Protein Overview: METH_MOUSE

General Information:
Name(s) found:	METH_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|82949610\|ref\|XP_138431.5\| PREDICTED: 5-methyltetrahydrofolate-homocysteine methyltransferase isoform 1 [Mus musculus] [NCBI NR] gi\|82949594\|ref\|XP_915550.1\| PREDICTED: similar to 5-methyltetrahydrofolate-homocysteine methyltransferase isoform 1 [Mus musculus] [NCBI NR] gi\|166201366\|sp\|A6H5Y3.1\|METH_MOUSE RecName: Full=Methionine synthase; AltName: Full=5-methyltetrahydrofolate--homocysteine methyltransferase; AltName: Full=Vitamin-B12 dependent methionine synthase; Short=MS [NCBI NR] gi\|148878238\|gb\|AAI45686.1\| 5-methyltetrahydrofolate-homocysteine methyltransferase [Mus musculus] [NCBI NR] gi\|148878234\|gb\|AAI45684.1\| 5-methyltetrahydrofolate-homocysteine methyltransferase [Mus musculus] [NCBI NR] gi\|124487479\|ref\|NP_001074597.1\| 5-methyltetrahydrofolate-homocysteine methyltransferase [Mus musculus] [NCBI NR] Methionine synthase OS=Mus musculus GN=Mtr PE=1 SV=1 [Swiss-Prot] Tax_Id=10090 PREDICTED: similar to 5-methyltetrahydrofolate-homocysteine methyltransferase [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] PREDICTED: similar to 5-methyltetrahydrofolate-homocysteine methyltransferase [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] PREDICTED: 5-methyltetrahydrofolate-homocysteine methyltransferase [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] PREDICTED: similar to 5-methyltetrahydrofolate-homocysteine methyltransferase isoform 1 [Mus musculus] [NCBI-RefSeq_mouse_na_03-19-2007_reversed.fasta] 5-methyltetrahydrofolate-homocysteine methyltransferase [Mus musculus] [NCBI-RefSeq_mouse_na_03-19-2007_reversed.fasta] Methionine synthase (5-methyltetrahydrofolate--homocysteine methyltransferase) (Vitamin-B12 dependent methionine synthase) (MS) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Mtr Methionine synthase [mouse-ipi-250309-contam.fasta] PREDICTED: 5-methyltetrahydrofolate-homocysteine methyltransferase isoform 1 [Mus musculus] [nr-271106-contam.fasta] Tax_Id=10090 Gene_Symbol=Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [zeeyong.fasta] Tax_Id=10090 Gene_Symbol=Mtr Methionine synthase ENSMUSG00000021311 IPI00755605 IPI00403447 [IPIxENS.MOUSE_plus_REVERSE.fasta] methionine synthase [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta] IPI:IPI00755605.2\|SWISS-PROT:A6H5Y3\|ENSEMBL:ENSMUSP00000097442\|REFSEQ:NP_001074597 Tax_Id=10090 Gene_Symbol=Mtr Methionine synthase [ipi.MOUSE.fasta.20090209] Methionine synthase OS=Mus musculus GN=Mtr [011711_HMR.fasta] Methionine synthase OS=Mus musculus GN=Mtr PE=2 SV=1 [UniProt_mouse_sprotvarsplic_11-08-2010_reversed.fasta] sp\|A6H5Y3\|METH_MOUSE Methionine synthase OS=Mus musculus GN=Mtr PE=2 SV=1 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1253 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [UNKNOWN] cytoplasm [IEA] intracellular [IEA]
Biological Process:	pteridine and derivative metabolic process [IEA] methionine biosynthetic process [UNKNOWN][IMP] cellular amino acid biosynthetic process [IEA] tetrahydrofolate metabolic process [UNKNOWN] protein amino acid methylation [UNKNOWN] homocysteine metabolic process [UNKNOWN] cellular metabolic process [IEA]
Molecular Function:	methionine synthase activity [UNKNOWN][IMP] zinc ion binding [IEA] metal ion binding [IEA] cobalamin binding [IEA] methyltransferase activity [UNKNOWN] transferase activity [IEA] amino acid binding [UNKNOWN] folic acid binding [UNKNOWN] homocysteine S-methyltransferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTLQDEIE AILRKRIMVL DGGMGTMIQR YKLSEEHFQG QEFKDHSRPL KGNNDILSIT  60
   61 QPDIIYQIHK EYLLAGADII ETNTFSSTSI AQADYGLEHL AYRMNKCSAD VARKAAEEIT 120
  121 LQTGVKRFVA GALGPTNKTL SVSPSVERPD YRNITFDELV DAYQEQAKGL LDGRVDILLI 180
  181 ETIFDTANAK AALFAIQNLF EENYAPPRPI FISGTIVDKS GRTLSGQTGE AFVTSVSHSD 240
  241 PLCIGLNCSL GAAEMRPFIE TIGKCTTAYV LCYPNAGLPN TFGDYDETPS TMATHLKDFA 300
  301 VDGLVNIVGG CCGSTPDHIR EIAEAVKKCK PRVPPASVFE GHMLLSGLEP FRIGPYTNFV 360
  361 NIGERCNVAG SRKFAKLIMA GNYEEALSIA KAQVEMGAQV LDINMDDGML DGPSAMTRFC 420
  421 NSIASEPDIA KVPLCIDSSN FAVIEAGLKC CQGKCIVNSI SLKEGEGDFL EKARKIKKFG 480
  481 AAVVVMAFDE EGQATETDVK VNVCTRAYHL LVDKVGFNPN DIIFDPNILT IGTGMEEHNL 540
  541 YAINFIHATR VIKETLPGVR ISGGLSNLSF SFRGMEAIRE AMHGVFLYHA IKFGMDMGIV 600
  601 NAGNLPVYDA IHKDLLQLCE DLIWNKDSEA TEKLLRYAQT HGTGGKKVIQ TDEWRNGSIE 660
  661 ERLEYALVKG IEKHIVEDTE EARLNGEKYP RPLNIIEGPL MNGMKVVGDL FGAGKMFLPQ 720
  721 VIKSARVMKK AVGHLIPFME KEREEARLIN GSVEEEDPYQ GTIVLATVKG DVHDIGKNIV 780
  781 GVVLACNNFR VIDLGVMTPC DKILQAALDH KADIIGLSGL ITPSLDEMIF VAKEMERLAI 840
  841 KIPLLIGGAT TSRTHTAVKI APRYSAPVIH VLDASKSVVV CSQLLDENLR DDYFEEILEE 900
  901 YEDIRQDHYE SLKERKYVPL SQARKHGFHI DWLSEPHPVK PTFIGTQVFE DYNLQKLVDY 960
  961 IDWKPFFDVW QLRGKYPNRG FPKIFNDKAV GEEARKVYND AQNMLNILIS QKKLQARGVV1020
 1021 GFWPAQSVQD DIHLYAEGVV PQAAEPIATF YGLRQQAEKD SSSTDPYHCL SDFIAPLHSG1080
 1081 VCDYLGLFAV ACFGVEELSK TYEDDGDDYS SIMVKALGDR LAEAFAEELH ERVRRELWAY1140
 1141 SRSEQLGVPD LRRLRYEGIR PAPGYPSQPD HTEKLTMWRL ASIEQATGIR LTESLAMAPA1200
 1201 SAVSGLYFSN VKAKYFAVGK ISKDQTEDYA LRKNMPVAEV EKWLGPILGY DTD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Protein Overview: METH_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: