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Protein Overview: PLEK_RAT

General Information:
Name(s) found: PLEK_RAT [Swiss-Prot]
Description(s) found:
Found 13 descriptions.
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  • Pleckstrin OS=Rattus norvegicus GN=Plek PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN][IEA]
    soluble fraction [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IEA]
    cytosol [UNKNOWN]
    ruffle membrane [UNKNOWN][IEA]
    extracellular region [UNKNOWN]
    Biological Process: positive regulation of platelet activation [IEA]
    protein kinase C signaling cascade [IEA]
    cell projection organization [UNKNOWN]
    regulation of cell diameter [UNKNOWN][IEA]
    hemopoietic progenitor cell differentiation [UNKNOWN][IEA]
    negative regulation of G-protein coupled receptor protein signaling pathway [UNKNOWN]
    platelet degranulation [UNKNOWN]
    cortical actin cytoskeleton organization [UNKNOWN][IEA]
    thrombin receptor signaling pathway [UNKNOWN][IEA]
    integrin-mediated signaling pathway [UNKNOWN][IEA]
    inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway [UNKNOWN][IEA]
    positive regulation of actin filament depolymerization [UNKNOWN][IEA]
    positive regulation of inositol-polyphosphate 5-phosphatase activity [UNKNOWN][IEA]
    ruffle organization [UNKNOWN][IEA]
    protein secretion by platelet [IEA]
    vesicle docking during exocytosis [IEA]
    phosphoinositide metabolic process [UNKNOWN][IEA]
    negative regulation of inositol phosphate biosynthetic process [UNKNOWN][IEA]
    positive regulation of actin filament bundle assembly [UNKNOWN][IEA]
    positive regulation of integrin activation [IEA]
    platelet aggregation [IEA]
    actin cytoskeleton reorganization [UNKNOWN][IEA]
    Molecular Function: protein kinase C binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IEA]
    protein homodimerization activity [UNKNOWN][IEA]
    phosphatidylinositol-3,4-bisphosphate binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPKRIREGY LVKKGSVFNT WKPMWVVLLE DGIEFYKKKS DNNPKGMIPL KGSTLTSPCQ  60
   61 DFGKRMFVLK ITTTKQQDHF FQAAYLEERD AWVRDIKKAI KCIEGGQKFA RKSTRRSIRL 120
  121 PETIDLGALY LSMKDPEKGI KELNLEKDKK VFNHCFTGSG VIDWLVSNKL VRNRQEGLMI 180
  181 SASLLSEGYL QPASDLSKNA ADGIAENPFL DNPDAFYYFP DSGFFCEENS SDDDIILKEE 240
  241 FRGIIIKQGC LLKQGHRRKN WKVRKFILRE DPAYLHYYDP AGGEDPLGAI HLRGCVVTSV 300
  301 ESNPDGKKSD EENLFEIITA DEVHYYMQAA TAKERTEWIK AIQVASRTGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle