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Protein Overview: RRP5_YEAST

General Information:
Name(s) found: RRP5_YEAST [Swiss-Prot]
Description(s) found:
  • rRNA biogenesis protein RRP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRP5 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1729 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVASTKRKRD EDFPLSREDS TKQPSTSSLV RNTEEVSFPR GGASALTPLE LKQVANEAAS  60
   61 DVLFGNESVK ASEPASRPLK KKKTTKKSTS KDSEASSANS DEARAGLIEH VNFKTLKNGS 120
  121 SLLGQISAIT KQDLCITFTD GISGYVNLTH ISEEFTSILE DLDEDMDSDT DAADEKKSKV 180
  181 EDAEYESSDD EDEKLDKSNE LPNLRRYFHI GQWLRCSVIK NTSLEPSTKK SKKKRIELTI 240
  241 EPSSVNIYAD EDLVKSTSIQ CAVKSIEDHG ATLDVGLPGF TGFIAKKDFG NFEKLLPGAV 300
  301 FLGNITKKSD RSIVVNTDFS DKKNKITQIS SIDAIIPGQI VDLLCESITK NGIAGKVFGL 360
  361 VSGVVNVSHL RTFSEEDLKH KFVIGSSIRC RIIACLENKS GDKVLILSNL PHILKLEDAL 420
  421 RSTEGLDAFP IGYTFESCSI KGRDSEYLYL ALDDDRLGKV HSSRVGEIEN SENLSSRVLG 480
  481 YSPVDDIYQL STDPKYLKLK YLRTNDIPIG ELLPSCEITS VSSSGIELKI FNGQFKASVP 540
  541 PLHISDTRLV YPERKFKIGS KVKGRVISVN SRGNVHVTLK KSLVNIEDNE LPLVSTYENA 600
  601 KNIKEKNEKT LATIQVFKPN GCIISFFGGL SGFLPNSEIS EVFVKRPEEH LRLGQTVIVK 660
  661 LLDVDADRRR IIATCKVSNE QAAQQKDTIE NIVPGRTIIT VHVIEKTKDS VIVEIPDVGL 720
  721 RGVIYVGHLS DSRIEQNRAQ LKKLRIGTEL TGLVIDKDTR TRVFNMSLKS SLIKDAKKET 780
  781 LPLTYDDVKD LNKDVPMHAY IKSISDKGLF VAFNGKFIGL VLPSYAVDSR DIDISKAFYI 840
  841 NQSVTVYLLR TDDKNQKFLL SLKAPKVKEE KKKVESNIED PVDSSIKSWD DLSIGSIVKA 900
  901 KIKSVKKNQL NVILAANLHG RVDIAEVFDT YEEITDKKQP LSNYKKDDVI KVKIIGNHDV 960
  961 KSHKFLPITH KISKASVLEL SMKPSELKSK EVHTKSLEEI NIGQELTGFV NNSSGNHLWL1020
 1021 TISPVLKARI SLLDLADNDS NFSENIESVF PLGSALQVKV ASIDREHGFV NAIGKSHVDI1080
 1081 NMSTIKVGDE LPGRVLKIAE KYVLLDLGNK VTGISFITDA LNDFSLTLKE AFEDKINNVI1140
 1141 PTTVLSVDEQ NKKIELSLRP ATAKTRSIKS HEDLKQGEIV DGIVKNVNDK GIFVYLSRKV1200
 1201 EAFVPVSKLS DSYLKEWKKF YKPMQYVLGK VVTCDEDSRI SLTLRESEIN GDLKVLKTYS1260
 1261 DIKAGDVFEG TIKSVTDFGV FVKLDNTVNV TGLAHITEIA DKKPEDLSAL FGVGDRVKAI1320
 1321 VLKTNPEKKQ ISLSLKASHF SKEAELASTT TTTTTVDQLE KEDEDEVMAD AGFNDSDSES1380
 1381 DIGDQNTEVA DRKPETSSDG LSLSAGFDWT ASILDQAQEE EESDQDQEDF TENKKHKHKR1440
 1441 RKENVVQDKT IDINTRAPES VADFERLLIG NPNSSVVWMN YMAFQLQLSE IEKARELAER1500
 1501 ALKTINFREE AEKLNIWIAM LNLENTFGTE ETLEEVFSRA CQYMDSYTIH TKLLGIYEIS1560
 1561 EKFDKAAELF KATAKKFGGE KVSIWVSWGD FLISHNEEQE ARTILGNALK ALPKRNHIEV1620
 1621 VRKFAQLEFA KGDPERGRSL FEGLVADAPK RIDLWNVYVD QEVKAKDKKK VEDLFERIIT1680
 1681 KKITRKQAKF FFNKWLQFEE SEGDEKTIEY VKAKATEYVA SHESQKADE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] deduced N/A No confident structure predictions are available.
    2 View Details [70..231] MSA 2.042991 View MSA. No confident structure predictions are available.
    3 View Details [232..295] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [296..454] MSA 1.105996 View MSA. No confident structure predictions are available.
    5 View Details [455..550] deduced N/A No confident structure predictions are available.
    6 View Details [551..689] PSI-BLAST 56.522879 S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase
    7 View Details [690..785]
    [858..880]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    8 View Details [786..857]
    [881..943]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    9 View Details [944..966]
    [1097..1175]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    10 View Details [967..1096]
    [1176..1369]    		 PSI-BLAST 75.30103 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; S1 RNA-binding domain of polyribonucleotide phosphorylase, PNPase; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 1 and 4; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 6; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
    11 View Details [1370..1528] PSI-BLAST 23.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    12 View Details [1529..1596] PSI-BLAST 23.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    13 View Details [1597..1729] PSI-BLAST 23.69897 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of ribosome
    		•  5.1118741250402 bayes_pls_golite062009
  • structural molecule activity
    		•  4.51553901145182 bayes_pls_golite062009
  • nuclease activity
    		•  3.11657409772275 bayes_pls_golite062009
    		• 3.02322635335914 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.66669472409706 bayes_pls_golite062009
  • exoribonuclease activity
    		•  2.4082195258205 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  2.3619669410791 bayes_pls_golite062009
  • RNA binding
    		•  2.33019817554364 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.12039058720352 bayes_pls_golite062009
  • exonuclease activity
    		•  1.87925169250843 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.74431545836806 bayes_pls_golite062009
  • translation regulator activity
    		•  1.66546288751201 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.61238850131825 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.59628511603826 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.44123900197846 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.19753926150484 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.12235348738959 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10433412699603 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.07288786419238 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.07285050275461 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.07285050275461 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  1.05238432657007 bayes_pls_golite062009
  • endonuclease activity
    		•  0.991569665925888 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.95191912850966 bayes_pls_golite062009
  • binding
    		•  0.762139256580538 bayes_pls_golite062009
  • DNA binding
    		•  0.710663468386339 bayes_pls_golite062009
  • translation elongation factor activity
    		•  0.55678032558705 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.52627345520111 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • transcription factor activity
    		•  0.332903382446869 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.21650406007586 bayes_pls_golite062009
  • ligase activity
    		•  0.148928528645156 bayes_pls_golite062009
  • mRNA binding
    		•  0.10617671731447 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.07404631453071 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009
    2
    Term Confidence Notes
  • structural constituent of ribosome
    		•  5.22538452462352 bayes_pls_golite062009
  • structural molecule activity
    		•  4.65301390020308 bayes_pls_golite062009
  • RNA binding
    		•  3.36396086314433 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.24341202600661 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.16830676862423 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.94887328847363 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.90081280972069 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.53286219413126 bayes_pls_golite062009
    		• 1.49823328757628 bayes_pls_golite062009
  • binding
    		•  1.38311294671926 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.31550811238109 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.07288786419238 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.07285050275461 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.07285050275461 bayes_pls_golite062009
  • transcription termination factor activity
    		•  1.01993495617192 bayes_pls_golite062009
  • DNA binding
    		•  0.86484629764139 bayes_pls_golite062009
  • mRNA binding
    		•  0.650019633484614 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.477960254167 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.39251242706379 bayes_pls_golite062009
  • tRNA-specific ribonuclease activity
    		•  0.383567539949931 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • protein binding
    		•  0.292595239533272 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.1757578095579 bayes_pls_golite062009
  • ligase activity
    		•  0.148928528645156 bayes_pls_golite062009
  • catalytic activity
    		•  0.10089766806364 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.12690485191789 bayes_pls_golite062009
  • RNA binding
    		•  2.0770703064779 bayes_pls_golite062009
  • protein binding
    		•  1.39668540998298 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.26149030245805 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.01193875360949 bayes_pls_golite062009
  • DNA binding
    		•  0.80346414607277 bayes_pls_golite062009
  • transcription factor activity
    		•  0.374364600772076 bayes_pls_golite062009
  • signal sequence binding
    		•  0.0529781042891342 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle