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View Structure Prediction Details

Protein: Taf1-PB
Organism: Drosophila melanogaster
Length: 2129 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Taf1-PB.

Description E-value Query
Range		 Subject
Range
Taf1-PC - The gene TBP-associated factor 1 is referred to in FlyBase by the symbol Dmel\Taf1 (CG17603, FBgn001...
 1979.0 [0..1] [2129..1]

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Predicted Domain #1
Region A:
Residues: [1-135] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMESDNSDD EGSIGNGLDL TGILFGNIDS EGRLLQDDDG EGRGGTGFDA ELRENIGSLS  60
   61 KLGLDSMLLE VIDLKEAEPP SDDEEEEDAR PSAVSASEGM SAFDALKAGV KREDGAVKAQ 120
  121 DDAIDYSDIT ELSED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.09691
Match: 1tbaA
Description: TAF(II)230 TBP-binding fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [136-188] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPRTPPEETS TYDDLEDAIP ASKVEAKLTK DDKELMPPPS APMRSGSGGG IEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [189-389] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAKSNDASSP SDDSKSTDSK DADRKLDTPL ADILPSKYQN VDVRELFPDF RPQKVLRFSR  60
   61 LFGPGKPTSL PQIWRHVRKR RRKRNQSRDQ KTTNTGGSDS PSDTEEPRKR GFSLHYAAEP 120
  121 TPAECMSDDE DKLLGDFNSE DVRPEGPDNG ENSDQKPKVA DWRFGPAQIW YDMLEVPDSG 180
  181 EGFNYGFKTK AASTSSQPQL K

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [390-470] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DERRVKSPED DVEDPSIADD AFLMVSQLHW EDDVVWDGND IKAKVLQKLN SKTNAAGWLP  60
   61 SSGSRTAGAF SQPGKPSMPV G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [471-534] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSSKQGSGA SSKKAQQNAQ AKPAEAPDDT WYSLFPVENE ELIYYKWEDE VIWDAQQVSK  60
   61 VPKP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [535-622] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVLTLDPNDE NIILGIPDDI DPSKINKSTG PPPKIKIPHP HVKKSKILLG KAGVINVLAE  60
   61 DTPPPPPKSP DRDPFNISND TYYTPKTE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [623-880] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTLRLKVGGN LIQHSTPVVE LRAPFVPTHM GPMKLRAFHR PPLKKYSHGP MAQSIPHPVF  60
   61 PLLKTIAKKA KQREVERIAS GGGDVFFMRN PEDLSGRDGD IVLAEFCEEH PPLINQVGMC 120
  121 SKIKNYYKRK AEKDSGPQDF VYGEVAFAHT SPFLGILHPG QCIQAIENNM YRAPIYPHKM 180
  181 AHNDFLVIRT RNNYWIRSVN SIYTVGQECP LYEVPGPNSK RANNFTRDFL QVFIYRLFWK 240
  241 SRDNPRRIRM DDIKQAFP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [881-1336] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AHSESSIRKR LKQCADFKRT GMDSNWWVIK PEFRLPSEEE IRAMVSPEQC CAYFSMIAAE  60
   61 QRLKDAGYGE KFLFAPQEDD DEEAQLKLDD EVKVAPWNTT RAYIQAMRGK CLLQLSGPAD 120
  121 PTGCGEGFSY VRVPNKPTQT KEEQESQPKR SVTGTDADLR RLPLQRAKEL LRQFKVPEEE 180
  181 IKKLSRWEVI DVVRTLSTEK AKAGEEGMDK FSRGNRFSIA EHQERYKEEC QRIFDLQNRV 240
  241 LASSEVLSTD EAESSASEES DLEELGKNLE NMLSNKKTST QLSREREELE RQELLRQLDE 300
  301 EHGGPSGSGG AKGAKGKDDP GQQMLATNNQ GRILRITRTF RGNDGKEYTR VETVRRQPVI 360
  361 DAYIKIRTTK DEQFIKQFAT LDEQQKEEMK REKRRIQEQL RRIKRNQERE RLAQLAQNQK 420
  421 LQPGGMPTSL GDPKSSGGHS HKERDSGYKE VSPSRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1hciA
Description: alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.1249176514747 bayes_pls_golite062009
protein binding 3.02658853804606 bayes_pls_golite062009
binding 3.02588173330447 bayes_pls_golite062009
actin binding 2.99249761866244 bayes_pls_golite062009
actin filament binding 2.67692481578399 bayes_pls_golite062009
transcription regulator activity 2.44577095508006 bayes_pls_golite062009
transcription activator activity 2.01637187744715 bayes_pls_golite062009
protein complex binding 1.83007463428411 bayes_pls_golite062009
transcription coactivator activity 1.17938200837598 bayes_pls_golite062009
protein dimerization activity 0.909550969508159 bayes_pls_golite062009
identical protein binding 0.650360032617391 bayes_pls_golite062009
structural molecule activity 0.565745818602161 bayes_pls_golite062009
transcription factor binding 0.563443610763849 bayes_pls_golite062009
receptor binding 0.344679796081435 bayes_pls_golite062009
transcription cofactor activity 0.32199002401243 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1337-1400] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFKLKPDLKL KCGACGQVGH MRTNKACPLY SGMQSSLSQS NPSLADDFDE QSEKEMTMDD  60
   61 DDLV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1401-1724] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVDGTKVTLS SKILKRHGGD DGKRRSGSSS GFTLKVPRDA MGKKKRRVGG DLHCDYLQRH  60
   61 NKTANRRRTD PVVVLSSILE IIHNELRSMP DVSPFLFPVS AKKVPDYYRV VTKPMDLQTM 120
  121 REYIRQRRYT SREMFLEDLK QIVDNSLIYN GPQSAYTLAA QRMFSSCFEL LAEREDKLMR 180
  181 LEKAINPLLD DDDQVALSFI FDKLHSQIKQ LPESWPFLKP VNKKQVKDYY TVIKRPMDLE 240
  241 TIGKNIEAHR YHSRAEYLAD IELIATNCEQ YNGSDTRYTK FSKKILEYAQ TQLIEFSEHC 300
  301 GQLENNIAKT QERARENAPE FDEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.045757
Match: 1eqfA
Description: TAFII250 double bromodomain module
Matching Structure (courtesy of the PDB):

Predicted Domain #11
Region A:
Residues: [1725-1814] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WGNDDYNFDR GSRASSPGDD YIDVEGHGGH ASSSNSIHRS MGAEAGSSHT APAVRKPAPP  60
   61 GPGEVKRGRG RPRKQRDPVE EVKSQNPVKR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1815-2016] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRGRPRKDSL ASNMSHTQAY FLDEDLQCST DDEDDDEEED FQEVSEDENN AASILDQGER  60
   61 INAPADAMDG MFDPKNIKTE IDLEAHQMAE EPIGEDDSQQ VAEAMVQLSG VGGYYAQQQQ 120
  121 DESMDVDPNY DPSDFLAMHK QRQSLGEPSS LQGAFTNFLS HEQDDNGPYN PAEASTSAAS 180
  181 GADLGMDASM AMQMAPEMPV NT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [2017-2129] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNGMGIDDD LDISESDEED DGSRVRIKKE VFDDGDYALQ HQQMGQAASQ SQIYMVDSSN  60
   61 EPTTLDYQQP PQLDFQQVQE MEQLQHQVMP PMQSEQLQQQ QTPQGDNDYA WTF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

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Created and Maintained by: Michael Riffle