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View Structure Prediction Details

Protein: SOX9_PONPY
Organism: Pongo pygmaeus
Length: 509 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SOX9_PONPY.

Description E-value Query
Range
Subject
Range
gi|30583965, gi|... - gi|60653305|gb|AAX29347.1| SRY-box 9 [synthetic construct], gi|60653303|gb|AAX29346.1| SRY-box 9 [sy...
1.0E-64 [1..509] [1..509]
SOX9_CALJA - Transcription factor SOX-9 OS=Callithrix jacchus GN=SOX9 PE=2 SV=1
1.0E-64 [1..509] [1..509]
SOX9_PANTR - Transcription factor SOX-9 OS=Pan troglodytes GN=SOX9 PE=2 SV=1
2.0E-64 [1..509] [1..509]
gi|12698702 - gi|12698702|gb|AAK01648.1| SOX9 [Hylobates sp. TIB-201]
2.0E-64 [1..509] [1..509]
SOX9_PIG - Transcription factor SOX-9 OS=Sus scrofa GN=SOX9 PE=2 SV=1
5.0E-63 [1..509] [1..509]
SOX9_CANLF - Transcription factor SOX-9 OS=Canis lupus familiaris GN=SOX9 PE=2 SV=1
6.0E-63 [1..509] [1..513]
gi|60360276 - gi|60360276|dbj|BAD90382.1| mKIAA4243 protein [Mus musculus]
8.0E-63 [1..509] [59..565]
gi|109492166 - gi|109492166|ref|XP_001081628.1| PREDICTED: similar to Transcription factor SOX-9 [Rattus norvegicus...
2.0E-62 [1..509] [164..670]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLLDPFMKM TDEQEKGLSG APSPTMSEDS AGSPCPSGSG SDTENTRPQE NTFPKGEPDL  60
   61 KKESEEDKFP VCIREAVSQV LKGYDWTLVP MPVRVNGSSK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [101-260]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKPHVKRPMN AFMVWAQAAR RKLADQYPHL HNAELSKTLG KLWRLLNESE KRPFVEEAER  60
   61 LRVQHKKDHP DYKYQPRRRK SVKNGQAEAE EATEQTHISP NAIFKALQAD SPHSSSGMSE 120
  121 VHSPGEHSGQ SQGPPTPPTT PKTDVQPGKA DLKREGRPLP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 2gzkA
Description: No description for 2gzkA was found.

Predicted functions:

Term Confidence Notes
DNA binding 5.15324651287773 bayes_pls_golite062009
nucleic acid binding 5.01228762819617 bayes_pls_golite062009
transcription regulator activity 4.9607192917135 bayes_pls_golite062009
sequence-specific DNA binding 4.06355503548774 bayes_pls_golite062009
transcription factor activity 3.82658263870186 bayes_pls_golite062009
binding 3.6211482127468 bayes_pls_golite062009
transcription repressor activity 3.17018042329608 bayes_pls_golite062009
transcription activator activity 2.95665802871704 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.75319687398598 bayes_pls_golite062009
protein binding 2.18211240370246 bayes_pls_golite062009
chromatin binding 1.64428658020027 bayes_pls_golite062009
transcription factor binding 1.10315330167937 bayes_pls_golite062009
DNA bending activity 0.87985209274756 bayes_pls_golite062009
specific transcriptional repressor activity 0.4255419067266 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.261169200304829 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [261-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGGRQPPIDF RDVDIGELSS DVISNIETFD VNEFDQYLPP NGHPGVPATH GQVTYTGSYG  60
   61 ISSTAATPAS AGHVWMSKQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [340-509]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAPPPPPQQP PQAPPAPQAP PQPQAAPPQQ PAAPPQQPQA HTLTTLSSEP GQSQRTHIKT  60
   61 EQLSPSHYSE QQQHSPQQIA YSPFNLPHYS PSYPPITRSQ YDYTDHQNSS SYYSHAAGQG 120
  121 TGLYSTFTYM NPAQRPMYTP IADTSGVPSI PQTHSPQHWE QPVYTQLTRP 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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