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View Structure Prediction Details

Protein: cyh-1
Organism: Caenorhabditis elegans
Length: 332 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cyh-1.

Description E-value Query
Range
Subject
Range
gi|114599953 - gi|114599953|ref|XP_517728.2| PREDICTED: cyclin B1 [Pan troglodytes]
249.0 [0..15] [308..266]

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Predicted Domain #1
Region A:
Residues: [1-332]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYATSTQKRE WTYTPEKLAA MRLEINIKFR QKYESVMQPD ELELFVTPEE ELRMQRSIED  60
   61 AALKFADKFR PHIWPSVKWT ALAFFKRAFL VWVPSDTSIR MVMMACFYLA MKIDEFYITI 120
  121 EDFVKNMNVG EPRQNAERIL KLEPELMKIL DYNLTVHCPY RPYEGHLMDM KTRMLLLNFD 180
  181 LESIRRDSMR FFQNALQTDV LLLYPPSQIA LAAINFGLHA QGKSDEILRE FLRKLIGIEE 240
  241 DSWAHRDARP EDLEKLEKTV TRVNQIMREV DRNFVAVTEQ ERENHKSQLA RIQALIPALD 300
  301 ERRKEQWLAG GGVGLMPGEL AEQPVDSDDE IN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.522879
Match: 1kxuA
Description: CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 8.12427628405368 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
binding 2.22200513900429 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00665312545368 bayes_pls_golite062009
DNA binding 1.6980508926231 bayes_pls_golite062009
nucleic acid binding 1.63159454080484 bayes_pls_golite062009
protein kinase regulator activity 1.57249948737107 bayes_pls_golite062009
kinase regulator activity 1.52575847462915 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 1.46764878302741 bayes_pls_golite062009
protein binding 1.37124095423514 bayes_pls_golite062009
transcription factor activity 1.0145450763465 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
enzyme regulator activity 0.614716645534491 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.36347576272001 bayes_pls_golite062009
transcription coactivator activity 0.138191616709499 bayes_pls_golite062009
transcription activator activity 0.0696060248241566 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle