YRC Public Data Repository - Protein Structure Prediction

Protein:	MFD_ECOLI
Organism:	Escherichia coli
Length:	1148 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MFD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|90109238, gi\|... - gi\|90109238\|pdb\|2EYQ\|B Chain B, Crystal Structure Of Escherichia Coli Transcription-Repair Coupling ...	992.0	[0..1]	[1148..4]
gi\|110342882, gi... - gi\|110641290\|ref\|YP_669020.1\| transcription-repair coupling factor [Escherichia coli 536], gi\|110342...	991.0	[0..1]	[1148..17]
gi\|83569563 - gi\|83569563\|ref\|ZP_00921015.1\| COG1197: Transcription-repair coupling factor (superfamily II helicas...	991.0	[0..1]	[1148..17]
gi\|157160641, gi... - gi\|75195297\|ref\|ZP_00705367.1\| COG1197: Transcription-repair coupling factor (superfamily II helicas...	990.0	[0..1]	[1148..1]
gi\|188491808, gi... - gi\|75511397\|ref\|ZP_00734080.1\| COG1197: Transcription-repair coupling factor (superfamily II helicas...	989.0	[0..1]	[1148..1]
gi\|30040893, gi\|... - gi\|30062647\|ref\|NP_836818.1\| transcription-repair coupling factor [Shigella flexneri 2a str. 2457T],...	989.0	[0..1]	[1148..1]
gi\|74311675, gi\|... - gi\|74311675\|ref\|YP_310094.1\| transcription-repair coupling factor [Shigella sonnei Ss046], gi\|738551...	989.0	[0..1]	[1148..1]
gi\|189370352, gi... - gi\|189370352\|gb\|EDU88768.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. EC86... gi\|168783484, gi... - gi\|188999153\|gb\|EDU68139.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. EC40... gi\|195938873 - gi\|195938873\|ref\|ZP_03084255.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. ... gi\|189375509, gi... - gi\|189375509\|gb\|EDU93925.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. EC50... gi\|168757829, gi... - gi\|189355265\|gb\|EDU73684.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. EC44... gi\|168751336, gi... - gi\|188014612\|gb\|EDU52734.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. EC41... gi\|168771340, gi... - gi\|189359855\|gb\|EDU78274.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. EC44... gi\|15830746, gi\|... - gi\|15830746\|ref\|NP_309519.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. Sak... gi\|189365183, gi... - gi\|189365183\|gb\|EDU83599.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. EC45... gi\|217328545, gi... - gi\|217328545\|ref\|ZP_03444627.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. ... gi\|209773000, gi... - pir\|\|D90815 transcription-repair coupling factor [imported] - Escherichia coli (strain O157:H7, subs... gi\|15830746, gi\|... - gi\|15830746\|ref\|NP_309519.1\| transcription-repair coupling factor [Escherichia coli O157:H7], gi\|133... gi\|254591897, gi... - gi\|254792497\|ref\|YP_003077334.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str.... gi\|208815000, gi... - gi\|208815000\|ref\|ZP_03256179.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. ... gi\|208809609, gi... - gi\|208809609\|ref\|ZP_03251946.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. ... gi\|209399391, gi... - gi\|209399391\|ref\|YP_002269959.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str.... gi\|208737970, gi... - gi\|208822485\|ref\|ZP_03262804.1\| transcription-repair coupling factor [Escherichia coli O157:H7 str. ...	989.0	[0..1]	[1148..1]
gi\|75239611, gi\|... - gi\|75239611\|ref\|ZP_00723578.1\| COG1197: Transcription-repair coupling factor (superfamily II helicas...	989.0	[0..1]	[1148..1]

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Predicted Domain #1

Region A:
Residues: [1-1148]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEQYRYTLP VKAGEQRLLG ELTGAACATL VAEIAERHAG PVVLIAPDMQ NALRLHDEIS  60
   61 QFTDQMVMNL ADWETLPYDS FSPHQDIISS RLSTLYQLPT MQRGVLIVPV NTLMQRVCPH 120
  121 SFLHGHALVM KKGQRLSRDA LRTQLDSAGY RHVDQVMEHG EYATRGALLD LFPMGSELPY 180
  181 RLDFFDDEID SLRVFDVDSQ RTLEEVEAIN LLPAHEFPTD KAAIELFRSQ WRDTFEVKRD 240
  241 PEHIYQQVSK GTLPAGIEYW QPLFFSEPLP PLFSYFPANT LLVNTGDLET SAERFQADTL 300
  301 ARFENRGVDP MRPLLPPQSL WLRVDELFSE LKNWPRVQLK TEHLPTKAAN ANLGFQKLPD 360
  361 LAVQAQQKAP LDALRKFLET FDGPVVFSVE SEGRREALGE LLARIKIAPQ RIMRLDEASD 420
  421 RGRYLMIGAA EHGFVDTVRN LALICESDLL GERVARRRQD SRRTINPDTL IRNLAELHIG 480
  481 QPVVHLEHGV GRYAGMTTLE AGGITGEYLM LTYANDAKLY VPVSSLHLIS RYAGGAEENA 540
  541 PLHKLGGDAW SRARQKAAEK VRDVAAELLD IYAQRAAKEG FAFKHDREQY QLFCDSFPFE 600
  601 TTPDQAQAIN AVLSDMCQPL AMDRLVCGDV GFGKTEVAMR AAFLAVDNHK QVAVLVPTTL 660
  661 LAQQHYDNFR DRFANWPVRI EMISRFRSAK EQTQILAEVA EGKIDILIGT HKLLQSDVKF 720
  721 KDLGLLIVDE EHRFGVRHKE RIKAMRANVD ILTLTATPIP RTLNMAMSGM RDLSIIATPP 780
  781 ARRLAVKTFV REYDSMVVRE AILREILRGG QVYYLYNDVE NIQKAAERLA ELVPEARIAI 840
  841 GHGQMREREL ERVMNDFHHQ RFNVLVCTTI IETGIDIPTA NTIIIERADH FGLAQLHQLR 900
  901 GRVGRSHHQA YAWLLTPHPK AMTTDAQKRL EAIASLEDLG AGFALATHDL EIRGAGELLG 960
  961 EEQSGSMETI GFSLYMELLE NAVDALKAGR EPSLEDLTSQ QTEVELRMPS LLPDDFIPDV1020
 1021 NTRLSFYKRI ASAKTENELE EIKVELIDRF GLLPDPARTL LDIARLRQQA QKLGIRKLEG1080
 1081 NEKGGVIEFA EKNHVNPAWL IGLLQKQPQH YRLDGPTRLK FIQDLSERKT RIEWVRQFMR1140
 1141 ELEENAIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	2eyqA
Description:	Crystal structure of Escherichia coli transcription-repair coupling factor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.37148167194523	bayes_pls_golite062009
hydrolase activity	1.18412998130788	bayes_pls_golite062009
pyrophosphatase activity	1.16998111465319	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.16375481834344	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.15942143195918	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.15882580213621	bayes_pls_golite062009
binding	0.712909626033412	bayes_pls_golite062009
ATPase activity	0.62253664120117	bayes_pls_golite062009
helicase activity	0.00674361801283974	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: