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View Structure Prediction Details

Protein: gi|7511903, gi|4...
Organism: Drosophila melanogaster
Length: 665 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7511903, gi|4....

Description E-value Query
Range
Subject
Range
gi|24639248, gi|... - gi|24639248|ref|NP_726786.1| CG4199, isoform E [Drosophila melanogaster], gi|22831547|gb|AAN09069.1|...
442.0 [0..22] [665..4]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDWPFCLSV SKVGGLQIRK KWQSPRTALS LVKTKRAFEG LLRIRKLPSS QSWRILNAPS  60
   61 FASHINNRLL NTMGSVNCKE YKTTGSTPKK EKSTGGAVGS YQSKCSNQSP STTMSTEESS 120
  121 PDSE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.965
Match: 1iarB
Description: Interleukin-4 receptor alpha chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.07386271831775 bayes_pls_golite062009
binding 3.01297199434173 bayes_pls_golite062009
receptor activity 1.99923068102422 bayes_pls_golite062009
transmembrane receptor activity 1.94373624851094 bayes_pls_golite062009
molecular transducer activity 1.74126968021358 bayes_pls_golite062009
signal transducer activity 1.74126968021358 bayes_pls_golite062009
cytokine binding 1.17392704995902 bayes_pls_golite062009
growth factor binding 1.05300782116518 bayes_pls_golite062009
cytokine receptor activity 0.77377640884237 bayes_pls_golite062009
receptor binding 0.73866004523665 bayes_pls_golite062009
protein dimerization activity 0.674567146312744 bayes_pls_golite062009
protease binding 0.488597231764147 bayes_pls_golite062009
transcription regulator activity 0.48635527300904 bayes_pls_golite062009
enzyme binding 0.473046788409936 bayes_pls_golite062009
transcription activator activity 0.473002127561165 bayes_pls_golite062009
nucleic acid binding 0.408798856629207 bayes_pls_golite062009
identical protein binding 0.368517091723107 bayes_pls_golite062009
DNA binding 0.319941421296035 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [125-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTSAVPVDCR VTDLKENEMK QVDFDEDTRV LLVKQNDRLL AVGAKCTHYG APLQTGALGL  60
   61 GRVRCPWHGA CFNLENGDIE DFPGLDSLPC YRVEVGNEGQ VMLRAKRSDL VNNKRLKNMV 120
  121 RRKPDDQRVF IVVGGGPSGA VAVETIRQEG FTGRLIFVCR EDYLPYDRVK ISKAMNLEIE 180
  181 QLRFRDEEFY KEYDIELWQG VAAEKLDTAQ KELHCSNGYV VKYDKIYLAT GCSAFRPPIP 240
  241 GVNLENVRTV RELADTKAIL ASITPESRVV CLGSSFIALE AAAGLVSKVQ SVTVVGRENV 300
  301 PLKAAFGAEI GQRVLQLFED NKVVMRMESG IAEIVGNEDG KVSEVVLVDD TRLPCDLLIL 360
  361 GTGSKLNTQF LAKSGVKVNR NGSVDVTDFL ESNVPDVYVG GDIANAHIHG LAHDRVNIGH 420
  421 YQLAQYHGRV AAINMCGGVK KLEAVPFFFT LIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1h7xA
Description: Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.37477730756688 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 3.17769237742078 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 2.66213649027918 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 1.91752931331276 bayes_pls_golite062009
binding 1.75241039340546 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 1.6431755180135 bayes_pls_golite062009
succinate dehydrogenase (ubiquinone) activity 1.56913317166386 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor 1.56913317166386 bayes_pls_golite062009
succinate dehydrogenase activity 1.54010881004951 bayes_pls_golite062009
protein binding 1.40812730845585 bayes_pls_golite062009
catalytic activity 1.35682608895635 bayes_pls_golite062009
thioredoxin-disulfide reductase activity 1.11021120187216 bayes_pls_golite062009
NADPH-adrenodoxin reductase activity 0.684108511779641 bayes_pls_golite062009
ion transmembrane transporter activity 0.230666982979064 bayes_pls_golite062009
cation transmembrane transporter activity 0.150449425695127 bayes_pls_golite062009
oxidoreductase activity 0.0180498293464497 bayes_pls_golite062009
disulfide oxidoreductase activity 0.0160065137614933 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [578-665]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKGIRYAGHG SYKDVIIDGS MEDFKFVAYF INEADTVTAV ASCGRDPIVA QFAELISQGK  60
   61 CLGRGQIEDP ATREDWTKKL GQPLPQVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.154902
Match: 1q1rA
Description: Crystal Structure of Putidaredoxin Reductase from Pseudomonas putida
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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