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Protein Overview: MRCKB_RAT

General Information:
Name(s) found: MRCKB_RAT [Swiss-Prot]
Description(s) found:
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  • gi|81174936|sp|Q7TT49.1|MRCKB_RAT RecName: Full=Serine/threonine-protein kinase MRCK beta; AltName: Full=CDC42-binding protein kinase beta; AltName: Full=Myotonic dystrophy kinase-related CDC42-binding kinase beta; Short=Myotonic dystrophy protein kinase- [NCBI NR]
  • gi|76257394|ref|NP_446072.2| Cdc42-binding protein kinase beta [Rattus norvegicus] [NCBI NR]
  • gi|30841498|gb|AAP34403.1| CDC42-binding protein kinase beta [Rattus norvegicus] [NCBI NR]
  • gi|149044095|gb|EDL97477.1| Cdc42 binding protein kinase beta, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • Serine/threonine-protein kinase MRCK beta OS=Rattus norvegicus GN=Cdc42bpb PE=1 SV=1 [Swiss-Prot]
  • CDC42-binding protein kinase beta [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Serine/threonine-protein kinase MRCK beta [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 CDC42-binding protein kinase beta [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta]
  • Serine/threonine-protein kinase MRCK beta (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Cdc42-binding protein kinase beta [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Cdc42 binding protein kinase beta, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 CDC42-BINDING PROTEIN KINASE BETA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Cdc42bpb Serine/threonine-protein kinase MRCK beta [rat-ipi-250309-contam.fasta]
  • Serine/threonine-protein kinase MRCK beta OS=Rattus norvegicus GN=Cdc42bpb [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 1713 amino acids

    Gene Ontology:
    Cellular Component: cell-cell junction [ISS]
    cytoplasm [IEA]
    cell leading edge [ISS]
    Biological Process: protein amino acid phosphorylation [IDA][ISS]
    actin cytoskeleton organization [IMP]
    actin cytoskeleton reorganization [ISS]
    Molecular Function: nucleotide binding [IEA]
    magnesium ion binding [ISS]
    ATP binding [ISS]
    protein binding [UNKNOWN][IPI]
    small GTPase regulator activity [IEA]
    protein serine/threonine kinase activity [IDA][ISS]
    transferase activity [IEA]
    Rho GTPase binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKVRLKKL EQLLLDGPWR NESSLSVETL LDVLVCLYTE CSHSALRRDK YVAEFLEWAK  60
   61 PFTQLVKDMQ LHREDFEIIK VIGRGAFGEV AVVKMKNTER IYAMKILNKW EMLKRAETAC 120
  121 FREERDVLVN GDCQWITALH YAFQDENYLY LVMDYYVGGD LLTLLSKFED KLPEDMARFY 180
  181 IGEMVLAIDS IHQLHYVHRD IKPDNVLLDV NGHIRLADFG SCLKMNDDGT VQSSVAVGTP 240
  241 DYISPEILQA MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 300
  301 QFPSHVTDVS EEAKDLIQRL ICSRERRLGQ NGIEDFKKHA FFEGLNWENI RNLEAPYIPD 360
  361 VSSPSDTSNF DVDDDVLRNI EILPPGSHTG FSGLHLPFIG FTFTTESCFS DRGSLKSMIQ 420
  421 SNTLTKDEDV QRDLENSLQI EAYERRIRRL EQEKLELSRK LQESTQTVQS LHGSTRALGN 480
  481 SNRDKEIKRL NEELERMKSK MADSNRLERQ LEDTVTLRQE HEDSTQRLKG LEKQYRLARQ 540
  541 EKEELHKQLV EASERLKSQT KELKDAHQQR KRALQEFSEL NERMAELRSQ KQKVSRQLRD 600
  601 KEEEMEVAMQ KIDSMRQDIR KSEKSRKELE ARLEDAVAEA SKERKLREHS ESFSKQMERE 660
  661 LETLKVKQGG RGPGATLEHQ QEISKIRSEL EKKVLFYEEE LVRREASHVL EVKNVKKEVH 720
  721 ESESHQLALQ KEVLMLKDKL EKSKRERHSE MEEAIGAMKD KYERERAMLF DENKKLTAEN 780
  781 EKLCSFVDKL TAQNRQLEDE LQDLASKKES VAHWEAQIAE IIQWVSDEKD ARGYLQALAS 840
  841 KMTEELETLR SSSLGSRTLD PLWKVRRSQK LDMSARLELQ SALEAEIRAK QLVHEELRKV 900
  901 KDTSLAFESK LKESEAKNRE LLEEMQSLKK RMEEKFRADT GLKLPDFQDP IFEYFNTAPL 960
  961 AHDLTFRTSS ASDQETQASK LDLSPSVSVA TSTEQQEDAA RSQQRPSTVP LPNTQALAMA1020
 1021 GPKPKAHQFS IKSFPSPTQC SHCTSLMVGL IRQGYACEVC AFSCHVSCKD SAPQVCPIPP1080
 1081 EQSKRPLGVD VQRGIGTAYK GYVKVPKPTG VKKGWQRAYA VVCDCKLFLY DLPEGKSTQP1140
 1141 GVIASQVLDL RDDEFAVSSV LASDVIHATR RDIPCIFRVT ASLLGSPSKT SSLLILTENE1200
 1201 NEKRKWVGIL EGLQAILHKN RLRSQVVHVA QEAYDSSLPL IKTVLAAAIV DGDRIAVGLE1260
 1261 EGLYVIELTR DVIVRAADCK KVYQIELAPK EKLILLLCGR NHHVHLYPWT SFDGAEASNF1320
 1321 DIKLPETKGC QLIATGTLRK SSSTCLFVAV KRLVLCYEIQ RTKPFHRKFN EIVAPGHVQW1380
 1381 MAMFKDRLCV GYPSGFSLLS IQGDGQPLDL VNPADPSLAF LSQQSFDALC AVELKSEEYL1440
 1441 LCFSHMGLYV DPQGRRSRTQ ELMWPAAPVA CSCSSSHVTV YSEYGVDVFD VRTMEWVQTI1500
 1501 GLRRIRPLNS DGSLNLLGCE PPRLIYFKNK FSGTVLNVPD TSDNSKKQML RTRSKRRFVF1560
 1561 KVPEEERLQQ RREMLRDPEL RSKMISNPTN FNHVAHMGPG DGMQVLMDLP LSAAPTAQEE1620
 1621 KQGPAPTGLP RQLPSRNKPY VSWPSSGGSE PGVPVPLRSM SDPDQDFDKE PDSDSTKHST1680
 1681 PSNSSNPSGP PSPNSPHRSQ LPLEGLDQPA CDA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle