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Protein Overview: EG11058

General Information:
Name(s) found: ung / EG11058 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • uracil-DNA-glycosylase / Uracil-DNA glycosylase; UDG excises uracil from DNA by base flipping mechanism; prefers ssDNA over dsDNA [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 229 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: DNA repair [IEA]
    base-excision repair [IEA]
    metabolic process [IEA]
    response to DNA damage stimulus [IEA]
    Molecular Function: hydrolase activity, hydrolyzing N-glycosyl compounds [IEA]
    protein binding [IPILink to PubMed article]
    uracil DNA N-glycosylase activity [IEA]
    hydrolase activity, acting on glycosyl bonds [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANELTWHDV LAEEKQQPYF LNTLQTVASE RQSGVTIYPP QKDVFNAFRF TELGDVKVVI  60
   61 LGQDPYHGPG QAHGLAFSVR PGIAIPPSLL NMYKELENTI PGFTRPNHGY LESWARQGVL 120
  121 LLNTVLTVRA GQAHSHASLG WETFTDKVIS LINQHREGVV FLLWGSHAQK KGAIIDKQRH 180
  181 HVLKAPHPSP LSAHRGFFGC NHFVLANQWL EQRGETPIDW MPVLPAESE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] PSI-BLAST 114.0 Uracil-DNA glycosylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.32235853064174 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  4.14707882788321 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  3.89636585289546 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.84444466513934 bayes_pls_golite062009
  • hydrolase activity
    		•  1.91716804176625 bayes_pls_golite062009
  • single-strand selective uracil DNA N-glycosylase activity
    		•  1.65657095637032 bayes_pls_golite062009
  • catalytic activity
    		•  1.59111295908728 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.783383667044285 bayes_pls_golite062009
  • binding
    		•  0.587736812286194 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.381118322219236 bayes_pls_golite062009
  • protein binding
    		•  0.272261244770552 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0311777202379154 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle