| Protein: | FOXK2 |
| Organism: | Homo sapiens |
| Length: | 660 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOXK2.
| Description | E-value | Query Range |
Subject Range |
|
|
3.0E-68 | [1..660] | [1..655] |
|
|
6.0E-68 | [35..660] | [187..809] |
|
|
1.0E-65 | [35..660] | [176..797] |
|
|
1.0E-61 | [6..660] | [188..847] |
|
|
8.0E-58 | [109..647] | [33..571] |
|
|
4.0E-51 | [141..660] | [673..1215] |
|
Region A: Residues: [1-241] |
1 11 21 31 41 51
| | | | | |
1 MAAAAAALSG AGTPPAGGGA GGGGAGGGGS PPGGWAVARL EGREFEYLMK KRSVTIGRNS 60
61 SQGSVDVSMG HSSFISRRHL EIFTPPGGGG HGGAAPELPP AQPRPDAGGD FYLRCLGKNG 120
121 VFVDGVFQRR GAPPLQLPRV CTFRFPSTNI KITFTALSSE KREKQEASES PVKAVQPHIS 180
181 PLTINIPDTM AHLISPLPSP TGTISAANSC PSSPRGAGSS GYKVGRVMPS DLNLMADNSQ 240
241 P
|
| Detection Method: |  |
| Confidence: | 2.05 |
| Match: | 1g3gA |
| Description: | Phosphotyrosine binding domain of Rad53 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 3.49130250684713 | bayes_pls_golite062009 |
| transcription regulator activity | 3.38780975952028 | bayes_pls_golite062009 |
| DNA binding | 3.17754626214699 | bayes_pls_golite062009 |
| nucleic acid binding | 3.1171915055278 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.41431149922235 | bayes_pls_golite062009 |
| protein binding | 2.20369144716037 | bayes_pls_golite062009 |
| transcription factor activity | 2.00503872581265 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.58636372907213 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, cytoplasmic mediator activity | 1.48263552027263 | bayes_pls_golite062009 |
| transcription activator activity | 1.45614128243985 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase signaling protein activity | 1.2840212954552 | bayes_pls_golite062009 |
| chromatin binding | 1.24734533820287 | bayes_pls_golite062009 |
| promoter binding | 1.19827477319554 | bayes_pls_golite062009 |
| transcription factor binding | 0.840886266060694 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | 0.829235284155381 | bayes_pls_golite062009 |
| receptor signaling protein activity | 0.196567610974905 | bayes_pls_golite062009 |
| transcription repressor activity | 0.0741267027726338 | bayes_pls_golite062009 |
|
Region A: Residues: [242-358] |
1 11 21 31 41 51
| | | | | |
1 ENEKEASGGD SPKDDSKPPY SYAQLIVQAI TMAPDKQLTL NGIYTHITKN YPYYRTADKG 60
61 WQNSIRHNLS LNRYFIKVPR SQEEPGKGSF WRIDPASESK LIEQAFRKRR PRGVPCF
|
| Detection Method: | |
| Confidence: | 18.221849 |
| Match: | 2c6yA |
| Description: | No description for 2c6yA was found. |
| Term | Confidence | Notes |
| transcription regulator activity | 5.55329976718261 | bayes_pls_golite062009 |
| DNA binding | 5.08959163553491 | bayes_pls_golite062009 |
| nucleic acid binding | 4.99681957904233 | bayes_pls_golite062009 |
| transcription factor activity | 4.33152142980289 | bayes_pls_golite062009 |
| binding | 3.52874320222492 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.60738445921725 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.48053910222825 | bayes_pls_golite062009 |
| transcription activator activity | 2.37668609508629 | bayes_pls_golite062009 |
| transcription repressor activity | 2.22485867684613 | bayes_pls_golite062009 |
| transcription factor binding | 0.85714789329232 | bayes_pls_golite062009 |
| protein binding | 0.753698599635855 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 0.66743181561551 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity, enhancer binding | 0.23177057841536 | bayes_pls_golite062009 |
|
Region A: Residues: [359-544] |
1 11 21 31 41 51
| | | | | |
1 RTPLGPLSSR SAPASPNHAG VLSAHSSGAQ TPESLSREGS PAPLEPEPGA AQPKLAVIQE 60
61 ARFAQSAPGS PLSSQPVLIT VQRQLPQAIK PVTYTVATPV TTSTSQPPVV QTVHVVHQIP 120
121 AVSVTSVAGL APANTYTVSG QAVVTPAAVL APPKAEAQEN GDHREVKVKV EPIPAIGHAT 180
181 LGTASR
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [545-660] |
1 11 21 31 41 51
| | | | | |
1 IIQTAQTTPV QTVTIVQQAP LGQHQLPIKT VTQNGTHVAS VPTAVHGQVN NAAASPLHML 60
61 ATHASASASL PTKRHNGDQP EQPELKRIKT EDGEGIVIAL SVDTPPAAVR EKGVQN
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.461 | 0.945 | RNA polymerase II transcription factor activity | a.4.1 | Homeodomain-like |
