Protein Overview: phl-PB

General Information:
Name(s) found:	phl-PB / FBpp0110324 [FlyBase]
Description(s) found: Found 14 descriptions. SHOW ALL	The gene pole hole is referred to in FlyBase by the symbol Dmel\phl (CG2845, FBgn0003079). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2227994..2237904. It has the cytological map location 3A1. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; organ morphogenesis; regulation of biological process; hemocyte differentiation; reproductive process in a multicellular organism; instar larval development; regulation of neurogenesis; establishment or maintenance of polarity of follicular epithelium; embryonic morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; cellular component movement; regulation of developmental process; regulation of multicellular organism growth. 83 alleles are reported. The phenotypes of these alleles are annotated with 59 unique terms, many of which group under: external compound sense organ; adult segment; peripheral nervous system; organ system; adult mesothoracic segment; nervous system; embryonic abdomen; embryonic segment; hemocyte; embryonic/larval hemocoel; spermatocyte. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	782 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	regulation of multicellular organism growth [IMP] wing disc morphogenesis [IMP] epidermal growth factor receptor signaling pathway [IGI] hemopoiesis [TAS] imaginal disc-derived wing morphogenesis [IMP] positive regulation of photoreceptor cell differentiation [IMP] hemocyte differentiation [IGI][IMP] dorsal/ventral axis specification, ovarian follicular epithelium [IMP] border follicle cell migration [IGI] lamellocyte differentiation [IMP][TAS] protein amino acid phosphorylation [IEA] gastrulation [IMP] instar larval development [IMP] primary branching, open tracheal system [TAS] intracellular signaling pathway [IEA] wing and notum subfield formation [IGI]
Molecular Function:	ATP binding [IEA] protein tyrosine kinase activity [IEA] protein binding [IPI] receptor signaling protein activity [IEA] protein serine/threonine kinase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSESSTEGD SDLYDPLAEE LHNVQLVKHV TRENIDALNA KFANLQEPPA MYLIGESSKA  60
   61 ELNTTWVLGN PTPTSKLFIK YPTYVYVCIS RLWFLPTEYQ ELTSKLHELE AKEQELMERL 120
  121 NSQDQQEDSS LVERFKEQPH YQNQTQILQQ QRQLARVHHG NDLTDSLGSQ PGSQCGTLTR 180
  181 QPKILLRAHL PNQQRTSVEV ISGVRLCDAL MKALKLRQLT PDMCEVSTTH SGRHIIPWHT 240
  241 DIGTLHVEEI FVRLLDKFPI RTHIKHQIIR KTFFSLVFCE GCRRLLFTGF YCSQCNFRFH 300
  301 QRCANRVPML CQPFPMDSYY QLLLAENPDN GVGFPGRGTA VRFNMSSRSR SRRCSSSGSS 360
  361 SSSKPPSSSS GNHRQGRPPR ISQDDRSNSA PNVCINNIRS VTSEVQRSLI MQARPPLPHP 420
  421 CTDHSNSTQA SPTSTLKHNR PRARSADESN KNLLLRDAKS SEENWNILAE EILIGPRIGS 480
  481 GSFGTVYRAH WHGPVAVKTL NVKTPSPAQL QAFKNEVAML KKTRHCNILL FMGCVSKPSL 540
  541 AIVTQWCEGS SLYKHVHVSE TKFKLNTLID IGRQVAQGMD YLHAKNIIHR DLKSNNIFLH 600
  601 EDLSVKIGDF GLATAKTRWS GEKQANQPTG SILWMAPEVI RMQELNPYSF QSDVYAFGIV 660
  661 MYELLAECLP YGHISNKDQI LFMVGRGLLR PDMSQVRSDA PQALKRLAED CIKYTPKDRP 720
  721 LFRPLLNMLE NMLRTLPKIH RSASEPNLTQ SQLQNDEFLY LPSPKTPVNF NNFQFFGSAG 780
  781 NI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
epidermal growth factor receptor binding	2.9751846707539	bayes_pls_golite062009
binding	2.79128751898373	bayes_pls_golite062009
insulin receptor binding	2.73485644242393	bayes_pls_golite062009
GTPase regulator activity	2.70614727793157	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.68579854252375	bayes_pls_golite062009
protein binding	2.34145982999922	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.10625597744594	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	2.06038764955701	bayes_pls_golite062009
kinase activity	2.03632850156074	bayes_pls_golite062009
enzyme regulator activity	1.9750017471254	bayes_pls_golite062009
small GTPase regulator activity	1.95738547986197	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.8531437045627	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.76952905409847	bayes_pls_golite062009
protein kinase activity	1.62921423829738	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
receptor binding	1.52843393025918	bayes_pls_golite062009
transferase activity	1.4550521488922	bayes_pls_golite062009
signal transducer activity	1.25507073225414	bayes_pls_golite062009
molecular transducer activity	1.25507073225414	bayes_pls_golite062009
Ras GTPase activator activity	1.09070479183477	bayes_pls_golite062009
transcription regulator activity	1.08577758274384	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	0.958295643211986	bayes_pls_golite062009
protein serine/threonine kinase activity	0.956859696337723	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
GTPase activator activity	0.717730683557543	bayes_pls_golite062009
protein complex binding	0.65988681496356	bayes_pls_golite062009
protein phosphorylated amino acid binding	0.649814096718101	bayes_pls_golite062009
nucleic acid binding	0.604021689968387	bayes_pls_golite062009
DNA binding	0.418154636457321	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
enzyme activator activity	0.298334474872045	bayes_pls_golite062009
protein tyrosine kinase activity	0.206747304356052	bayes_pls_golite062009
catalytic activity	0.194464246602439	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.169458153875562	bayes_pls_golite062009
phosphoprotein binding	0.16798254471727	bayes_pls_golite062009
cytokine receptor binding	0.16478124520484	bayes_pls_golite062009
kinase regulator activity	0.10704587503284	bayes_pls_golite062009
receptor signaling protein activity	0.0443241110585009	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..367]	PSI-BLAST	17.0	Crystal Structure of the Human Beta2-Chimaerin
2	View Details	[368..449]	deduced	N/A	No confident structure predictions are available.
3	View Details	[450..782]	PSI-BLAST	68.30103	No description for 2fb8A was found.

Protein Overview: phl-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: