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Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of a signaling pathway. Any process that stops, prevents or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. A signaling pathway that results in preventing the activation of phospholipase C in response to a signal. Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. Any process that stops, prevents or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands. The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. Any process that stops, prevents or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands. The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway. Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of G-protein coupled receptor protein signaling pathway
Acc: GO:0045744
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.
Synonyms:
  • negative regulation of G protein coupled receptor protein signalling pathway
  • negative regulation of G-protein-coupled receptor protein signaling pathway
  • down-regulation of G-protein coupled receptor protein signaling pathway
  • negative regulation of G-protein coupled receptor protein signalling pathway
  • negative regulation of G-protein-coupled receptor protein signalling pathway
  • inhibition of G-protein coupled receptor protein signaling pathway
  • negative regulation of GPCR protein signalling pathway
  • negative regulation of GPCR protein signaling pathway
  • downregulation of G-protein coupled receptor protein signaling pathway
  • negative regulation of G protein coupled receptor protein signaling pathway
  • down regulation of G-protein coupled receptor protein signaling pathway
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 36 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045744 - negative regulation of G-protein coupled receptor protein signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle