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Protein Overview: EG10980

General Information:
Name(s) found: sucB / EG10980 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • dihydrolipoyltranssuccinase / 2-oxoglutarate dehydrogenase, E2 component; dihydrolipoamide succinyltransferase; acid-inducible; yields succinyl-CoA and CO(2); also knwon as alpha-ketoglutarate dehydrogenase [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 405 amino acids

    Gene Ontology:
    Cellular Component: oxoglutarate dehydrogenase complex [IDALink to PubMed article][IEA]
    Biological Process: tricarboxylic acid cycle [IEA][IMPLink to PubMed article]
    Molecular Function: dihydrolipoyllysine-residue succinyltransferase activity [IDALink to PubMed article][IEA][IMPLink to PubMed article]
    lipoic acid binding [IDALink to PubMed article][IEA]
    protein binding [IDALink to PubMed article][IEA][IPILink to PubMed articleLink to PubMed article]
    binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVDILVPD LPESVADATV ATWHKKPGDA VVRDEVLVEI ETDKVVLEVP ASADGILDAV  60
   61 LEDEGTTVTS RQILGRLREG NSAGKETSAK SEEKASTPAQ RQQASLEEQN NDALSPAIRR 120
  121 LLAEHNLDAS AIKGTGVGGR LTREDVEKHL AKAPAKESAP AAAAPAAQPA LAARSEKRVP 180
  181 MTRLRKRVAE RLLEAKNSTA MLTTFNEVNM KPIMDLRKQY GEAFEKRHGI RLGFMSFYVK 240
  241 AVVEALKRYP EVNASIDGDD VVYHNYFDVS MAVSTPRGLV TPVLRDVDTL GMADIEKKIK 300
  301 ELAVKGRDGK LTVEDLTGGN FTITNGGVFG SLMSTPIINP PQSAILGMHA IKDRPMAVNG 360
  361 QVEILPMMYL ALSYDHRLID GRESVGFLVT IKELLEDPTR LLLDV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] PSI-BLAST 15.39794 LIPOYL DOMAIN FROM THE DIHYDROLIPOYL SUCCINYLTRANSFERASE COMPONENT OF THE 2-OXOGLUTARATE DEHYDROGENASE MULTIENZYME COMPLEX OF ESCHERICHIA COLI, NMR, 25 STRUCTURES
    2 View Details [93..159] PSI-BLAST 4.0 Solution structure of the e3_binding domain of dihydrolipoamide branched chaintransacylase
    3 View Details [160..405] PSI-BLAST 91.0 Dihydrolipoamide succinyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  7.74877411346968 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  7.59642806209362 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  7.45508609960612 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  7.05950875585975 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  5.24395351180663 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.55333192628786 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  3.31123635155865 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  2.83081843426182 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  2.82233689048595 bayes_pls_golite062009
  • acyltransferase activity
    		•  2.79754636323803 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  2.53708026587542 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.22092493760605 bayes_pls_golite062009
  • catalytic activity
    		•  1.39099902011318 bayes_pls_golite062009
  • binding
    		•  0.988780943163898 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.629490807878017 bayes_pls_golite062009
  • ligase activity
    		•  0.56894584941056 bayes_pls_golite062009
  • aminomethyltransferase activity
    		•  0.377624262164477 bayes_pls_golite062009
  • protein binding
    		•  0.273657523907432 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  0.0222922933292004 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  0.0222922933292004 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • S-succinyltransferase activity
    		•  10.0778678835755 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  10.0778678835755 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  9.65061123545754 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  9.64995677986911 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  9.49696044977584 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  8.45313874919036 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  8.17557182322815 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  6.86215901871647 bayes_pls_golite062009
  • acyltransferase activity
    		•  6.83977352892719 bayes_pls_golite062009
  • succinyltransferase activity
    		•  6.58826720904067 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.40483178382327 bayes_pls_golite062009
  • acetyltransferase activity
    		•  6.08159176722072 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.93985773477717 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.60481199262496 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  4.42757758312016 bayes_pls_golite062009
  • carnitine O-acyltransferase activity
    		•  2.87366177129153 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.54513901872655 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  1.33852311685118 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • transferase activity
    		•  1.08341671157927 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  1.00868366840715 bayes_pls_golite062009
  • binding
    		•  0.801074244553007 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  0.54660034926676 bayes_pls_golite062009
  • protein binding
    		•  0.00454070917775817 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle