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View Structure Prediction Details

Protein: Su(var)3-7-PA
Organism: Drosophila melanogaster
Length: 1250 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Su(var)3-7-PA.

Description E-value Query
Range
Subject
Range
gi|3970666 - gi|3970666|emb|CAA36434.1| suppressor of variegation protein 3-7 [Drosophila melanogaster]
799.0 [0..82] [1250..1]

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Predicted Domain #1
Region A:
Residues: [1-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRDSSMQAK NLDAQCNPDL KMASANSETL ASATHELKIM DVEGGALVDP DHIEEVETSM  60
   61 VIVVDDDDGD VAMVVEEDKH PMRDDPCIED IMDDEHAPLV AELQSALNNP DDKQASEDPL 120
  121 LEDQEREPDA MSTKTEPSSD AESSHSYHDP MGLLERIEIH DPGDSQDDDD EDDESSNGGG 180
  181 VDGGMRRKMP RAQRWLLWMK RWPWILHEDS DGTLAFCLYC NISINV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [227-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNRSRHIQQH NVSLSHQERE CNYLAFKKSE EETRGAISDN EIKHEFGTKS YVAAMKQKRI  60
   61 SETEAFNNFN WLRWLRWHPW LERSMPTGTI GTCRICSVRM NVEFVYLRKR HETTKGHMEA 120
  121 LRNLDSDKRS RKRKRSKSNS VTNSGGDEAE REKESEPEVG PEDAQDTPVV MMNGDVDSGD 180
  181 DPGKWCALIP DTNPQQCRCT LCNCTMAITS FLRHCKTRAH CHMLSTPAEK GSSDIRGIWA 240
  241 VFADMHPWLI ADPEDPSIGY CSVCRKRFMY GNSEIKRKNH EKSEKHTLAL ASAKAGIEVG 300
  301 SADGRGGDNM DEEEAAASDQ AQSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [551-776]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTDDSEDNDD DNWSEIQKLG KGFAHKSSSE PRKATVRAGV RFYPWLCYSK DRKTQICKFC  60
   61 RVRFHNEAAK ARHELSARHV KLVKQFKMRQ AKLHQGTNTQ TKHNAQDDEE SQEQDEEYGE 120
  121 EEEDAEEDSQ SNFDLGTVQA RKTARADNKL FVKPIPATMK GKVMVWKGRF PWLSYKKNEQ 180
  181 RGNYAWCKLC EVSLYLPSSK WASKHQRTSR HIRLRIDRKR NGGNPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.09691
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #4
Region A:
Residues: [777-930]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTSNKNSGEI STVVATASAL ASAEARQKAA MAELQAKYDW LDPDANDENH CHCRVCDSRL  60
   61 PIKVFYLRQH DASRKHVENK ERQRANAAAA ANAPSVSPTS TVDAERQESG MDKESENDMS 120
  121 VRSDGSTAEP LAKRSRRSME VRRIIRALRD SMGK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.11
Match: 1zr9A
Description: Solution Structure of a Human C2H2-type Zinc Finger Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.64382899824662 bayes_pls_golite062009
nucleic acid binding 1.34250831649865 bayes_pls_golite062009
DNA binding 1.19507161856307 bayes_pls_golite062009
transcription regulator activity 0.973915756412119 bayes_pls_golite062009
transcription factor activity 0.134824658171215 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [931-1017]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQEERSQMDM ARDMICSSFD IVTRLRTLER ESVAHNESMA QAPPSVTVSP IKPPEPRHVM  60
   61 DLFFDSISPT MKSLPPDLAA EGKSKIM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1018-1250]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLVCSLELRA MQRNATTPTP ATVSASSKWP SSTTVTPVKT PPAPISAPLA SVDADLHSSV  60
   61 VTTPHEYNNG QNNNNDKETV PKEPVTGASS AQVTINGSAK DLPENIRRIL TSNQTQVTNR 120
  121 LETDSVRCVP LDKLTTQSRT NVNGRLSQGG TSEAPSTPQA DLSNGNTLAM IRQIRVNNNN 180
  181 SSKITVTNTP QMQQPQQAQA SITSSTPIMR GGPSSNGCQI TTFRTMVNHN RRP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1wkrA
Description: Crystal structure of aspartic proteinase from Irpex lacteus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 0.885607925818602 bayes_pls_golite062009
catalytic activity 0.64464550126476 bayes_pls_golite062009
aspartic-type endopeptidase activity 0.560063975176208 bayes_pls_golite062009
aspartic-type peptidase activity 0.560063975176208 bayes_pls_golite062009
binding 0.176280665815209 bayes_pls_golite062009
peptidase activity 0.0546940803592719 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle