621 HWAYNKIIMQ LNNGGGPGEV GLRTNGHPGD NPFYSNIDSM PDIRPRRKSI PLVSELVLKT1680
 1681 MAATKRNAGL TSAVPRATLN DEDLKMHVYK KALQALIYPI SSTTPHNFLL WTATSPTYCY1740
 1741 ECEGLLWGIA RQGVRCTECG VKCHEKCKDL LNADCLQRAA EKSSKHGAED KANSIITAMK1800
 1801 DRMKQREREK PEIFELIRAV FSVEEKSHAG HMKAVKQSVL DGTSKWSAKI AITVICAQGL1860
 1861 IAKDKSGTSD PYVTVQVSKV KKRTRTMPQE LNPVWNEKFH FECHNSSDRI KVRVWDEDND1920
 1921 LKSKLRQKLT RESDDFLGQT IIEVRTLSGE MDVWYNLEKR TDKSAVSGAI RLHISVEIKG1980
 1981 EEKVAPYHVQ YTCLHENLFH YLCEENTGMV KLPTQKGDDA WKLYFDEIPE EIVDEFSMRY2040
 2041 GIENIYQAMT HFHCLSAKYL CPGVPAVMST LLANINAYYA HTTASSAVSA SDRFAASNFG2100
 2101 KEKFVKLLDQ LHNSLRIDLS MYRNNFPASS PEKLMDLKST VDLLTSITFF RMKVQELSSP2160
 2161 PRASTVVKDC VKACLRSTYQ FLFENCYELY NREFQVDPNE AKRAPDDHEP KLDSVDFWHK2220
 2221 LIALIVSVID EDKNSYGTVL NQFPQELNIG QLSASSMWHL FAVDMKYALE EHEQHRLCKS2280
 2281 SAYMNLHFRV KWLYSNYVKE VPPYKGAVPD YPAWFEPFVM QWLNENDDVS LEYLHGAFKR2340
 2341 DKKDGFQKSS EHALFSNSVV DVFTQLTQCF DVVSKLECPD PEIWKRYMRR FAKTIVKVLI2400
 2401 AYADIVKLEF PEHMKDERIA CILMNNIQQL RVQLEKMFES MGGDKLEEDA ANILKELQQN2460
 2461 LNSALDDLAS QFAISLEPRI TQSVRELGDM LLSIKGGSGT LAAGNLAAQR NAVAVEADEV2520
 2521 LRPLMDLLDG SLTLYAQSCE KTVLKRLLKE LWKIVMRILE KTIVLPPMTD KTMMFKHLTD2580
 2581 NAKNLASNAK IEDMGRLFKS HMAGKQDVKS ALSGVMDISK EVEKNLSPKQ CAVLDVALDT2640
 2641 IKQYFHAGGN GLKKTFLEKS PELQSLRYAL SLYTQMTDTL IKTFISSQVH EVDLENSEES2700
 2701 VGEISVQIDL FSHPGTGEHK VNVKVVAAND LKWQIPSGMF RPFVDINLIG PHLQEKKRKF2760
 2761 ATKSKSNNWS PKYNESFSFT IGNEEQLDFF ELHICVKDYC FARDDRLVGV AVIPLKDISE2820
 2821 KGSVACWLPL MRRIEMDETG WTILRILSQR NNDEVAKEFV KLKSEIRQEP TMGT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Protein Overview: unc-13-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: