YRC Public Data Repository - Protein Structure Prediction

Protein:	GSPC_ECOLI
Organism:	Escherichia coli
Length:	271 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GSPC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|67939397, gi\|... - gi\|67939397\|ref\|ZP_00531900.1\| Peptidase S1, chymotrypsin:PDZ/DHR/GLGF [Chlorobium phaeobacteroides ...	188.0	[0..1]	[271..173]
gi\|21674268, gi\|... - gi\|21674268\|ref\|NP_662333.1\| serine protease [Chlorobium tepidum TLS], gi\|21647438\|gb\|AAM72675.1\| se...	180.0	[0..1]	[271..175]
gi\|194334370, gi... - gi\|68553592\|ref\|ZP_00592962.1\| Peptidase S1, chymotrypsin:PDZ/DHR/GLGF [Prosthecochloris aestuarii D...	180.0	[0..1]	[261..172]
gi\|46400566, gi\|... - gi\|46446925\|ref\|YP_008290.1\| putative serine proteinase [Candidatus Protochlamydia amoebophila UWE25...	178.0	[0..1]	[269..163]
gi\|94418130 - gi\|94418130\|ref\|ZP_01297946.1\| hypothetical protein PaerP_01000281 [Pseudomonas aeruginosa PA7]	177.0	[0..2]	[265..136]
gi\|78224552, gi\|... - gi\|78224552\|ref\|YP_386299.1\| peptidase S1C, Do [Geobacter metallireducens GS-15], gi\|78195807\|gb\|ABB...	177.0	[0..1]	[270..141]
gi\|1184684, gi\|1... - gi\|157004259\|gb\|ABV00672.1\| MucD [Pseudomonas aeruginosa], gi\|1220194\|gb\|AAC43718.1\| MucD, gi\|118468... gi\|9946654, gi\|1... - gi\|9946654\|gb\|AAG04155.1\|AE004511_8 serine protease MucD precursor [Pseudomonas aeruginosa PAO1], gi... gi\|254245021, gi... - gi\|254245021\|ref\|ZP_04938343.1\| serine protease MucD precursor [Pseudomonas aeruginosa 2192], gi\|194...	176.0	[0..2]	[265..146]
gi\|40063421 - gi\|40063421\|gb\|AAR38232.1\| MucD protein [uncultured marine bacterium 580]	176.0	[0..2]	[270..140]
gi\|91201112 - gi\|91201112\|emb\|CAJ74171.1\| similar to heat shock protease DegP/HtrA [Candidatus Kuenenia stuttgarti...	175.0	[0..1]	[262..182]
gi\|12963467 - gi\|12963467\|gb\|AAK11276.1\|AF343973_1 MucD [Pseudomonas aeruginosa] gi\|115583903, gi... - gi\|116048682\|ref\|YP_792518.1\| serine protease MucD precursor [Pseudomonas aeruginosa UCBPP-PA14], gi...	175.0	[0..2]	[265..146]

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Predicted Domain #1

Region A:
Residues: [1-271]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTLRFPFHL ANHNKDAAIN ILIIFISIGS IIFNVNYFHT TIVKNGQIIN QPTNAFQSDF  60
   61 SLAALWRNEN HAGVKDANPV AVNQETPKLS IALNGIVLTS NDETSFVLIN EGSEQKRYSL 120
  121 NEALESAPGT FIRKINKTSV VFETHGHYEK VTLHPGLPDI IKQPDSESQN VLADYIIATP 180
  181 IRDGEQIYGL RLNPRKGLNA FTTSLLQPGD IALRINNLSL THPDEVSQAL SLLLTQQSAQ 240
  241 FTIRRNGVPR LINVSVGELT GMNGLRHERT Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.522879
Match:	1ky9A
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	0.81546887337164	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.5672666868164	bayes_pls_golite062009
binding	0.566291652083235	bayes_pls_golite062009
protein binding	0.52823753548825	bayes_pls_golite062009
serine hydrolase activity	0.50826037975448	bayes_pls_golite062009
serine-type peptidase activity	0.508252655710209	bayes_pls_golite062009
endopeptidase activity	0.264500844139819	bayes_pls_golite062009
serine-type endopeptidase activity	0.201782736081951	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: