Protein Overview: PLEK_RAT

General Information:
Name(s) found:	PLEK_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|84029399\|sp\|Q4KM33.1\|PLEK_RAT RecName: Full=Pleckstrin [NCBI NR] gi\|71043674\|ref\|NP_001020921.1\| pleckstrin [Rattus norvegicus] [NCBI NR] gi\|68534565\|gb\|AAH98846.1\| Pleckstrin [Rattus norvegicus] [NCBI NR] gi\|149044714\|gb\|EDL97900.1\| pleckstrin [Rattus norvegicus] [NCBI NR] Pleckstrin OS=Rattus norvegicus GN=Plek PE=1 SV=1 [Swiss-Prot] Tax_Id=10116 Pleckstrin [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 PREDICTED: similar to pleckstrin [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta] Pleckstrin [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] pleckstrin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Pleckstrin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Plek Pleckstrin [rat-ipi-250309-contam.fasta] Pleckstrin OS=Rattus norvegicus GN=Plek [011711_HMR.fasta] Pleckstrin OS=Rattus norvegicus GN=Plek PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	350 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [UNKNOWN][IEA] soluble fraction [UNKNOWN][IEA] cytoplasm [UNKNOWN][IEA] cytosol [UNKNOWN] ruffle membrane [UNKNOWN][IEA] extracellular region [UNKNOWN]
Biological Process:	positive regulation of platelet activation [IEA] protein kinase C signaling cascade [IEA] cell projection organization [UNKNOWN] regulation of cell diameter [UNKNOWN][IEA] hemopoietic progenitor cell differentiation [UNKNOWN][IEA] negative regulation of G-protein coupled receptor protein signaling pathway [UNKNOWN] platelet degranulation [UNKNOWN] cortical actin cytoskeleton organization [UNKNOWN][IEA] thrombin receptor signaling pathway [UNKNOWN][IEA] integrin-mediated signaling pathway [UNKNOWN][IEA] inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway [UNKNOWN][IEA] positive regulation of actin filament depolymerization [UNKNOWN][IEA] positive regulation of inositol-polyphosphate 5-phosphatase activity [UNKNOWN][IEA] ruffle organization [UNKNOWN][IEA] protein secretion by platelet [IEA] vesicle docking during exocytosis [IEA] phosphoinositide metabolic process [UNKNOWN][IEA] negative regulation of inositol phosphate biosynthetic process [UNKNOWN][IEA] positive regulation of actin filament bundle assembly [UNKNOWN][IEA] positive regulation of integrin activation [IEA] platelet aggregation [IEA] actin cytoskeleton reorganization [UNKNOWN][IEA]
Molecular Function:	protein kinase C binding [UNKNOWN][IEA] protein binding [UNKNOWN][IEA] protein homodimerization activity [UNKNOWN][IEA] phosphatidylinositol-3,4-bisphosphate binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNNPKGMIPL KGSTLTSPCQ  60
   61 DFGKRMFVLK ITTTKQQDHF FQAAYLEERD AWVRDIKKAI KCIEGGQKFA RKSTRRSIRL 120
  121 PETIDLGALY LSMKDPEKGI KELNLEKDKK VFNHCFTGSG VIDWLVSNKL VRNRQEGLMI 180
  181 SASLLSEGYL QPASDLSKNA ADGIAENPFL DNPDAFYYFP DSGFFCEENS SDDDIILKEE 240
  241 FRGIIIKQGC LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGGEDPLGAI HLRGCVVTSV 300
  301 ESNPDGKKSD EENLFEIITA DEVHYYMQAA TAKERTEWIK AIQVASRTGK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PLEK_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: