YRC Public Data Repository - Protein Structure Prediction

Protein:	END1_ECOLI
Organism:	Escherichia coli
Length:	235 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for END1_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|82394536 - gi\|82394536\|gb\|ABB72357.1\| endonuclease I precursor [Vibrio diabolicus]	363.0	[0..1]	[232..1]
gi\|91073901, gi\|... - gi\|91212327\|ref\|YP_542313.1\| endonuclease I precursor [Escherichia coli UTI89], gi\|91073901\|gb\|ABE08... gi\|237706402, gi... - gi\|237706402\|ref\|ZP_04536883.1\| endonuclease I [Escherichia sp. 3_2_53FAA], gi\|226899442\|gb\|EEH85701...	362.0	[0..1]	[235..2]
gi\|218559936, gi... - gi\|218559936\|ref\|YP_002392849.1\| DNA-specific endonuclease I [Escherichia coli S88], gi\|218366705\|em... gi\|115514296, gi... - gi\|117625172\|ref\|YP_854160.1\| DNA-specific endonuclease I [Escherichia coli APEC O1], gi\|115514296\|g... gi\|227834769, gi... - gi\|227888500\|ref\|ZP_04006305.1\| deoxyribonuclease I [Escherichia coli 83972], gi\|227834769\|gb\|EEJ452...	362.0	[0..1]	[235..1]
gi\|26249366, gi\|... - gi\|26249366\|ref\|NP_755406.1\| endonuclease I precursor [Escherichia coli CFT073], gi\|26109774\|gb\|AAN8...	361.0	[0..1]	[235..2]
gi\|116184480, gi... - gi\|75855130\|ref\|ZP_00762791.1\| COG2356: Endonuclease I [Vibrio sp. Ex25], gi\|254230222\|ref\|ZP_049236...	360.0	[0..1]	[232..1]
NUCM_DICD3 - Nuclease nucM OS=Dickeya dadantii (strain 3937) GN=nucM PE=2 SV=1 NUCM_ERWCH - (P37994) Nuclease nucM precursor (EC 3.1.21.-)	359.0	[0..1]	[235..1]
gi\|110344686, gi... - gi\|110643094\|ref\|YP_670824.1\| endonuclease I precursor [Escherichia coli 536], gi\|110344686\|gb\|ABG70... gi\|191171804, gi... - gi\|75241259\|ref\|ZP_00725121.1\| COG2356: Endonuclease I [Escherichia coli F11], gi\|191171804\|ref\|ZP_0...	359.0	[0..1]	[235..1]
gi\|226839618, gi... - gi\|254037994\|ref\|ZP_04872052.1\| DNA-specific endonuclease I [Escherichia sp. 1_1_43], gi\|226839618\|g... gi\|56480217, gi\|... - gi\|56480217\|ref\|NP_708710.2\| DNA-specific endonuclease I [Shigella flexneri 2a str. 301], gi\|5638376... gi\|110616401, gi... - gi\|110806853\|ref\|YP_690373.1\| DNA-specific endonuclease I [Shigella flexneri 5 str. 8401], gi\|110616...	358.0	[0..1]	[235..1]
gi\|208734863, gi... - gi\|208813586\|ref\|ZP_03254915.1\| endonuclease I [Escherichia coli O157:H7 str. EC4045], gi\|208734863\|... gi\|208807077, gi... - gi\|208807077\|ref\|ZP_03249414.1\| endonuclease I [Escherichia coli O157:H7 str. EC4206], gi\|208726878\|... gi\|195937083 - gi\|195937083\|ref\|ZP_03082465.1\| DNA-specific endonuclease I [Escherichia coli O157:H7 str. EC4024] gi\|168797520, gi... - gi\|189379784\|gb\|EDU98200.1\| endonuclease I [Escherichia coli O157:H7 str. EC508], gi\|168797520\|ref\|Z... gi\|217327025, gi... - gi\|217327025\|ref\|ZP_03443108.1\| endonuclease I [Escherichia coli O157:H7 str. TW14588], gi\|217319392... gi\|209396449, gi... - gi\|209396449\|ref\|YP_002272425.1\| endonuclease I [Escherichia coli O157:H7 str. EC4115], gi\|209157849... gi\|208739468, gi... - gi\|208819345\|ref\|ZP_03259665.1\| endonuclease I [Escherichia coli O157:H7 str. EC4042], gi\|208739468\|... gi\|189369337, gi... - gi\|189369337\|gb\|EDU87753.1\| endonuclease I [Escherichia coli O157:H7 str. EC4501], gi\|168760087\|ref\|... gi\|168753897, gi... - gi\|189358537\|gb\|EDU76956.1\| endonuclease I [Escherichia coli O157:H7 str. EC4401], gi\|168753897\|ref\|... gi\|188017864, gi... - gi\|188017864\|gb\|EDU55986.1\| endonuclease I [Escherichia coli O157:H7 str. EC4113], gi\|168747563\|ref\|... gi\|189373972, gi... - gi\|189373972\|gb\|EDU92388.1\| endonuclease I [Escherichia coli O157:H7 str. EC869], gi\|168785803\|ref\|Z... gi\|168781804, gi... - gi\|189000582\|gb\|EDU69568.1\| endonuclease I [Escherichia coli O157:H7 str. EC4076], gi\|168781804\|ref\|... gi\|187770991, gi... - gi\|187770991\|gb\|EDU34835.1\| endonuclease I [Escherichia coli O157:H7 str. EC4196], gi\|168773416\|ref\|... gi\|168766952, gi... - gi\|189363671\|gb\|EDU82090.1\| endonuclease I [Escherichia coli O157:H7 str. EC4486], gi\|168766952\|ref\|... gi\|13363293, gi\|... - gi\|15833075\|ref\|NP_311848.1\| DNA-specific endonuclease I [Escherichia coli O157:H7], gi\|13363293\|dbj... gi\|13363293, gi\|... - gi\|15833075\|ref\|NP_311848.1\| DNA-specific endonuclease I [Escherichia coli O157:H7 str. Sakai], gi\|1... gi\|209760108, gi... - pir\|\|E91106 DNA-specific endonuclease I [imported] - Escherichia coli (strain O157:H7, substrain RI... gi\|254594297, gi... - gi\|254794897\|ref\|YP_003079734.1\| DNase I [Escherichia coli O157:H7 str. TW14359], gi\|254594297\|gb\|AC...	358.0	[0..1]	[235..1]
gi\|25350700 - pir\|\|H85951 DNA-specific endonuclease I [imported] - Escherichia coli (strain O157:H7, substrain ED... gi\|15803484, gi\|... - gi\|15803484\|ref\|NP_289517.1\| DNA-specific endonuclease I [Escherichia coli O157:H7 EDL933], gi\|12517...	358.0	[0..1]	[235..1]

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Predicted Domain #1

Region A:
Residues: [1-235]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRYLSIAAV VLSAAFSGPA LAEGINSFSQ AKAAAVKVHA DAPGTFYCGC KINWQGKKGV  60
   61 VDLQSCGYQV RKNENRASRV EWEHVVPAWQ FGHQRQCWQD GGRKNCAKDP VYRKMESDMH 120
  121 NLQPSVGEVN GDRGNFMYSQ WNGGEGQYGQ CAMKVDFKEK AAEPPARARG AIARTYFYMR 180
  181 DQYNLTLSRQ QTQLFNAWNK MYPVTDWECE RDERIAKVQG NHNPYVQRAC QARKS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.0
Match:	1ouoA
Description:	Crystal structure of the periplasmic endonuclease Vvn
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
deoxyribonuclease I activity	6.32878221233886	bayes_pls_golite062009
hydrolase activity	3.83116222475834	bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters	3.37342567983553	bayes_pls_golite062009
deoxyribonuclease activity	2.76079360787098	bayes_pls_golite062009
endonuclease activity	2.16521397757363	bayes_pls_golite062009
endodeoxyribonuclease activity	1.9890436405178	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.81997094124327	bayes_pls_golite062009
nuclease activity	1.41172530475566	bayes_pls_golite062009
catalytic activity	1.0342182748198	bayes_pls_golite062009
binding	0.663236820712292	bayes_pls_golite062009
caspase-activated deoxyribonuclease activity	0.571337616862676	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: