Protein Overview: T2EA_YEAST

General Information:
Name(s) found:	T2EA_YEAST [Swiss-Prot]
Description(s) found:	Transcription initiation factor IIE subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TFA1 PE=1 SV=1 [Swiss-Prot]
Organism:	Saccharomyces cerevisiae S288c
Length:	482 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRPIDDIVK NLLKFVVRGF YGGSFVLVLD AILFHSVLAE DDLKQLLSIN KTELGPLIAR  60
   61 LRSDRLISIH KQREYPPNSK SVERVYYYVK YPHAIDAIKW KVHQVVQRLK DDLDKNSEPN 120
  121 GYMCPICLTK YTQLEAVQLL NFDRTEFLCS LCDEPLVEDD SGKKNKEKQD KLNRLMDQIQ 180
  181 PIIDSLKKID DSRIEENTFE IALARLIPPQ NQSHAAYTYN PKKGSTMFRP GDSAPLPNLM 240
  241 GTALGNDSSR RAGANSQATL HINITTASDE VAQRELQERQ AEEKRKQNAV PEWHKQSTIG 300
  301 KTALGRLDNE EEFDPVVTAS AMDSINPDNE PAQETSYQNN RTLTEQEMEE RENEKTLNDY 360
  361 YAALAKKQAK LNKEEEEEEE EEEDEEEEEE EEMEDVMDDN DETARENALE DEFEDVTDTA 420
  421 GTAKTESNTS NDVKQESIND KTEDAVNATA TASGPSANAK PNDGDDDDDD DDDEMDIEFE 480
  481 DV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..219]	Pfam	96.420216	TFIIE alpha subunit No confident structure predictions are available.
2	View Details	[220..482]	MSA	7.070997	View MSA. No confident structure predictions are available.
3	View Details	[167..482]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	5.67074370996647	bayes_pls_golite062009
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
DNA binding	4.84466441605416	bayes_pls_golite062009
nucleic acid binding	4.57954522145536	bayes_pls_golite062009
transcription factor activity	4.12685284895733	bayes_pls_golite062009
binding	4.05190810999633	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.60738445921725	bayes_pls_golite062009
sequence-specific DNA binding	2.3918869755162	bayes_pls_golite062009
transcription activator activity	2.37668609508629	bayes_pls_golite062009
transcription repressor activity	2.22485867684613	bayes_pls_golite062009
DNA-directed RNA polymerase activity	1.82365519759474	bayes_pls_golite062009
RNA polymerase activity	1.82365519759474	bayes_pls_golite062009
protein binding	0.961087148890615	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.66743181561551	bayes_pls_golite062009
nucleotidyltransferase activity	0.237727660028553	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.0360186926687502	bayes_pls_golite062009

2

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	7.54088990789822	bayes_pls_golite062009
DNA-directed RNA polymerase activity	6.31798033897642	bayes_pls_golite062009
RNA polymerase activity	6.31798033897642	bayes_pls_golite062009
nucleotidyltransferase activity	3.73777657415367	bayes_pls_golite062009
transcription regulator activity	3.36253105801209	bayes_pls_golite062009
binding	2.58311326284197	bayes_pls_golite062009
transcription elongation regulator activity	2.03339710864117	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.95080397433956	bayes_pls_golite062009
nucleic acid binding	1.8086747972572	bayes_pls_golite062009
DNA binding	1.76634962183736	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.57988053581899	bayes_pls_golite062009
DNA primase activity	1.01743034310838	bayes_pls_golite062009
protein binding	0.764662055834369	bayes_pls_golite062009
catalytic activity	0.434839928397784	bayes_pls_golite062009

3

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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