YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|119609434, gi...
Organism:	Homo sapiens
Length:	436 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119609434, gi....

Description	E-value	Query Range	Subject Range
gi\|73965261 - gi\|73965261\|ref\|XP_862191.1\| PREDICTED: similar to proteasome 26S non-ATPase subunit 12 isoform 2 is...	5.0E-94	[1..436]	[1..436]
gi\|53136554, gi\|... - gi\|71897101\|ref\|NP_001025877.1\| proteasome 26S non-ATPase subunit 12 [Gallus gallus], gi\|53136554\|em...	7.0E-94	[1..436]	[16..456]
gi\|42415501, gi\|... - gi\|42415501\|ref\|NP_963872.1\| proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Danio reri...	1.0E-93	[1..436]	[16..456]
gi\|12857304 - gi\|12857304\|dbj\|BAB30969.1\| unnamed protein product [Mus musculus]	3.0E-93	[1..436]	[16..456]
gi\|54400716, gi\|... - gi\|54400716\|ref\|NP_001005875.1\| proteasome 26S non-ATPase subunit 12 [Rattus norvegicus], gi\|5373354...	5.0E-93	[1..436]	[16..456]
PSD12_BOVIN - 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus GN=PSMD12 PE=2 SV=3	6.0E-93	[1..436]	[16..456]
gi\|123985956, gi... - gi\|168275714\|dbj\|BAG10577.1\| 26S proteasome non-ATPase regulatory subunit 12 [synthetic construct], ... gi\|114670121 - gi\|114670121\|ref\|XP_511639.2\| PREDICTED: proteasome 26S non-ATPase subunit 12 [Pan troglodytes] gi\|109117036 - gi\|109117036\|ref\|XP_001116817.1\| PREDICTED: proteasome 26S non-ATPase subunit 12 isoform 2 [Macaca m... PSMD12 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	1.0E-92	[1..436]	[16..456]

Back

Predicted Domain #1

Region A:
Residues: [1-218]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKASDM VSTSRILVAV VKMCYEAKEW  60
   61 DLLNENIMLL SKRRSQLKQA VAKMVQQCCT YVEEITDLPI KLRLIDTLRM VTEGKIYVEI 120
  121 ERARLTKTLA TIKEQNGDVK EAASILQELQ VETYGSMEKK ERVEFILEQM RLCLAVKDYI 180
  181 RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.0
Match:	2fo7A
Description:	Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [219-314]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYLSICKHYR AIYDTPCIQA ESEKWQQALK SVVLYVILAP FDNEQSDLVH RISGDKKLEE  60
   61 IPKYKDLLKL FTTMELMRWS TLVEDYGMEL RKGSLE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.910	0.011	cytosol	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain

Predicted Domain #3

Region A:
Residues: [315-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPATDVFGST EEGEKRWKDL KNRVVEHNIR IMAKYYTRIT MKRMAQLLDL SVDESEAFLS  60
   61 NLVVNKTIFA KVDRLAGIIN FQRPKDPNNL LNDWSQKLNS LMSLVNKTTH LIAKEEMIHN 120
  121 LQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.69897
Match:	1ufmA
Description:	Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.50995556050336	bayes_pls_golite062009
nucleic acid binding	3.38144578566524	bayes_pls_golite062009
binding	3.33026160538031	bayes_pls_golite062009
DNA binding	3.30822066787723	bayes_pls_golite062009
transcription factor activity	2.60537570879007	bayes_pls_golite062009
hydrolase activity	2.30467124306022	bayes_pls_golite062009
structural constituent of ribosome	1.46680509390433	bayes_pls_golite062009
sequence-specific DNA binding	1.32971938164691	bayes_pls_golite062009
transcription activator activity	1.08566311616647	bayes_pls_golite062009
transcription repressor activity	0.95491822926452	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.845023110629115	bayes_pls_golite062009
protein binding	0.653872239015235	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.42135864069093	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.136726704233672	bayes_pls_golite062009
small conjugating protein ligase activity	0.118016217031359	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: