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Protein Overview: XRN1_YEAST

General Information:
Name(s) found: XRN1_YEAST [Swiss-Prot]
Description(s) found:
  • 5'-3' exoribonuclease 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=XRN1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1528 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIPKFFRYI SERWPMILQL IEGTQIPEFD NLYLDMNSIL HNCTHGNDDD VTKRLTEEEV  60
   61 FAKICTYIDH LFQTIKPKKI FYMAIDGVAP RAKMNQQRAR RFRTAMDAEK ALKKAIENGD 120
  121 EIPKGEPFDS NSITPGTEFM AKLTKNLQYF IHDKISNDSK WREVQIIFSG HEVPGEGEHK 180
  181 IMNFIRHLKS QKDFNQNTRH CIYGLDADLI MLGLSTHGPH FALLREEVTF GRRNSEKKSL 240
  241 EHQNFYLLHL SLLREYMELE FKEIADEMQF EYNFERILDD FILVMFVIGN DFLPNLPDLH 300
  301 LNKGAFPVLL QTFKEALLHT DGYINEHGKI NLKRLGVWLN YLSQFELLNF EKDDIDVEWF 360
  361 NKQLENISLE GERKRQRVGK KLLVKQQKKL IGSIKPWLME QLQEKLSPDL PDEEIPTLEL 420
  421 PKDLDMKDHL EFLKEFAFDL GLFITHSKSK GSYSLKMDLD SINPDETEEE FQNRVNSIRK 480
  481 TIKKYQNAII VEDKEELETE KTIYNERFER WKHEYYHDKL KFTTDSEEKV RDLAKDYVEG 540
  541 LQWVLYYYYR GCPSWSWYYP HHYAPRISDL AKGLDQDIEF DLSKPFTPFQ QLMAVLPERS 600
  601 KNLIPPAFRP LMYDEQSPIH DFYPAEVQLD KNGKTADWEA VVLISFVDEK RLIEAMQPYL 660
  661 RKLSPEEKTR NQFGKDLIYS FNPQVDNLYK SPLGGIFSDI EHNHCVEKEY ITIPLDSSEI 720
  721 RYGLLPNAKL GAEMLAGFPT LLSLPFTSSL EYNETMVFQQ PSKQQSMVLQ ITDIYKTNNV 780
  781 TLEDFSKRHL NKVIYTRWPY LRESKLVSLT DGKTIYEYQE SNDKKKFGFI TKPAETQDKK 840
  841 LFNSLKNSML RMYAKQKAVK IGPMEAIATV FPVTGLVRDS DGGYIKTFSP TPDYYPLQLV 900
  901 VESVVNEDER YKERGPIPIE EEFPLNSKVI FLGDYAYGGE TTIDGYSSDR RLKITVEKKF 960
  961 LDSEPTIGKE RLQMDHQAVK YYPSYIVSKN MHLHPLFLSK ITSKFMITDA TGKHINVGIP1020
 1021 VKFEARHQKV LGYARRNPRG WEYSNLTLNL LKEYRQTFPD FFFRLSKVGN DIPVLEDLFP1080
 1081 DTSTKDAMNL LDGIKQWLKY VSSKFIAVSL ESDSLTKTSI AAVEDHIMKY AANIEGHERK1140
 1141 QLAKVPREAV LNPRSSFALL RSQKFDLGDR VVYIQDSGKV PIFSKGTVVG YTTLSSSLSI1200
 1201 QVLFDHEIVA GNNFGGRLRT NRGLGLDASF LLNITNRQFI YHSKASKKAL EKKKQSNNRN1260
 1261 NNTKTAHKTP SKQQSEEKLR KERAHDLLNF IKKDTNEKNS ESVDNKSMGS QKDSKPAKKV1320
 1321 LLKRPAQKSS ENVQVDLANF EKAPLDNPTV AGSIFNAVAN QYSDGIGSNL NIPTPPHPMN1380
 1381 VVGGPIPGAN DVADVGLPYN IPPGFMTHPN GLHPLHPHQM PYPNMNGMSI PPPAPHGFGQ1440
 1441 PISFPPPPPM TNVSDQGSRI VVNEKESQDL KKFINGKQHS NGSTIGGETK NSRKGEIKPS1500
 1501 SGTNSTECQS PKSQSNAADR DNKKDEST

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..231] Pfam 171.387216 XRN 5'-3' exonuclease N-terminus No confident structure predictions are available.
    2 View Details [232..303] deduced N/A No confident structure predictions are available.
    3 View Details [304..714] MSA 1.021889 View MSA. No confident structure predictions are available.
    4 View Details [715..1528] deduced N/A No confident structure predictions are available.
    5 View Details [865..938] MSA 1.034995 View MSA. No confident structure predictions are available.
    6 View Details [939..1146] deduced N/A No confident structure predictions are available.
    7 View Details [1147..1221] deduced N/A No confident structure predictions are available.
    8 View Details [1222..1528] FFAS03 1.23 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endonuclease activity
    		•  2.8669665385948 bayes_pls_golite062009
  • hydrolase activity
    		•  2.47801245425307 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.24517620525137 bayes_pls_golite062009
  • nuclease activity
    		•  2.0989149357263 bayes_pls_golite062009
  • exonuclease activity
    		•  1.76587867909916 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  1.74349203224875 bayes_pls_golite062009
  • DNA binding
    		•  1.695958856922 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.68917463278047 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.68760157046614 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.49206381939599 bayes_pls_golite062009
  • binding
    		•  1.42234233865461 bayes_pls_golite062009
  • catalytic activity
    		•  1.27951740231695 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.79417076649627 bayes_pls_golite062009
  • protein binding
    		•  0.488078371576565 bayes_pls_golite062009
  • flap endonuclease activity
    		•  0.405877291452351 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.371408632109349 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.267787854683683 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.260397221344929 bayes_pls_golite062009
  • ribonuclease H activity
    		•  0.234391225960316 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.158336939964254 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.097472492148219 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle