Protein Overview: gi|16215719

General Information:
Name(s) found:	gi\|16215719 [NCBI NR]
Description(s) found: SHOW ONLY BEST	gi\|16215719\|dbj\|BAB69959.1\| double-strand-specific ribonuclease [Drosophila melanogaster] [NCBI NR] double-strand-specific ribonuclease [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] Double-strand-specific ribonuclease OS=Drosophila melanogaster GN=Dcr-2 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
Organism:	Drosophila melanogaster
Length:	1722 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	siRNA loading onto RISC involved in RNA interference [IMP] defense response to virus [IMP] chromatin silencing [IMP] production of siRNA involved in RNA interference [IDA][IMP][TAS] RNA interference [IDA][IMP][NAS][TAS] dsRNA transport [IMP] targeting of mRNA for destruction involved in RNA interference [IMP]
Molecular Function:	ATP binding [IEA] ribonuclease III activity [IEA] double-stranded RNA binding [IEA][ISS][NAS] ATP-dependent helicase activity [IEA] helicase activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDVEIKPRG YQLRLVDHLT KSNGIVYLPT GSGKTFVAIL VLKRFSQDFD KPIESGGKRA  60
   61 LFMCNTVELA RQQAMAVRRC TNFKVGFYVG EQGVDDWTRG MWSDEIKKNQ VLVGTAQVFL 120
  121 DMVTQTYVAL SSLGVVIIDE CHHGTGHHPF REFMRLFTIA NQTKLPRVVG LTGVLIKGNE 180
  181 ITNVATKLKE LEITYRGNII TVSDTKEMEN VMLYATKPTE VLVSFPHQEQ VLTVTRLISA 240
  241 EIEKFYVSLD LMNFGVQPIR RSKSLQCLRD PSKKSFVKQL FNDFLYQMKE YGIYAASIAI 300
  301 ISLIVEFDIK RRQAETLSVK LMHRTALTLC EKIRHLLVQK LQDMTYDDDD DNVNTEEVIM 360
  361 NFSTPKVQRF LMSLKVSFAD KDPKDICCLV FVERRYTCKC IYGLLLNYIQ STPELRNVLT 420
  421 PQFMVGRNNI SPDFESVLER KWQKSAIQQF RDGNANLMIC SSVLEEGIDV QACNHVFILD 480
  481 PVKTFNMYVQ SKGRARTTEA KFVLFTADKE REKTIQQIYQ YRKAHNDIAE YLKDRVLEKT 540
  541 EPELYEIKGH FQDDIDPFTN ENGAVLLPNN ALAILHRYCQ TIPTDAFGFV IPWFHVLQED 600
  601 ERDRIFGVSA KGKHVISINM PVNCMLRDTI YSDPMDNVKT AKISAAFKAC KVLYSLGELN 660
  661 ERFVPKTLKE RVASIADVHF EHWNKYGDSV TATVNKADKS KDRTYKTECP LEFYDALPRV 720
  721 GEICYAYEIF LEPQFESCEY TEHMYLNLQT PRNYAILLRN KLPRLAEMPL FSNQGKLHVR 780
  781 VANAPLEVII QNSEQLELLH QFHGMVFRDI LKIWHPFFVL DRRSKENSYL VVPLILGAGE 840
  841 QKCFDWELMT NFRRLPQSHG SNVQQREQQP APRPEDFEGK IVTQWYANYD KPMLVTKVHR 900
  901 ELTPLSYMEK NQQDKTYYEF TMSKYGNRIG DVVHKDKFMI EVRDLTEQLT FYVHNRGKFN 960
  961 AKSKAKMKVI LIPELCFNFN FPGDLWLKLI FLPSILNRMY FLLHAEALRK RFNTYLNLHL1020
 1021 LPFNGTDYMP RPLEIDYSLK RNVDPLGNVI PTEDIEEPKS LLEPMPTKSI EASVANLEIT1080
 1081 EFENPWQKYM EPVDLSRNLL STYPVELDYY YHFSVGNVCE MNEMDFEDKE YWAKNQFHMP1140
 1141 TGNIYGNRTP AKTNANVPAL MPSKPTVRGK VKPLLILQKT VSKEHITPAE QGEFLAAITA1200
 1201 SSAADVFDME RLEILGDSFL KLSATLYLAS KYSDWNEGTL TEVKSKLVSN RNLLFCLIDA1260
 1261 DIPKTLNTIQ FTPRYTWLPP GISLPHNVLA LWQENPEFAK IIGPHNLRDL ALGDEESLVK1320
 1321 GNCSDINYNR FVEGCRANGQ SFYAGADFSS EVNFCVGLVT ILNKVIADTL EALLGVIVKN1380
 1381 YGLQHAFKML EYFKICRADI DKPLTQLLNL ELGGKKMRAN VNTTEIDGFL INHYYLEKNL1440
 1441 GYTFKDRRYL LQALTHPSYP TNRITGSYQE LEFIGDAILD FLISAYIFEN NTKMNPGALT1500
 1501 DLRSALVNNT TLACICVRHR LHFFILAENA KLSEIISKFV NFQESQGHRV TNYVRILLEE1560
 1561 ADVQPTPPDL DDELDMTELP HANKCISQEA EKGVPPKGEF SMSTNVDVPK ALGDVLEALI1620
 1621 AAVYLDCRDL QRTWEVIFNL FEPELQEFTR KVPINHIRQL VEHKHAKPVF GSPIVEGGTV1680
 1681 MVSCQFTCME KTIKVYGFGS NKDQAKLSAA KHALQQLSKC DA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Protein Overview: gi|16215719

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: