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View Structure Prediction Details

Protein: gi|45446662, gi|...
Organism: Drosophila melanogaster
Length: 1031 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|45446662, gi|....

Description E-value Query
Range
Subject
Range
LpR1-PH - The gene LpR1 is referred to in FlyBase by the symbol Dmel\LpR1 (CG31094, FBgn0066101). It is a prot...
704.0 [0..1] [1031..1]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIESRSTST ASETTKTAIK STTSSKSPVT FGNLGEKRRA EQLFRCACAN FNLLLLTLML  60
   61 GFGKCCTATP TPLNTPSTNT PTSAVSPHNP QTLDESGSLS KVIDGKAFIN MGFKFLNVSG 120
  121 KIGTPLGIGQ SLEAKCDEKQ FQCHSGDCIP IRFVCDGDAD CKDHSDEQIK E

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.52
Match: 2gtlO
Description: No description for 2gtlO was found.

Predicted Domain #2
Region A:
Residues: [172-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CKFIEATCSS DQFRCGNGNC IPNKWRCDQE SDCADGSDEA NELCRARTCS PDEYACKSGE  60
   61 GQCVPLAWMC DQSKDCSDGS DEHNCNQTCR ADEFTCGNGR CIQKRWKCDH DDDCGDGSDE 120
  121 KECPVVPCDS VAEHTCTNGA CIAKRWVCDG DPDCSDGSDE RSCANVTKTT TPCLSHEYQC 180
  181 KDRITCLHHS WLCDGDRDCP DGDDEHTANC KNVTCRADQF QCGDRSCIPG HLTCNGDKDC 240
  241 ADGSDERDCG LSLSLGINQG GCNATSEFDC GGGQCVPLSK VCDKRKDCPD GEDEPAGKCG 300
  301 INECASKNGG CMHQCIDLKV GHHCECHEGY KLSPDKRNCQ DINECEVPGK CSQICVNEIG 360
  361 GFKCECEAGY MRDPKNHTRC KASEGHASLL LARRHDIRKI ALDHMEMTSI VNSTKAATAL 420
  421 DFVFRTGMIF WSDVTTQSIY KAPIDEGNEK TVVLTKSSVT SDGLAVDWIY NHVYFTDTHK 480
  481 CTIELTNFEG SMGKVLVKDS LDIPRSIALD PIEGWMYWSD WGASPRIERA GMDGSHRTTI 540
  541 ISYDVKWPNG ITLDLVKKRI YWVDGKLNVI SSANYDGSQR SQVLYSGEYL RHPFSITTFE 600
  601 DNVYWTDWDK QAVFKANKFT GEDVEPVTAM HMLQHPMVVH VYHPYRQPDG VNHCQSVNGH 660
  661 CSHLCLPAPR INERSPRISC ACPTGLKLMV DGLMCVEDLT RPPRARKTKP RPKSPRRRLP 720
  721 TGVQVGHADI RIEINDDLQL STRLPLLPTT FVADQRPVKN HTQIEKTTTP SEQPD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 129.0
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
very-low-density lipoprotein receptor activity 7.75680908341624 bayes_pls_golite062009
very-low-density lipoprotein binding 7.75680908341624 bayes_pls_golite062009
low-density lipoprotein binding 6.26591728596226 bayes_pls_golite062009
receptor activity 5.18957329214193 bayes_pls_golite062009
transmembrane receptor activity 5.12821337870369 bayes_pls_golite062009
molecular transducer activity 4.28859337937742 bayes_pls_golite062009
signal transducer activity 4.28859337937742 bayes_pls_golite062009
lipoprotein binding 4.14588039269064 bayes_pls_golite062009
ErbB-2 class receptor binding 4.1172010378646 bayes_pls_golite062009
low-density lipoprotein receptor activity 3.65371958920557 bayes_pls_golite062009
lipoprotein receptor binding 3.5371428063122 bayes_pls_golite062009
ErbB-3 class receptor binding 3.52219710022937 bayes_pls_golite062009
lipoprotein receptor activity 3.27342368855237 bayes_pls_golite062009
apolipoprotein binding 3.15697162337516 bayes_pls_golite062009
binding 3.10919144943954 bayes_pls_golite062009
glycosaminoglycan binding 2.86713236325679 bayes_pls_golite062009
heparin binding 2.49012176521764 bayes_pls_golite062009
polysaccharide binding 2.16901652361989 bayes_pls_golite062009
transcription regulator activity 2.16844098063599 bayes_pls_golite062009
sterol transporter activity 2.16184949636569 bayes_pls_golite062009
apolipoprotein E binding 2.15688766106363 bayes_pls_golite062009
protein binding 2.11668700345827 bayes_pls_golite062009
receptor binding 2.00382722979859 bayes_pls_golite062009
lipid transporter activity 1.91872326766441 bayes_pls_golite062009
lipoprotein transporter activity 1.72944996169507 bayes_pls_golite062009
transcription factor binding 1.71838409809333 bayes_pls_golite062009
transcription cofactor activity 1.61057978332614 bayes_pls_golite062009
high-density lipoprotein binding 1.52515316728946 bayes_pls_golite062009
growth factor activity 1.52153421000803 bayes_pls_golite062009
transporter activity 1.44005597324471 bayes_pls_golite062009
collagen binding 1.3611207932336 bayes_pls_golite062009
protein transporter activity 1.27232657510644 bayes_pls_golite062009
pattern binding 1.26957983931218 bayes_pls_golite062009
substrate-specific transporter activity 1.08803800589535 bayes_pls_golite062009
protein kinase activity 1.00235965838736 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.741912411452008 bayes_pls_golite062009
carbohydrate binding 0.72748768329894 bayes_pls_golite062009
kinase activity 0.692244195382463 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.67022333774569 bayes_pls_golite062009
extracellular matrix structural constituent 0.66981956037474 bayes_pls_golite062009
cell adhesion molecule binding 0.44857826904729 bayes_pls_golite062009
extracellular matrix binding 0.3265100728106 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [947-1031]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGFIALVVIA SLSGFAVLLS VLLLIGYRYC SKRRINSMNF ENPIYRKTTT TEDHFSLRKN  60
   61 LPARIYDHTS VMDEEYSPVI GISSY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle