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View Structure Prediction Details

Protein: HOXB6
Organism: Homo sapiens
Length: 224 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOXB6.

Description E-value Query
Range
Subject
Range
gi|4322076 - gi|4322076|gb|AAD15947.1| homeobox protein [Danio rerio]
1.0E-35 [1..213] [1..214]
gi|109114187, gi... - gi|109114187|ref|XP_001088485.1| PREDICTED: similar to homeobox B6 isoform 3 [Macaca mulatta], gi|10...
5.0E-35 [1..224] [1..224]
gi|60654293 - gi|60654293|gb|AAX29839.1| homeobox B6 [synthetic construct]
8.0E-35 [1..224] [1..224]
HXB6_MOUSE - Homeobox protein Hox-B6 OS=Mus musculus GN=Hoxb6 PE=1 SV=2
gi|62656892, gi|... - gi|62656892|ref|XP_573182.1| PREDICTED: similar to Homeobox protein Hox-B6 (Hox-2.2) (MH-22A) [Rattu...
2.0E-34 [1..224] [1..224]
HOXB6 - homeobox B6
2.0E-34 [1..224] [1..224]
gi|148226630, gi... - gi|148226630|ref|NP_001090379.1| homeo box B6 [Xenopus laevis], gi|116063408|gb|AAI23271.1| Hoxb6 pr...
4.0E-34 [1..224] [1..223]
gi|73966244, gi|... - gi|73966244|ref|XP_864710.1| PREDICTED: similar to Homeobox protein Hox-B6 (Hox-2.2) (MH-22A) isofor...
2.0E-33 [1..224] [1..224]
gi|76644498, gi|... - gi|76644500|ref|XP_887495.1| PREDICTED: similar to Homeobox protein Hox-B6 (Hox-2.2) (MH-22A) isofor...
3.0E-33 [1..211] [1..213]

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Predicted Domain #1
Region A:
Residues: [1-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD KGFATSSYYP  60
   61 PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH PEPRKSDCAQ DKSVFGETEE 120
  121 QKCSTPVYPW MQRMNSCNS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [140-224]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSFGPSGRRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHALCLTERQ IKIWFQNRRM  60
   61 KWKKESKLLS ASQLSAEEEE EKQAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.0
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle