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Protein Overview: EG10662

General Information:
Name(s) found: nth / EG10662 [EcoGene]
Description(s) found:
Found 4 descriptions.
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  • DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) / Endonuclease III: DNA N-glycosylase/AP lyase [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 211 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: DNA repair [IEA]
    base-excision repair [IEA]
    metabolic process [IEA]
    response to DNA damage stimulus [IEA]
    Molecular Function: DNA binding [IEA]
    protein binding [IPILink to PubMed article]
    metal ion binding [IEA]
    iron ion binding [IEA]
    catalytic activity [IEA]
    endonuclease activity [IEA]
    lyase activity [IEA]
    DNA-(apurinic or apyrimidinic site) lyase activity [IEA]
    4 iron, 4 sulfur cluster binding [IEA]
    iron-sulfur cluster binding [IEA]
    hydrolase activity, acting on glycosyl bonds [IEA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKAKRLEIL TRLRENNPHP TTELNFSSPF ELLIAVLLSA QATDVSVNKA TAKLYPVANT  60
   61 PAAMLELGVE GVKTYIKTIG LYNSKAENII KTCRILLEQH NGEVPEDRAA LEALPGVGRK 120
  121 TANVVLNTAF GWPTIAVDTH IFRVCNRTQF APGKNVEQVE EKLLKVVPAE FKVDCHHWLI 180
  181 LHGRYTCIAR KPRCGSCIIE DLCEYKEKVD I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..211] PSI-BLAST 70.0 REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.08559331236111 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  3.73234184319832 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.12421941323765 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.54759386266723 bayes_pls_golite062009
  • catalytic activity
    		•  2.50389926428623 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  1.80199518353554 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.75218522602775 bayes_pls_golite062009
  • hydrolase activity
    		•  1.39000450534744 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.14337995879633 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  0.473206156100251 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.29478804124408 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  0.253198605718519 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle