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View Structure Prediction Details

Protein: lola-PK
Organism: Drosophila melanogaster
Length: 546 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lola-PK.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
642.0 [0..48] [546..2388]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL  60
   61 LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
  121 GGGVAPKPES SGHHRGGK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.522879
Match: 2ihcA
Description: No description for 2ihcA was found.

Predicted Domain #2
Region A:
Residues: [139-229]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSGAYTLEQT KRARLATGGA MDTSGDVSGS REGSSSPSRR RRKVRRRSME NDAHDNSNSS  60
   61 VLQAAASNQS ILQQTGAGLA VSALVTTQLS S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [230-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPAAGTSSQA SSTQQQQPLT STNVTKKTES AKLTSSTAAP ASGASASAAV QQAHLHQQQA  60
   61 QTTSDAINTE NVQAQSQGGA QGVQGDDEDI DEGSAVGGPN SATGPNPASA SASAVHAGVV 120
  121 VKQLASVVDK SSSNHKHKIK DNSVSSVGSE MVIEPKAEYD DDAHDENVED LTLDEEDMTM 180
  181 EELDQTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [417-546]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTSQGGEGSS QTYATWQHDR SQDELGLMAQ DAQQRDPQDF VLTWYQHACD QCGKSYKTRK  60
   61 SLSRHRRFEC RFTTERPIFQ CPSCNYAAKR SDNLTKHIKT HFAKMKKDFL PLAFQMQAST 120
  121 GIATKWEATA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 1a1fA
Description: ZIF268
Matching Structure (courtesy of the PDB):

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