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View Structure Prediction Details

Protein: EMX1_MOUSE
Organism: Mus musculus
Length: 257 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EMX1_MOUSE.

Description E-value Query
Range
Subject
Range
gi|109103362 - gi|109103362|ref|XP_001103417.1| PREDICTED: similar to empty spiracles homolog 1 [Macaca mulatta]
EMX1 - empty spiracles homeobox 1
gi|208966206 - gi|208966206|dbj|BAG73117.1| empty spiracles homeobox 1 [synthetic construct]
157.0 [0..1] [257..1]
gi|76628915 - gi|76628915|ref|XP_586475.2| PREDICTED: similar to empty spiracles homolog 1 [Bos taurus]
155.0 [0..1] [257..1]
gi|109473809, gi... - gi|109473809|ref|XP_001073769.1| PREDICTED: similar to empty spiracles homolog 1 [Rattus norvegicus]...
155.0 [0..1] [257..1]
gi|119620162, gi... - gi|94536800|ref|NP_004088.2| empty spiracles homolog 1 [Homo sapiens], gi|119620162|gb|EAW99756.1| e...
155.0 [0..1] [257..34]
gi|21902136 - gi|21902136|gb|AAM78420.1| Emx3 [Scyliorhinus canicula]
130.0 [0..1] [257..1]
gi|116294310 - gi|116294310|gb|AAP79287.2| hox 7 [Saccoglossus kowalevskii]
129.0 [0..7] [228..1]
gi|47228655 - gi|47228655|emb|CAG07387.1| unnamed protein product [Tetraodon nigroviridis]
127.0 [0..1] [228..1]
gi|4322076 - gi|4322076|gb|AAD15947.1| homeobox protein [Danio rerio]
126.0 [0..7] [234..1]
gi|1334651 - gi|1334651|emb|CAA30124.1| unnamed protein product [Xenopus laevis]
126.0 [0..159] [248..3]

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Predicted Domain #1
Region A:
Residues: [1-125]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQPAAKRGF TIESLVAKDG GTGGSPGSGG AGSHPLAVAA SEEPLRPTAL NYPHPSAAET  60
   61 AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA HQLGSSSLQP PHSFFSAQHR 120
  121 DPLHF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [126-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPWVLRNRFF GHRFQASDVP QDGLLLHGPF ARKPKRIRTA FSPSQLLRLE RAFEKNHYVV  60
   61 GAERKQLAGS LSLSETQVKV WFQNRRTKYK RQKLEEEGPE SEQKKKGSHH INRWRIATKQ 120
  121 ANGEDIDVTS ND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.30103
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.67711146264366 bayes_pls_golite062009
DNA binding 4.26679916438424 bayes_pls_golite062009
nucleic acid binding 4.10991419309805 bayes_pls_golite062009
transcription factor activity 3.74788993580019 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.16521751467289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.96364983538233 bayes_pls_golite062009
transcription repressor activity 1.79427849359671 bayes_pls_golite062009
transcription activator activity 1.6126228397074 bayes_pls_golite062009
transcription factor binding 1.32991027110041 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.9526286147364 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
chromatin binding 0.775421813815509 bayes_pls_golite062009
transcription cofactor activity 0.71989890364863 bayes_pls_golite062009
transcription corepressor activity 0.0615820877359203 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle