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View Structure Prediction Details

Protein: him-8
Organism: Caenorhabditis elegans
Length: 361 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for him-8.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
417.0 [0..44] [360..2515]

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Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGNSLNSFV NIRIYGKTLE NLKHYGLIEY LNEFAGGSSF VSLTESTSIS SINTATVDTP  60
   61 RFSTPIVPNV GL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQKFTLNLSE KISEIGPNDE NEDLKESYDQ EPEEELNSSH ESNNSVEKVM DMIIEDVVSN  60
   61 HTTNIADGDD INSPIVSSGQ SEFLQDGVDN DGNIDDYEEY QSLPPNDDVI MNETELMDVD 120
  121 RTTVMTPLRS PTFFDYHNES GDEDQLNENE MKSPDSKNDE INKDEIHNIQ CHFPNCNRAI 180
  181 AWKRKYGKLR LIDHALVHCD KNFLKCK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.154902
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [280-361]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KCKHTCHTIR QMRYHYRIFH STSKMEGFGV SGLPTKNKGF QKIMNACFAD QLVEMNKRKN  60
   61 PPKSQNGSRR SRVKSKSKRS GI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.33104470146352 bayes_pls_golite062009
DNA binding 0.750106478442632 bayes_pls_golite062009
nucleic acid binding 0.393163105327437 bayes_pls_golite062009
protein binding 0.309302474986083 bayes_pls_golite062009
transcription regulator activity 0.130445238810851 bayes_pls_golite062009
transcription factor activity 9.32354595580165E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle