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View Structure Prediction Details

Protein: aqp-8
Organism: Caenorhabditis elegans
Length: 294 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for aqp-8.

Description E-value Query
Range
Subject
Range
gi|73971745 - gi|73971745|ref|XP_854596.1| PREDICTED: similar to Aquaporin 3 [Canis familiaris]
233.0 [0..1] [289..1]

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Predicted Domain #1
Region A:
Residues: [1-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVFQDKVAS ILRIEDQQFT RELLAECIGT FFLLLIGNAA NIQAAVAVGG NSTSCHIAWG  60
   61 IGFMFAVYLA ASVSGGHLNP AISVAQSILG NLPPWKIIPY AIAQVIGAFL GAAVAYFGHH 120
  121 DDLWKLDGGI RQVTGGQATA GLFTTFPPDH MSVWGSLLDQ IIGTAMLSGL VCLITDKRHQ 180
  181 IPTGVVPVLA GSIMSMVAMT FGANGGFAIN PARDFGPRVF CLCAGYGWEV FSAHGYYFWI 240
  241 PIVGALIGSI IGAWIYKIFV GLHGMNESLD IQPAKGFNVS VKVDREYSDS SGSY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.522879
Match: 1fx8A
Description: Glycerol uptake facilitator protein GlpF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
water transmembrane transporter activity 10.3414560257964 bayes_pls_golite062009
water channel activity 10.2169080705067 bayes_pls_golite062009
amide transmembrane transporter activity 8.22334514934522 bayes_pls_golite062009
urea channel activity 8.22334514934522 bayes_pls_golite062009
urea transmembrane transporter activity 8.22334514934522 bayes_pls_golite062009
glycerol transmembrane transporter activity 6.84984722645819 bayes_pls_golite062009
alcohol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
polyol transmembrane transporter activity 6.65010837320829 bayes_pls_golite062009
transporter activity 5.23077472964938 bayes_pls_golite062009
pyrimidine transmembrane transporter activity 5.22583580934587 bayes_pls_golite062009
substrate-specific channel activity 5.0695479460357 bayes_pls_golite062009
substrate-specific transporter activity 5.06520190871345 bayes_pls_golite062009
channel activity 5.06054430984045 bayes_pls_golite062009
passive transmembrane transporter activity 5.06054430984045 bayes_pls_golite062009
transmembrane transporter activity 4.83314424546299 bayes_pls_golite062009
glycerol channel activity 4.65460547189577 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.82456291801633 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity 1.9587945604969 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.57078059027065 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 1.57017437613762 bayes_pls_golite062009
nucleobase transmembrane transporter activity 1.34339324336864 bayes_pls_golite062009
purine transmembrane transporter activity 1.34339324336864 bayes_pls_golite062009
binding 1.29002883661034 bayes_pls_golite062009
amine transmembrane transporter activity 1.16825682067665 bayes_pls_golite062009
ion transmembrane transporter activity 0.516648340085278 bayes_pls_golite062009
active transmembrane transporter activity 0.315342449421593 bayes_pls_golite062009
protein binding 0.279304481542405 bayes_pls_golite062009
structural molecule activity 0.180281371901848 bayes_pls_golite062009
cation transmembrane transporter activity 0.141210715822635 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0368961725897963 bayes_pls_golite062009

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