YRC Public Data Repository - Protein Structure Prediction

Protein:	NFRB_ECOLI
Organism:	Escherichia coli
Length:	745 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NFRB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|190907454, gi... - gi\|75240726\|ref\|ZP_00724633.1\| COG1215: Glycosyltransferases, probably involved in cell wall biogene... gi\|110342391, gi... - gi\|110640799\|ref\|YP_668527.1\| bacteriophage N4 adsorption protein B [Escherichia coli 536], gi\|11034... gi\|227838539, gi... - gi\|227884453\|ref\|ZP_04002258.1\| bacteriophage N4 adsorption protein B [Escherichia coli 83972], gi\|2...	387.0	[0..1]	[745..1]
gi\|218557509, gi... - gi\|218557509\|ref\|YP_002390422.1\| bacteriophage N4 adsorption protein B [Escherichia coli S88], gi\|21... gi\|226898671, gi... - gi\|237707461\|ref\|ZP_04537942.1\| bacteriophage N4 receptor [Escherichia sp. 3_2_53FAA], gi\|226898671\|... gi\|115511916, gi... - gi\|117622792\|ref\|YP_851705.1\| bacteriophage N4 adsorption protein B [Escherichia coli APEC O1], gi\|1... gi\|91071188, gi\|... - gi\|91209614\|ref\|YP_539600.1\| bacteriophage N4 adsorption protein B [Escherichia coli UTI89], gi\|9107...	386.0	[0..1]	[745..1]
gi\|24111906, gi\|... - gi\|24111906\|ref\|NP_706416.1\| bacteriophage N4 adsorption protein B [Shigella flexneri 2a str. 301], ...	384.0	[0..1]	[745..1]
gi\|75210807, gi\|... - gi\|75210807\|ref\|ZP_00710939.1\| COG1215: Glycosyltransferases, probably involved in cell wall biogene...	381.0	[0..1]	[745..1]
gi\|170021080, gi... - gi\|170021080\|ref\|YP_001726034.1\| bacteriophage N4 adsorption protein B [Escherichia coli ATCC 8739],... gi\|188488536, gi... - gi\|75514657\|ref\|ZP_00736912.1\| COG1215: Glycosyltransferases, probably involved in cell wall biogene...	381.0	[0..1]	[745..1]
gi\|26106946, gi\|... - gi\|26246547\|ref\|NP_752586.1\| bacteriophage N4 adsorption protein B [Escherichia coli CFT073], gi\|261...	365.0	[0..26]	[745..1]
gi\|110804548, gi... - gi\|110804548\|ref\|YP_688068.1\| bacteriophage N4 adsorption protein B [Shigella flexneri 5 str. 8401],...	361.0	[0..26]	[745..1]
gi\|190900322, gi... - gi\|75226898\|ref\|ZP_00713788.1\| COG1215: Glycosyltransferases, probably involved in cell wall biogene...	359.0	[0..26]	[745..1]
gi\|75258699 - gi\|75258699\|ref\|ZP_00730106.1\| COG1215: Glycosyltransferases, probably involved in cell wall biogene...	343.0	[0..1]	[702..1]
gi\|90440894, gi\|... - gi\|90577808\|ref\|ZP_01233619.1\| bacteriophage N4 receptor, subunit, inner membrane protein [Vibrio an...	313.0	[0..4]	[725..3]

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Predicted Domain #1

Region A:
Residues: [1-374]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDWLLDVFAT WLYGLKVIAI TLAVIMFISG LDDFFIDVVY WVRRIKRKLS VYRRYPRMSY  60
   61 RELYKPDEKP LAIMVPAWNE TGVIGNMAEL AATTLDYENY HIFVGTYPND PDTQRDVDEV 120
  121 CARFPNVHKV VCARPGPTSK ADCLNNVLDA ITQFERSANF AFAGFILHDA EDVISPMELR 180
  181 LFNYLVERKD LIQIPVYPFE REWTHFTSMT YIDEFSELHG KDVPVREALA GQVPSAGVGT 240
  241 CFSRRAVTAL LADGDGIAFD VQSLTEDYDI GFRLKEKGMT EIFVRFPVVD EAKEREQRKF 300
  301 LQHARTSNMI CVREYFPDTF STAVRQKSRW IIGIVFQGFK THKWTSSLTL NYFLWRDRKG 360
  361 AISNFVSFLA MLVM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.0
Match:	2d7iA
Description:	No description for 2d7iA was found.

Predicted Domain #2

Region A:
Residues: [375-499]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQLLLLLAYE SLWPDAWHFL SIFSGSAWLM TLLWLNFGLM VNRIVQRVIF VTGYYGLTQG  60
   61 LLSVLRLFWG NLINFMANWR ALKQVLQHGD PRRVAWDKTT HDFPSVTGDT RSLRPLGQIL 120
  121 LENQV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [500-624]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITEEQLDTAL RNRVEGLRLG GSMLMQGLIS AEQLAQALAE QNGVAWESID AWQIPSSLIA  60
   61 EMPASVALHY AVLPLRLEND ELIVGSEDGI DPVSLAALTR KVGRKVRYVI VLRGQIVTGL 120
  121 RHWYA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.69897
Match:	2d28C
Description:	Structure of the N-terminal domain of XpsE (crystal form P43212)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [625-745]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRRGHDPRAM LYNAVQHQWL TEQQAGEIWR QYVPHQFLFA EILTTLGHIN RSAINVLLLR  60
   61 HERSSLPLGK FLVTEGVISQ ETLDRVLTIQ RELQVSMQSL LLKAGLNTEQ VAQLESENEG 120
  121 E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.69897
Match:	1p9rA
Description:	Crystal Structure of Vibrio cholerae putative NTPase EpsE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleoside-triphosphatase activity	0.877006883015441	bayes_pls_golite062009
pyrophosphatase activity	0.844507013828883	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.834454826299636	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.831965349922447	bayes_pls_golite062009
binding	0.626981987734364	bayes_pls_golite062009
transporter activity	0.48424022775161	bayes_pls_golite062009
transmembrane transporter activity	0.43068338046008	bayes_pls_golite062009
hydrolase activity	0.35546973066672	bayes_pls_golite062009
ATPase activity	0.329342647154672	bayes_pls_golite062009
catalytic activity	0.234613562021476	bayes_pls_golite062009
ATPase activity, coupled	0.176394296840172	bayes_pls_golite062009
active transmembrane transporter activity	0.0712149467387941	bayes_pls_golite062009
primary active transmembrane transporter activity	0.0075971145531164	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.0031784073031893	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: