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View Structure Prediction Details

Protein: NFS1
Organism: Homo sapiens
Length: 457 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NFS1.

Description E-value Query
Range
Subject
Range
gi|14714866 - gi|14714866|gb|AAH10586.1| Nitrogen fixation gene 1 (S. cerevisiae) [Mus musculus]
0.0 [1..457] [9..459]
gi|76880449, gi|... - gi|76880449|ref|NP_445914.2| NFS1 nitrogen fixation 1 homolog [Rattus norvegicus], gi|75775189|gb|AA...
gi|226498044, gi... - gi|226498044|ref|NP_001142293.1| hypothetical protein LOC100274462 [Zea mays], gi|194708056|gb|ACF88...
0.0 [1..457] [9..459]
gi|24042327 - gi|24042327|gb|AAD09187.2| cysteine desulfurase [Homo sapiens]
0.0 [1..457] [1..457]
gi|114681701 - gi|114681701|ref|XP_001165456.1| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes]
8.0E-99 [1..457] [1..457]

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Predicted Domain #1
Region A:
Residues: [1-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLRAAWRRA AVAVTAAPGP KPAAPTRGLR LRVGDRAPQS AVPADTAAAP EVGPVLRPLY  60
   61 MDVQATTPLD PRVLDAMLPY LINYYGNPHS RTHAYGWESE AAMERARQQV ASLIGADPRE 120
  121 IIFTSGATES NNIAIKGVAR FYRSRKKHLI TTQTEHKCVL DSCRSLEAEG FQVTYLPVQK 180
  181 SGIIDLKELE AAIQPDTSLV SVMTVNNEIG VKQPIAEIGR ICSSRKVYFH TDAAQAVGKI 240
  241 PLDVNDMKID LMSISGHKIY GPKGVGAIYI RRRPRVRVEA LQSGGGQERG MRSGTVPTPL 300
  301 VVGLGAACEV AQQEMEYDHK RISKLSERLI QNIMKSLPDV VMNGDPKHHY PGCINLSFAY 360
  361 VEGESLLMAL KDVALSSGSA CTSASLEPSY VLRAIGTDED LAHSSIRFGI GRFTTEEEVD 420
  421 YTVEKCIQHV KRLREMSPLW EMVQDGIDLK SIKWTQH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 95.522879
Match: 1p3wB
Description: Cysteine desulfurase IscS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 3.40354781002256 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 3.40354781002256 bayes_pls_golite062009
transferase activity 2.59075614411581 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 2.30133284041702 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
cysteine desulfurase activity 1.30923778688541 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
L-alanine:2-oxoglutarate aminotransferase activity 1.06988190956423 bayes_pls_golite062009
alanine-oxo-acid transaminase activity 1.06988190956423 bayes_pls_golite062009
transcription regulator activity 0.977210827616757 bayes_pls_golite062009
binding 0.942651665520336 bayes_pls_golite062009
ligase activity 0.827063849687833 bayes_pls_golite062009
DNA binding 0.803965264969424 bayes_pls_golite062009
nucleic acid binding 0.699955808682622 bayes_pls_golite062009
carbon-sulfur lyase activity 0.698312655247044 bayes_pls_golite062009
transcription factor activity 0.597417107954964 bayes_pls_golite062009
5-aminolevulinate synthase activity 0.54326874956263 bayes_pls_golite062009
cystathionine gamma-lyase activity 0.505859361763689 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.50269055590758 bayes_pls_golite062009
cystathionine beta-lyase activity 0.27933426619091 bayes_pls_golite062009
glycine hydroxymethyltransferase activity 0.271623203801431 bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity 0.234399054481664 bayes_pls_golite062009
RNA binding 0.222777224430863 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
methyltransferase activity 0.103986924428507 bayes_pls_golite062009
sulfurtransferase activity 0.0450490929307473 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.0254276656964899 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle