Protein Overview: SHIP1_MOUSE

General Information:
Name(s) found:	SHIP1_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|74138078\|dbj\|BAE25436.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|158853999\|ref\|NP_034696.2\| inositol polyphosphate-5-phosphatase D isoform 1 [Mus musculus] [NCBI NR] gi\|158564032\|sp\|Q9ES52.2\|SHIP1_MOUSE RecName: Full=Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; AltName: Full=SH2 domain-containing inositol-5'-phosphatase 1; AltName: Full=SH2 domain-containing inositol phosphatase 1; Short=SHIP-1; AltName: [NCBI NR] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Mus musculus GN=Inpp5d PE=1 SV=2 [Swiss-Prot] Tax_Id=10090 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F420002E15 product:inositol polyphosphate-5-phosphatase D, full insert sequence [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] inositol polyphosphate-5-phosphatase D isoform 1 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (SH2 domain-containing inositol-5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (p150Ship) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Inpp5d Isoform 1 of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Inpp5d 6 days neonate spleen cDNA, RIKEN full-length enriched library, clone:F420002E15 product:inositol polyphosphate-5-phosphatase D, full insert sequence [zeeyong.fasta] Tax_Id=10090 Gene_Symbol=Inpp5d Isoform 1 of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 ENSMUSG00000026288 IPI00120516 IPI00124504 IPI00856529 IPI00857938 IPI00857008 IPI00857200 [IPIxENS.MOUSE_plus_REVERSE.fasta] phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 isoform 1 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta] IPI:IPI00120516.2\|SWISS-PROT:Q9ES52-1\|ENSEMBL:ENSMUSP00000044647\|REFSEQ:NP_034696 Tax_Id=10090 Gene_Symbol=Inpp5d Isoform 1 of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 [ipi.MOUSE.fasta.20090209] Isoform 1 of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 OS=Mus musculus GN=Inpp5d [011711_HMR.fasta] Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 OS=Mus musculus GN=Inpp5d PE=1 SV=2 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta] sp\|Q9ES52\|SHIP1_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Mus musculus GN=Inpp5d PE=1 SV=2 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1191 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [UNKNOWN] cytoplasm [IEA] membrane [IEA] plasma membrane [UNKNOWN]
Biological Process:	negative regulation of interleukin-6 biosynthetic process [IMP] determination of adult lifespan [IMP] negative regulation of cell proliferation [IDA] positive regulation of lymphocyte differentiation [IMP] negative regulation of bone resorption [IMP] positive regulation of erythrocyte differentiation [IMP] negative regulation of neutrophil differentiation [IMP] positive regulation of B cell differentiation [IMP] negative regulation of monocyte differentiation [IMP] intracellular signaling pathway [IMP] negative regulation of signal transduction [IMP] negative regulation of B cell proliferation [IMP] positive regulation of apoptosis [IMP] apoptosis [IEA] immunoglobulin mediated immune response [IMP] negative regulation of osteoclast differentiation [IMP] negative regulation of B cell activation [IMP] negative regulation of immune response [IMP] negative regulation of granulocyte differentiation [IMP]
Molecular Function:	inositol or phosphatidylinositol phosphatase activity [IEA] protein binding [IPI] phosphatidylinositol trisphosphate phosphatase activity [IDA] SH3 domain binding [IDA] inositol-4,5-bisphosphate 5-phosphatase activity [UNKNOWN] inositol-polyphosphate 5-phosphatase activity [IDA] PTB domain binding [IDA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR NCVYTYRILP  60
   61 NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL QYPVPLEEED AIDEAEEDTV 120
  121 ESVMSPPELP PRNIPMSAGP SEAKDLPLAT ENPRAPEVTR LSLSETLFQR LQSMDTSGLP 180
  181 EEHLKAIQDY LSTQLLLDSD FLKTGSSNLP HLKKLMSLLC KELHGEVIRT LPSLESLQRL 240
  241 FDQQLSPGLR PRPQVPGEAS PITMVAKLSQ LTSLLSSIED KVKSLLHEGS ESTNRRSLIP 300
  301 PVTFEVKSES LGIPQKMHLK VDVESGKLIV KKSKDGSEDK FYSHKKILQL IKSQKFLNKL 360
  361 VILVETEKEK ILRKEYVFAD SKKREGFCQL LQQMKNKHSE QPEPDMITIF IGTWNMGNAP 420
  421 PPKKITSWFL SKGQGKTRDD SADYIPHDIY VIGTQEDPLG EKEWLELLRH SLQEVTSMTF 480
  481 KTVAIHTLWN IRIVVLAKPE HENRISHICT DNVKTGIANT LGNKGAVGVS FMFNGTSLGF 540
  541 VNSHLTSGSE KKLRRNQNYM NILRFLALGD KKLSPFNITH RFTHLFWLGD LNYRVELPTW 600
  601 EAEAIIQKIK QQQYSDLLAH DQLLLERKDQ KVFLHFEEEE ITFAPTYRFE RLTRDKYAYT 660
  661 KQKATGMKYN LPSWCDRVLW KSYPLVHVVC QSYGSTSDIM TSDHSPVFAT FEAGVTSQFV 720
  721 SKNGPGTVDS QGQIEFLACY ATLKTKSQTK FYLEFHSSCL ESFVKSQEGE NEEGSEGELV 780
  781 VRFGETLPKL KPIISDPEYL LDQHILISIK SSDSDESYGE GCIALRLETT EAQHPIYTPL 840
  841 THHGEMTGHF RGEIKLQTSQ GKMREKLYDF VKTERDESSG MKCLKNLTSH DPMRQWEPSG 900
  901 RVPACGVSSL NEMINPNYIG MGPFGQPLHG KSTLSPDQQL TAWSYDQLPK DSSLGPGRGE 960
  961 GPPTPPSQPP LSPKKFSSST ANRGPCPRVQ EARPGDLGKV EALLQEDLLL TKPEMFENPL1020
 1021 YGSVSSFPKL VPRKEQESPK MLRKEPPPCP DPGISSPSIV LPKAQEVESV KGTSKQAPVP1080
 1081 VLGPTPRIRS FTCSSSAEGR MTSGDKSQGK PKASASSQAP VPVKRPVKPS RSEMSQQTTP1140
 1141 IPAPRPPLPV KSPAVLQLQH SKGRDYRDNT ELPHHGKHRQ EEGLLGRTAM Q

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: SHIP1_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: