YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|151941818
Organism:	Saccharomyces cerevisiae YJM789
Length:	377 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|151941818.

Description	E-value	Query Range	Subject Range
PPH22 - Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated a... PP2A2_YEAST - Serine/threonine-protein phosphatase PP2A-2 catalytic subunit OS=Saccharomyces cerevisiae (strain AT... gi\|190405183 - gi\|190405183\|gb\|EDV08450.1\| protein phosphatase type 2A [Saccharomyces cerevisiae RM11-1a] gi\|151941818 - gi\|151941818\|gb\|EDN60174.1\| protein phosphatase type 2A [Saccharomyces cerevisiae YJM789]	0.0	[1..377]	[1..377]
PP2AB_RABIT - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Oryctolagus cuniculus GN=P...	0.0	[71..377]	[3..309]
PP2AA_CHICK - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Gallus gallus GN=PPP2CA P...	0.0	[76..377]	[8..309]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[71..377]	[3..309]
gi\|57097893 - gi\|57097893\|ref\|XP_539988.1\| PREDICTED: similar to Serine/threonine protein phosphatase 2A, catalyti... gi\|109086079, gi... - gi\|109086083\|ref\|XP_001084684.1\| PREDICTED: similar to Serine/threonine-protein phosphatase 2A catal... PP2AB_RAT - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2c... PP2AB_MOUSE - Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Mus musculus GN=Ppp2cb PE=... gi\|56821 - gi\|56821\|emb\|CAA34167.1\| unnamed protein product [Rattus rattus] gi\|53733970 - gb\|AAH84043.1\| Unknown (protein for MGC:98396) [Xenopus laevis] gi\|114619603 - gi\|114619603\|ref\|XP_519697.2\| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes] gi\|194226459 - gi\|194226459\|ref\|XP_001493923.2\| PREDICTED: protein phosphatase 2 (formerly 2A), catalytic subunit, ... ENSCJAT00000024203 - null PPP2CB - protein phosphatase 2, catalytic subunit, beta isozyme	0.0	[71..377]	[3..309]
gi\|119390121 - gi\|119390121\|pdb\|2IE3\|C Chain C, Structure Of The Protein Phosphatase 2a Core Enzyme Bound To Tumor-... PP2AA_RAT - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Rattus norvegicus GN=Ppp2... PP2AA_MOUSE - Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Mus musculus GN=Ppp2ca PE... gi\|56819 - gi\|56819\|emb\|CAA34166.1\| unnamed protein product [Rattus rattus]	0.0	[76..377]	[8..309]

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Predicted Domain #1

Region A:
Residues: [1-377]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMEIDDPMH GSDEDQLSPT LDEDMNSDDG KNNTKARSND EDTDEELEDF NFKPGSSGIA  60
   61 DHKSSKPLKL TNTNINQLDQ WIEHLSKCEP LSEDDVARLC KMAVDVLQFE ENVKPINVPV 120
  121 TICGDVHGQF HDLLELFKIG GPCPDTNYLF MGDYVDRGYY SVETVSYLVA MKVRYPHRIT 180
  181 ILRGNHESRQ ITQVYGFYDE CLRKYGSANV WKMFTDLFDY FPVTALVDNK IFCLHGGLSP 240
  241 MIETIDQVRD LNRIQEVPHE GPMCDLLWSD PDDRGGWGIS PRGAGFTFGQ DISEQFNHTN 300
  301 DLSLIARAHQ LVMEGYSWSH QQNVVTIFSA PNYCYRCGNQ AAIMEVDENH NRQFLQYDPS 360
  361 VRPGEPTVTR KTPDYFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	912.0
Match:	1it6A_
Description:	Protein phosphatase-1 (PP-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	6.04386346716682	bayes_pls_golite062009
myosin phosphatase activity	5.31703100176823	bayes_pls_golite062009
hydrolase activity	3.13006743434485	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68552051869632	bayes_pls_golite062009
kinase activity	1.67788383575784	bayes_pls_golite062009
structural molecule activity	1.5850868178597	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57807175808088	bayes_pls_golite062009
protein kinase activity	1.4514460578232	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
transferase activity	1.3407391509244	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
molecular transducer activity	1.08090214431427	bayes_pls_golite062009
signal transducer activity	1.08090214431427	bayes_pls_golite062009
calmodulin binding	0.77173071932406	bayes_pls_golite062009
protein serine/threonine kinase activity	0.66803085638835	bayes_pls_golite062009
substrate-specific transporter activity	0.528189469950839	bayes_pls_golite062009
structural constituent of muscle	0.126411744957937	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: