YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: gi|6320880|ref|N...

General Information:
Name(s) found: gi|6320880|ref|NP_010959.1| [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
Description(s) found:
  • Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p [Saccharomyces cerevisiae] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVSQIWEFL KPYLQDSRIP LRKFVIDFNK SQKRAPRIAI DAYGWLFECG FIQNIDISPR  60
   61 SRSRSRSPTR SPRDSDIDSS QEYYGSRSYT TTGKAVINFI SRLKELLSLN VEFLLVFDGV 120
  121 MKPSFKRKFN HEQNATTCDD EKEYYSSWEQ HVKNHEVYGN CKGLLAPSDP EFISLVRKLL 180
  181 DLMNISYVIA CGEGEAQCVW LQVSGAVDFI LSNDSDTLVF GGEKILKNYS KFYDDFGPSS 240
  241 ITSHSPSRHH DSKESFVTVI DLPKINKVAG KKFDRLSLLF FSVLLGADYN RGVKGLGKNK 300
  301 SLQLAQCEDP NFSMEFYDIF KDFNLEDLTS ESLRKSRYRL FQKRLYLYCK DHSVELFGRN 360
  361 YPVLLNQGSF EGWPSTVAIM HYFHPIVQPY FDEEVLSDKY INMAGNGHYR NLNFNELKYF 420
  421 LQSLNLPQIS SFDKWFHDSM HEMFLLREFL SIDESDNIGK GNMRITEEKI MNIDGGKFQI 480
  481 PCFKIRYTTF LPNIPISSQS PLKRSNSPSR SKSPTRRQMD IMEHPNSLWL PKYLIPQSHP 540
  541 LVIQYYETQQ LIQKEKEKKG KKSNKSRLPQ KNNLDEFLRK HTSPIKSIGK VGESRKEILE 600
  601 PVRKRLFVDT DEDTSLEEIP APTRLTTVDE HSDNDDDSLI FVDEITNSQS VLDSSPGKRI 660
  661 RDLTQDEQVD VWKDVIEISP IKKSRTTNAE KNPPESGLKS RSSITINARL QGTKMLPPNL 720
  721 TAPRLEREHS SVLDQLVTDA QDTVDRFVAC DSDSSSTIE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122]
    [139..273]
    [321..371]    		 PSI-BLAST 133.512579 Flap endonuclease-1 (Fen-1 nuclease)
    2 View Details [123..138]
    [274..320]    		 PSI-BLAST 133.512579 Flap endonuclease-1 (Fen-1 nuclease)
    3 View Details [372..759] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nuclease activity
    		•  1.01613710322657 bayes_pls_golite062009
  • flap endonuclease activity
    		•  0.82585431543948 bayes_pls_golite062009
  • exonuclease activity
    		•  0.824724356048525 bayes_pls_golite062009
  • binding
    		•  0.689831953215996 bayes_pls_golite062009
  • catalytic activity
    		•  0.608920813710592 bayes_pls_golite062009
  • hydrolase activity
    		•  0.474100428865975 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.456180294825256 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.37506170847971 bayes_pls_golite062009
  • endonuclease activity
    		•  0.313338552386604 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.261085038325444 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.15331824596114 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  0.152177969184321 bayes_pls_golite062009
  • DNA binding
    		•  0.0968248862430132 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle