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Protein Overview: tph-1

General Information:
Name(s) found: tph-1 / CE39457 [WormBase]
Description(s) found:
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  • WBGene00006600 locus:tph-1 status:Confirmed UniProt:G5EED8 protein_id:CCD65929.1 [WormBase]
  • gi|82654552|gb|ABB88221.1| Tryptophan hydroxylase protein 1, isoform a [Caenorhabditis elegans] [NCBI NR]
  • gi|4809153|gb|AAD30115.1|AF135186_1 tryptophan hydroxylase [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_495584.2| tryptophan hydroxylase (60.9 kD) (tph-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|115533973|ref|NP_495584.4| TryPtophan Hydroxylase family member (tph-1) [Caenorhabditis elegans] [NCBI NR]
  • tryptophan hydroxylase (60.9 kD) (tph-1) [Caenorhabditis elegans]gi|4809153|gb|AAD30115.1| tryptophan hydroxylase [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE39457 WBGene00006600 locus:tph-1 Biopterin-dependent aromatic amino acid hydroxylase status:Confirmed UniProt:Q9XZD1_CAEEL protein_id:ABB88221.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE39457 WBGene00006600 locus:tph-1 Biopterin-dependent aromatic amino acid hydroxylase status:Confirmed UniProt:Q9XZD1_CAEEL protein_id:ABB88221.1| [wormORF-contam.fasta]
  • CE39457 WBGene00006600 locus:tph-1 Biopterin-dependent aromatic amino acid hydroxylase status:Confirmed TR:Q9XZD1 protein_id:ABB88221.1 [wormpep160-contam.fasta]
  • tryptophan hydroxylase [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • TryPtophan Hydroxylase family member (tph-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Tryptophan hydroxylase protein 1, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE39457 WBGene00006600 locus:tph-1 Biopterin-dependent aromatic amino acid hydroxylase status:Confirmed UniProt:Q9XZD1 protein_id:ABB88221.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE39457 WBGene00006600 locus:tph-1 Biopterin-dependent aromatic amino acid hydroxylase status:Confirmed UniProt:G5EED8 protein_id:CCD65929.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE39457 WBGene00006600 locus:tph-1 status:Confirmed UniProt:G5EED8 protein_id:CCD65929.1 [wormpep246-ecoli-contam.fasta]
  • TryPtophan Hydroxylase OS=Caenorhabditis elegans GN=tph-1 PE=2 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 532 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IDALink to PubMed article]
    Biological Process: serotonin biosynthetic process [IEALink to PubMed article]
    regulation of pharyngeal pumping [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    lipid storage [IMPLink to PubMed article]
    dauer larval development [IGILink to PubMed article][IMPLink to PubMed article]
    aromatic amino acid family metabolic process [IEALink to PubMed article]
    L-phenylalanine catabolic process [IEALink to PubMed article]
    regulation of oviposition [IMPLink to PubMed article]
    determination of adult lifespan [IGILink to PubMed article][IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    catecholamine biosynthetic process [IEALink to PubMed article]
    serotonin biosynthetic process from tryptophan [IMPLink to PubMed article][ISSLink to PubMed article]
    positive regulation of transforming growth factor beta receptor signaling pathway [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: iron ion binding [IEALink to PubMed article]
    phenylalanine 4-monooxygenase activity [IEALink to PubMed article]
    monooxygenase activity [IEALink to PubMed article]
    tyrosine 3-monooxygenase activity [IEALink to PubMed article]
    tryptophan 5-monooxygenase activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSLFQMASA MKFQYYSKKA AGKTMSNSVS MSSDNRMEDF KRRFRRSGSL GIPFVPEEDV  60
   61 KQLFTPTRTV RREASIREGD EEEGVQILTI IVKSSRVSED ISKMIANLPD HTRIKHLETR 120
  121 DSQDGSSKTM DVLLEIELFH YGKQEAMDLM RLNGLDVHEV SSTIRPTAIK EQYTEPGSDD 180
  181 ATTGSEWFPK SIYDLDICAK RVIMYGAGLD ADHPGFKDTE YRQRRMMFAE LALNYKHGEP 240
  241 IPRTEYTSSE RKTWGIIYRK LRELHKKHAC KQFLDNFELL ERHCGYSENN IPQLEDICKF 300
  301 LKAKTGFRVR PVAGYLSARD FLAGLAYRVF FCTQYVRHHA DPFYTPEPDT VHELMGHMAL 360
  361 FADPDFAQFS QEIGLASLGA SEEDLKKLAT LYFFSIEFGL SSDDAADSPV KENGSNHERF 420
  421 KVYGAGLLSS AGELQHAVEG SATIIRFDPD RVVEQECLIT TFQSAYFYTR NFEEAQQKLR 480
  481 MFTNNMKRPF IVRYNPYTES VEVLNNSRSI MLAVNSLRSD INLLAGALHY IL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] PSI-BLAST 40.0 No description for 2qmxA was found.
    2 View Details [79..532] PSI-BLAST 153.0 Phenylalanine hydroxylase N-terminal domain; Phenylalanine hydroxylase, PAH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • tyrosine 3-monooxygenase activity
    		•  10.4963678823868 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
    		•  10.3746889036269 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  4.1759203417536 bayes_pls_golite062009
  • phenylalanine 4-monooxygenase activity
    		•  4.03306427400343 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  3.48670706716817 bayes_pls_golite062009
  • monooxygenase activity
    		•  3.40046054657404 bayes_pls_golite062009
  • tryptophan 5-monooxygenase activity
    		•  2.77661203376054 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.5269324625528 bayes_pls_golite062009
  • binding
    		•  1.94530534071622 bayes_pls_golite062009
  • protein binding
    		•  1.5818067110205 bayes_pls_golite062009
  • ferric iron binding
    		•  1.39368895479267 bayes_pls_golite062009
  • amine binding
    		•  1.23106204610034 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16507349262706 bayes_pls_golite062009
  • catalytic activity
    		•  0.932947046865376 bayes_pls_golite062009
  • DNA binding
    		•  0.395475529920613 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.389893743151944 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle