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View Structure Prediction Details

Protein: him-8
Organism: Caenorhabditis elegans
Length: 361 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for him-8.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
417.0 [0..44] [360..2515]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGNSLNSFV NIRIYGKTLE NLKHYGLIEY LNEFAGGSSF VSLTESTSIS SINTATVDTP  60
   61 RFSTPIVPNV GL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQKFTLNLSE KISEIGPNDE NEDLKESYDQ EPEEELNSSH ESNNSVEKVM DMIIEDVVSN  60
   61 HTTNIADGDD INSPIVSSGQ SEFLQDGVDN DGNIDDYEEY QSLPPNDDVI MNETELMDVD 120
  121 RTTVMTPLRS PTFFDYHNES GDEDQLNENE MKSPDSKNDE INKDEIHNIQ CHFPNCNRAI 180
  181 AWKRKYGKLR LIDHALVHCD KNFLKCK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.154902
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [280-361]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KCKHTCHTIR QMRYHYRIFH STSKMEGFGV SGLPTKNKGF QKIMNACFAD QLVEMNKRKN  60
   61 PPKSQNGSRR SRVKSKSKRS GI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.33104470146352 bayes_pls_golite062009
DNA binding 0.750106478442632 bayes_pls_golite062009
nucleic acid binding 0.393163105327437 bayes_pls_golite062009
protein binding 0.309302474986083 bayes_pls_golite062009
transcription regulator activity 0.130445238810851 bayes_pls_golite062009
transcription factor activity 9.32354595580165E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle