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Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate. Catalysis of the transfer of a methyl group to an acceptor molecule. Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine. Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: methionine synthase activity
Acc: GO:0008705
Aspect: Molecular Function
Desc: Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
Synonyms:
  • B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity
  • N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity
  • B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity
  • tetrahydrofolate methyltransferase activity
  • tetrahydropteroylglutamic methyltransferase activity
  • N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity
  • 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity
  • MetH
  • N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity
  • vitamin B12 methyltransferase activity
  • 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
  • methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity
  • N5-methyltetrahydrofolate methyltransferase activity
  • 5-methyltetrahydrofolate--homocysteine transmethylase activity
  • N-methyltetrahydrofolate:L-homocysteine methyltransferase activity
  • tetrahydropteroylglutamate methyltransferase activity
  • methionine synthase (cobalamin-dependent) activity
  • N(5)-methyltetrahydrofolate methyltransferase activity
  • N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity
  • 5-methyltetrahydrofolate--homocysteine S-methyltransferase activity
  • cobalamin-dependent methionine synthase activity
Proteins in PDR annotated with:
   This term: 12 [Search]
   Term or descendants: 12 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008705 - methionine synthase activity (interactive image map)

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