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View Structure Prediction Details

Protein: CE36953
Organism: Caenorhabditis elegans
Length: 626 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE36953.

Description E-value Query
Range
Subject
Range
gi|47229253 - gi|47229253|emb|CAG04005.1| unnamed protein product [Tetraodon nigroviridis]
328.0 [0..5] [393..1]

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Predicted Domain #1
Region A:
Residues: [1-462]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFVMWMWLF VVWITVLFGV SNGGILDRSC GRRRVGYITS WGKHPFRDDQ AEKLTHLVFA  60
   61 FFVVDSDGSV KLEGDAAKAR LEHVKEVASR HPDLKLLYAV GGWENSQYFS VLTADHSRRS 120
  121 ILISNFVKVI KEYGFDGVDI DWEYPVTGGA VEGTPADRRN YVNLMRELRN ELRDLESETG 180
  181 KSYLISFAGA AGHWVLKPGY DLQQLMKYCD FVNVMSYDYF GAWASKWGAY TGPPAPLQFA 240
  241 MPKKFSGRMN VHATMKDYSC QIKATDKINM GVPFYGRFWK NVGDAVDSTD DMWRTATATN 300
  301 SEGTKFEGGD VQWRDLHEKF DTTKTKFHSG SKTPFIWLSE QKTFVGYENA ESLKHKVDYI 360
  361 VENNIGGVMI WAIDFDDDQG TLLNSAAAES ICTTSTKSFN YKCSPVDDKR WWTYDDNEEL 420
  421 AGMCGKSSPL IDGYYPVCDP DDPGHACCGK YGYCGSGAEF CS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 1wawA
Description: Specificity and affnity of natural product cyclopentapeptide inhibitor Argadin against human chitinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
chitinase activity 6.40555694403866 bayes_pls_golite062009
imaginal disc growth factor activity 3.9608908661313 bayes_pls_golite062009
growth factor activity 2.18932950777991 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 1.91170236789651 bayes_pls_golite062009
receptor binding 1.89435893935497 bayes_pls_golite062009
amylase activity 1.38959979746158 bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds 1.34796838721403 bayes_pls_golite062009
chitin binding 1.29046765706168 bayes_pls_golite062009
binding 1.1885466730171 bayes_pls_golite062009
carbohydrate binding 0.80333288291596 bayes_pls_golite062009
glucosidase activity 0.766503513427695 bayes_pls_golite062009
protein binding 0.690517649847952 bayes_pls_golite062009
catalytic activity 0.534516847146079 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 0.266938437560648 bayes_pls_golite062009
hexosaminidase activity 0.21148675734804 bayes_pls_golite062009
hydrolase activity 0.178746202646272 bayes_pls_golite062009
pattern binding 0.113396113487931 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [463-626]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPECIDYGAD PNLILKEPVK PSQKITWYTS DAGEGKRGRC GRDVPPLEGE APTCNPDDAN  60
   61 AHCCSNGGYC GNSKEHCECN GCIDFAKQRD FKYKPLEWWT FSENPANVGR CGYNAPRLST 120
  121 GKIPKCDPDS ESYCCSNSGY CGKGEQYCSC LGCADFKANP AFEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.30103
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.70076684537777 bayes_pls_golite062009
growth factor activity 2.98754787930869 bayes_pls_golite062009
binding 2.11319437256866 bayes_pls_golite062009
protein binding 1.99839937208979 bayes_pls_golite062009
glycosaminoglycan binding 1.69932456942774 bayes_pls_golite062009
heparin binding 1.31822233987881 bayes_pls_golite062009
epidermal growth factor receptor binding 1.28588198220215 bayes_pls_golite062009
pattern binding 1.26957983931218 bayes_pls_golite062009
polysaccharide binding 1.11978732751628 bayes_pls_golite062009
carbohydrate binding 0.72748768329894 bayes_pls_golite062009
extracellular matrix structural constituent 0.6530199085873 bayes_pls_golite062009
transcription factor binding 0.25674871945811 bayes_pls_golite062009
transcription regulator activity 0.217489473629515 bayes_pls_golite062009
transcription cofactor activity 0.18562100414853 bayes_pls_golite062009
ErbB-2 class receptor binding 0.0190385772244036 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle