YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: EG10530

General Information:
Name(s) found: lepB / EG10530 [EcoGene]
Description(s) found:
Found 4 descriptions.
SHOW ALL
  • leader peptidase (signal peptidase I) / Signal peptidase I; SPI; responsible for type I signal cleavages of periplasmic, OM, some IM, and extracellular proteins [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 324 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDALink to PubMed article][IEA]
    plasma membrane [IDALink to PubMed article][IEA]
    Biological Process: proteolysis [IDALink to PubMed article][IEA][IMPLink to PubMed article]
    protein processing [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: toxin binding [IMPLink to PubMed article]
    serine-type peptidase activity [IEA]
    peptidase activity [IDALink to PubMed article][IEA][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANMFALILV IATLVTGILW CVDKFFFAPK RRERQAAAQA AAGDSLDKAT LKKVAPKPGW  60
   61 LETGASVFPV LAIVLIVRSF IYEPFQIPSG SMMPTLLIGD FILVEKFAYG IKDPIYQKTL 120
  121 IETGHPKRGD IVVFKYPEDP KLDYIKRAVG LPGDKVTYDP VSKELTIQPG CSSGQACENA 180
  181 LPVTYSNVEP SDFVQTFSRR NGGEATSGFF EVPKNETKEN GIRLSERKET LGDVTHRILT 240
  241 VPIAQDQVGM YYQQPGQQLA TWIVPPGQYF MMGDNRDNSA DSRYWGFVPE ANLVGRATAI 300
  301 WMSFDKQEGE WPTGLRLSRI GGIH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..324] PSI-BLAST 65.09691 Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  0.485843348899278 bayes_pls_golite062009
  • catalytic activity
    		•  0.415601732277814 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.237734983138449 bayes_pls_golite062009
  • hydrolase activity
    		•  0.188292586303013 bayes_pls_golite062009
  • protein binding
    		•  0.0579980138351139 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle