YRC Public Data Repository - Protein Structure Prediction

Protein:	YFCY_ECOLI, FADI...
Organism:	Escherichia coli
Length:	436 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFCY_ECOLI, FADI....

Description	E-value	Query Range	Subject Range
gi\|3309206 - gi\|3309206\|gb\|AAC26026.1\| thiolase B [Clostridium acetobutylicum] gi\|14994394, gi\|... - gi\|3309206\|gb\|AAC26026.1\| thiolase B [Clostridium acetobutylicum], gi\|15004782\|ref\|NP_149242.1\| acet...	378.0	[0..12]	[436..1]
gi\|115251727, gi... - gi\|126700290\|ref\|YP_001089187.1\| putative acetyl-CoA acetyltransferase [Clostridium difficile 630], ...	376.0	[0..12]	[435..1]
gi\|90573693, gi\|... - gi\|90573693\|ref\|ZP_01230204.1\| hypothetical protein CdifQ_02002956 [Clostridium difficile QCD-32g58]... gi\|255518068 - gi\|255518068\|ref\|ZP_05385744.1\| putative acetyl-CoA acetyltransferase [Clostridium difficile QCD-97b... gi\|255651184 - gi\|255651184\|ref\|ZP_05398086.1\| putative acetyl-CoA acetyltransferase [Clostridium difficile QCD-37x... gi\|254976268 - gi\|254976268\|ref\|ZP_05272740.1\| putative acetyl-CoA acetyltransferase [Clostridium difficile QCD-66c... gi\|255093654 - gi\|255093654\|ref\|ZP_05323132.1\| putative acetyl-CoA acetyltransferase [Clostridium difficile CIP 107... gi\|255315403 - gi\|255315403\|ref\|ZP_05356986.1\| putative acetyl-CoA acetyltransferase [Clostridium difficile QCD-76w...	375.0	[0..12]	[435..1]
gi\|28202508, gi\|... - gi\|28210073\|ref\|NP_781017.1\| acetyl-CoA acetyltransferase [Clostridium tetani E88], gi\|28202508\|gb\|A...	374.0	[0..12]	[435..1]
gi\|77996685, gi\|... - gi\|78044570\|ref\|YP_360188.1\| acetyl-CoA acetyltransferase [Carboxydothermus hydrogenoformans Z-2901]...	372.0	[0..12]	[434..1]
gi\|82725156, gi\|... - gi\|82747075\|ref\|ZP_00909576.1\| Thiolase [Clostridium beijerincki NCIMB 8052], gi\|82725156\|gb\|EAP5990...	370.0	[0..12]	[436..1]
gi\|13622708, gi\|... - gi\|15675510\|ref\|NP_269684.1\| putative acetyl-CoA:acetyltransferase [Streptococcus pyogenes M1 GAS], ... gi\|71853939, gi\|... - gi\|71911157\|ref\|YP_282707.1\| acetyl-CoA acetyltransferase [Streptococcus pyogenes MGAS5005], gi\|7185...	369.0	[0..12]	[433..1]
gi\|50914736, gi\|... - gi\|50914736\|ref\|YP_060708.1\| Acetyl-CoA acetyltransferase [Streptococcus pyogenes MGAS10394], gi\|509...	368.0	[0..12]	[433..1]
gi\|94544478, gi\|... - gi\|94990970\|ref\|YP_599070.1\| Acetyl-CoA acetyltransferase [Streptococcus pyogenes MGAS10270], gi\|945... gi\|71904047, gi\|... - gi\|71904047\|ref\|YP_280850.1\| acetyl-CoA acetyltransferase [Streptococcus pyogenes MGAS6180], gi\|7180...	367.0	[0..12]	[433..1]

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Predicted Domain #1

Region A:
Residues: [1-436]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQVLPLVTR QGDRIAIVSG LRTPFARQAT AFHGIPAVDL GKMVVGELLA RSEIPAEVIE  60
   61 QLVFGQVVQM PEAPNIAREI VLGTGMNVHT DAYSVSRACA TSFQAVANVA ESLMAGTIRA 120
  121 GIAGGADSSS VLPIGVSKKL ARVLVDVNKA RTMSQRLKLF SRLRLRDLMP VPPAVAEYST 180
  181 GLRMGDTAEQ MAKTYGITRE QQDALAHRSH QRAAQAWSDG KLKEEVMTAF IPPYKQPLVE 240
  241 DNNIRGNSSL ADYAKLRPAF DRKHGTVTAA NSTPLTDGAA AVILMTESRA KELGLVPLGY 300
  301 LRSYAFTAID VWQDMLLGPA WSTPLALERA GLTMSDLTLI DMHEAFAAQT LANIQLLGSE 360
  361 RFAREALGRA HATGEVDDSK FNVLGGSIAY GHPFAATGAR MITQTLHELR RRGGGFGLVT 420
  421 ACAAGGLGAA MVLEAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	93.154902
Match:	1ulqA
Description:	Crystal structure of tt0182 from Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetyl-CoA C-acyltransferase activity	8.08119341370748	bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity	7.45371477074071	bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity	5.63866392580915	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.96408928512745	bayes_pls_golite062009
fatty acid synthase activity	3.79121338118181	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] synthase activity	3.71249191203055	bayes_pls_golite062009
C-acyltransferase activity	3.27532895419051	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.14957464437124	bayes_pls_golite062009
acyltransferase activity	3.06879684191353	bayes_pls_golite062009
transferase activity	2.15834234036431	bayes_pls_golite062009
catalytic activity	2.14505178497871	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.87304265492939	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	1.77798276950874	bayes_pls_golite062009
acetyl-CoA C-acetyltransferase activity	1.50839304016514	bayes_pls_golite062009
C-acetyltransferase activity	1.19264084089277	bayes_pls_golite062009
hydroxymethylglutaryl-CoA synthase activity	1.16785899347652	bayes_pls_golite062009
acetyltransferase activity	0.6519546920419	bayes_pls_golite062009
binding	0.415385255550741	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.21899828831708	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: