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Protein Overview: FBpp0305533

General Information:
Name(s) found: FBpp0305533 [FlyBase]
Description(s) found:
Found 21 descriptions.
SHOW ALL
  • type=protein; loc=X:join(1891620..1894438,1894587..1894735,1894804..1896192,1896268..1896386,1896493..1896573); ID=FBpp0305533; name=Hr4-PC; parent=FBgn0264562,FBtr0333341; dbxref=REFSEQ:NP_001033823,GB_protein:ABC67166,FlyBase_Annotation_IDs:CG43934-PC,FlyBase:FBpp0305533; MD5=cf153e2217b30a5c72d80238d053efb8; length=1518; release=r5.56; species=Dmel; [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1518 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    Biological Process: pupariation [IMP]
    steroid hormone receptor signaling pathway [IMP]
    regulation of transcription, DNA-dependent [IEA]
    metamorphosis [NAS]
    growth [IMP]
    Molecular Function: zinc ion binding [IEA]
    transcription factor activity [IEA]
    ligand-dependent nuclear receptor activity [IMP][ISS][NAS]
    steroid hormone receptor activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLSRGPYSE LDKMSLFQDL KLKRRKIDSR CSSDGESIAD TSTSSPDLLA PMSPKLCDSG  60
   61 SAGASLGASL PLPLALPLPM ALPLPMSLPL PLTAASSAVT VSLAAVVAAV AETGGAGAGG 120
  121 AGTAVTASGA GPCVSTSSTT AAAATSSTSS LSSSSSSSSS TSSSTSSASP TAGASSTATC 180
  181 PASSSSSSGN GSGGKSGSIK QEHTEIHSSS SAISAAAAST VMSPPPAEAT RSSPATPEGG 240
  241 GPAGDGSGAT GGGNTSGGST AGVAINEHQN NGNGSGGSSR ASPDSLEEKP STTTTTGRPT 300
  301 LTPTNGVLSS ASAGTGISTG SSAKLSEAGM SVIRSVKEER LLNVSSKMLV FHQQREQETK 360
  361 AVAAAAAAAA AGHVTVLVTP SRIKSEPPPP ASPSSTSSTQ RERERERDRE RDRERERERD 420
  421 RDREREREQS ISSSQQHLSR VSASPPTQLS HGSLGPNIVQ THHLHQQLTQ PLTLRKSSPP 480
  481 TEHLLSQSMQ HLTQQQAIHL HHLLGQQQQQ QQASHPQQQQ QQQHSPHSLV RVKKEPNVGQ 540
  541 RHLSPHHQQQ SPLLQHHQQQ QQQQQQQQQH LHQQQQQQQH HQQQPQALAL MHPASLALRN 600
  601 SNRDAAILFR VKSEVHQQVA AGLPHLMQSA GGAAAAAAAA VAAQRMVCFS NARINGVKPE 660
  661 VIGGPLGNLR PVGVGGGNGS GSVQCPSPHP SSSSSSSQLS PQTPSQTPPR GTPTVIMGES 720
  721 CGVRTMVWGY EPPPPSAGQS HGQHPQQQQQ SPHHQPQQQQ QQQQQQSQQQ QQQQQQQSLG 780
  781 QQQHCLSSPS AGSLTPSSSS GGGSVSGGGV GGPLTPSSVA PQNNEEAAQL LLSLGQTRIQ 840
  841 DMRSRPHPFR TPHALNMERL WAGDYSQLPP GQLQALNLSA QQQQWGSSNS TGLGGVGGGM 900
  901 GGRNLEAPHE PTDEDEQPLV CMICEDKATG LHYGIITCEG CKGFFKRTVQ NRRVYTCVAD 960
  961 GTCEITKAQR NRCQYCRFKK CIEQGMVLQA VREDRMPGGR NSGAVYNLYK VKYKKHKKTN1020
 1021 QKQQQQAAQQ QQQQAAAQQQ HQQQQQHQQH QQHQQQQLHS PLHHHHHQGH QSHHAQQQHH1080
 1081 PQLSPHHLLS PQQQQLAAAV AAAAQHQQQQ QQQQQQQQQA KLMGGVVDMK PMFLGPALKP1140
 1141 ELLQAPPMHS PAQQQQQQQQ QQQQQQASPH LSLSSPHQQQ QQQQGQHQNH HQQQGGGGGG1200
 1201 AGGGAQLPPH LVNGTILKTA LTNPSEIVHL RHRLDSAVSS SKDRQISYEH ALGMIQTLID1260
 1261 CDAMEDIATL PHFSEFLEDK SEISEKLCNI GDSIVHKLVS WTKKLPFYLE IPVEIHTKLL1320
 1321 TDKWHEILIL TTAAYQALHG KRRGEGGGSR HGSPASTPLS TPTGTPLSTP IPSPAQPLHK1380
 1381 DDPEFVSEVN SHLSTLQTCL TTLMGQPIAM EQLKLDVGHM VDKMTQITIM FRRIKLKMEE1440
 1441 YVCLKVYILL NKEVELESIQ ERYVQVLRSY LQNSSPQNPQ ARLSELLSHI PEIQAAASLL1500
 1501 LESKMFYVPF VLNSASIR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] MSA 1.189996 View MSA. No confident structure predictions are available.
    2 View Details [135..353] MSA 1.200991 View MSA. No confident structure predictions are available.
    3 View Details [354..648] FFAS03 2.06 No description for 2i1jA was found.
    4 View Details [649..897] deduced N/A No confident structure predictions are available.
    5 View Details [898..1060] PSI-BLAST 29.0 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    6 View Details [1061..1194] deduced N/A No confident structure predictions are available.
    7 View Details [1195..1518] PSI-BLAST 67.0 LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  2.30195937604451 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.20686235000733 bayes_pls_golite062009
  • receptor activity
    		•  2.07573173722434 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.60419100774741 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.28118886948947 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.23834725221597 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • signal transducer activity
    		•  1.19872119297817 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  0.99801784942981 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.74373733735458 bayes_pls_golite062009
  • promoter binding
    		•  0.58091332905515 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • lipid binding
    		•  0.164046651023989 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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