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View Structure Prediction Details

Protein: NIA2_ARATH
Organism: Arabidopsis thaliana
Length: 917 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NIA2_ARATH.

Description E-value Query
Range		 Subject
Range
gi|110742690 - gi|110742690|dbj|BAE99256.1| nitrate reductase [Arabidopsis thaliana]
 1085.0 [0..1] [917..1]

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Predicted Domain #1
Region A:
Residues: [1-76] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAASVDNRQY ARLEPGLNGV VRSYKPPVPG RSDSPKAHQN QTTNQTVFLK PAKVHDDDED  60
   61 VSSEDENETH NSNAVY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-537] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKEMIRKSNA ELEPSVLDPR DEYTADSWIE RNPSMVRLTG KHPFNSEAPL NRLMHHGFIT  60
   61 PVPLHYVRNH GHVPKAQWAE WTVEVTGFVK RPMKFTMDQL VSEFAYREFA ATLVCAGNRR 120
  121 KEQNMVKKSK GFNWGSAGVS TSVWRGVPLC DVLRRCGIFS RKGGALNVCF EGSEDLPGGA 180
  181 GTAGSKYGTS IKKEYAMDPS RDIILAYMQN GEYLTPDHGF PVRIIIPGFI GGRMVKWLKR 240
  241 IIVTTKESDN FYHFKDNRVL PSLVDAELAD EEGWWYKPEY IINELNINSV ITTPCHEEIL 300
  301 PINAFTTQRP YTLKGYAYSG GGKKVTRVEV TVDGGETWNV CALDHQEKPN KYGKFWCWCF 360
  361 WSLEVEVLDL LSAKEIAVRA WDETLNTQPE KMIWNLMGMM NNCWFRVKTN VCKPHKGEIG 420
  421 IVFEHPTLPG NESGGWMAKE RHLEKSADAP PSLKKSVSTP F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 136.0
Match: 2bihA
Description: crystal structure of the Molybdenum-containing nitrate reducing fragment of Pichia angusta assimilatory nitrate reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [538-657] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTTAKMYSM SEVKKHNSAD SCWIIVHGHI YDCTRFLMDH PGGSDSILIN AGTDCTEEFE  60
   61 AIHSDKAKKM LEDYRIGELI TTGYSSDSSS PNNSVHGSSA VFSLLAPIGE ATPVRNLALV 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.522879
Match: 1do9A
Description: Cytochrome b5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1.94941127592758 bayes_pls_golite062009
cytochrome-c oxidase activity 1.91951393988999 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 1.91951393988999 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors 1.91951393988999 bayes_pls_golite062009
sterol desaturase activity 1.72061589886774 bayes_pls_golite062009
C-5 sterol desaturase activity 1.72061589886774 bayes_pls_golite062009
linoleoyl-CoA desaturase activity 1.72061589886774 bayes_pls_golite062009
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity 1.68214478072718 bayes_pls_golite062009
heme-copper terminal oxidase activity 1.67979832413891 bayes_pls_golite062009
binding 1.56870596629206 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 1.05227276400356 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.888859895539844 bayes_pls_golite062009
oxidoreductase activity 0.850524633890514 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.842413203688846 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.808453086600089 bayes_pls_golite062009
cation transmembrane transporter activity 0.602390039366203 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.493634303942328 bayes_pls_golite062009
protein binding 0.268795825133297 bayes_pls_golite062009
steroid binding 0.177535173083536 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [658-917] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPRAKVPVQL VEKTSISHDV RKFRFALPVE DMVLGLPVGK HIFLCATIND KLCLRAYTPS  60
   61 STVDVVGYFE LVVKIYFGGV HPRFPNGGLM SQYLDSLPIG STLEIKGPLG HVEYLGKGSF 120
  121 TVHGKPKFAD KLAMLAGGTG ITPVYQIIQA ILKDPEDETE MYVIYANRTE EDILLREELD 180
  181 GWAEQYPDRL KVWYVVESAK EGWAYSTGFI SEAIMREHIP DGLDGSALAM ACGPPPMIQF 240
  241 AVQPNLEKMQ YNIKEDFLIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.39794
Match: 1cnfA
Description: STRUCTURAL STUDIES ON CORN NITRATE REDUCTASE: REFINED STRUCTURE OF THE CYTOCHROME B REDUCTASE FRAGMENT AT 2.5 ANGSTROMS, ITS ADP COMPLEX AND AN ACTIVE SITE MUTANT AND MODELING OF THE CYTOCHROME B DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on NADH or NADPH 4.30648542212464 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 4.04090398393497 bayes_pls_golite062009
coenzyme binding 3.33805077160148 bayes_pls_golite062009
NADH dehydrogenase activity 3.28962873390534 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 3.20430149465423 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor 3.111558299994 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 3.03192933933799 bayes_pls_golite062009
oxidoreductase activity 3.02740987944465 bayes_pls_golite062009
FAD binding 2.07600122867642 bayes_pls_golite062009
cytochrome-b5 reductase activity 1.5685421124725 bayes_pls_golite062009
binding 1.56341797572673 bayes_pls_golite062009
ferredoxin-NADP+ reductase activity 1.46342400843015 bayes_pls_golite062009
ferredoxin reductase activity 1.46342400843015 bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor 1.46342400843015 bayes_pls_golite062009
catalytic activity 1.45374095556065 bayes_pls_golite062009
sulfite reductase (NADPH) activity 1.43049542627708 bayes_pls_golite062009
NADP or NADPH binding 1.18833847639357 bayes_pls_golite062009
demethylase activity 1.1768217851058 bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors 0.73475657802914 bayes_pls_golite062009
transferase activity 0.708491789248912 bayes_pls_golite062009
FMN binding 0.649158247260553 bayes_pls_golite062009
riboflavin synthase activity 0.380537461428523 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 0.33163571415742 bayes_pls_golite062009
cofactor binding 0.205324283520452 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 0.11268023449343 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle